@article{JIFI, author = {Silvi Nurafni and Tri Desminingrum and Evida Mainanda}, title = { Comparison of Side Effects Propofol-Fentanyl and Propofol-Fentanyl-Midazolam in Central Medical Installation Hospital X Bogor}, journal = {JURNAL ILMU KEFARMASIAN INDONESIA}, volume = {20}, number = {1}, year = {2022}, keywords = {}, abstract = {Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The effective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability significant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side effects propofol-fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted  in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17,2±3 mmHg, diastolic blood pressure 5,3±1,6 mmHg, pulse 3,9±1,5 beats/minute, and RR 1,4±0,01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11,8±0,4 mmHg, diastolic blood preasure 4,2±0,4 mmHg, pulse value 5,0±0,9 beats/minute, and RR 2,8±0,9 breaths/minute. Side effects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not significantly different.}, issn = {2614-6495}, pages = {1--5}, doi = {10.35814/jifi.v20i1.817}, url = {http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/817} }