TY - JOUR AU - Dwi Sandhiutami, Ni Made AU - Desmiaty, Yesi AU - Darmastuti, Nattika Sari AU - Muhammad, Fahri PY - 2020 TI - Anti–Platelet Aggregation and Anti-Inflamatory Eff ect from Ethanol Extract Of Tembelekan Leaves (Lantana Camara Linn.) In Vivo JF - JURNAL ILMU KEFARMASIAN INDONESIA; Vol 18 No 2 (2020): JIFI DO - 10.35814/jifi.v18i2.707 KW - N2 - Atherosclerosis is chronic inflammatory disease that can be prevented with anti-inflammatory activity agents and reduce thrombus formation in blood vessels. Tembelekan leaves (Lantana camara Linn.) contain fl avonoids, saponins, and essential oils which potential to inhibit platelet aggregation and be anti-inflammatory. This study aimed to test the in vivo anti-platelet aggregation and anti-inflammatory activity of tembelekan leaves. Platelet anti-aggregation test was carried out on mice by assessing the decrease in plasma absorbance after addition of ADP. Mice were divided into normal group, positive control group which was given clopidogrel and 3 test groups which were given Tembelekan leaf extract at a dose of 2.5, 5, 10 g/kgBW. In vivo anti-inflammatory test used the Winter method with intraplantar 1% carrageenan as inducer. There was a signifi cant decrease in plasma absorbance after addition of ADP at doses of 2.5 and 5 g/kgBW of tembelekan leaves i.e 5.47% and 12.28% compared to the normal group. Positive control and dose of 10 g/kgBW gave the same eff ect. In anti-inflammatory test, the doses of 3.2 and 6.4 g/kgBW of tembelekan leaves gave percentage value of inhibition which was not signifi cantly diff erent with diclofenac sodium. Tembelekan leaves potentially as anti-platelet aggregation and anti-inflammatory properties. UR - http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/707