%A Farida, Yunahara %A Rahmat, Deni %A Amanda, Agi Widia %D 2018 %T Anti-Inflammation Activity Test of Nanoparticles Ethanol Extract of Temulawak Rhizome (Curcuma xanthorrhiza Roxb.) with Protein Denaturation Inhibition Method %K %X Javanese turmeric rhizome (Curcuma xanthorrhiza Roxb.) has been known to have many health benefits as antibacterial, anti-inflammatory, antidiabetic and anticancer. The purpose of this study was to compare the anti-inflammatory activity of temulawak rhizome extract with its nanoparticles. Temulawak rhizome extract was obatained by maceration using 96% (v/v) ethanol as a solvent. The extracts were made into nanoparticles by ionic gelation method which used chitosan and tripolyphosphate. The results of antiinflammatory activity test using a method of inhibiting protein denaturation showed the persentage of inhibition of protein denaturation (IC 50 ) of the extract of temulawak rhizome of 521.67±5.80 ppm while the IC 50 of the nanoparticles was 398.02±1.78 ppm. Accordingly, the antiinflammatory activity of the nanoparticles was better than the extract of temulawak rhizome. %U http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/569 %J JURNAL ILMU KEFARMASIAN INDONESIA %0 Journal Article %R 10.35814/jifi.v16i2.569 %P 225-230%V 16 %N 2 %@ 2614-6495 %8 2018-10-30