@article{JIFI,
	author = {Silvi Nurafni and Tri Desminingrum and Evida Mainanda},
	title = { Comparison of Side Effects Propofol-Fentanyl and  Propofol-Fentanyl-Midazolam in Central Medical  Installation Hospital X Bogor},
	journal = {JURNAL ILMU KEFARMASIAN INDONESIA},
	volume = {20},
	number = {1},
	year = {2022},
	keywords = {},
	abstract = {Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The effective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability significant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side effects propofol-fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conductedÂ  in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17,2Â±3 mmHg, diastolic blood pressure 5,3Â±1,6 mmHg, pulse 3,9Â±1,5 beats/minute, and RR 1,4Â±0,01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11,8Â±0,4 mmHg, diastolic blood preasure 4,2Â±0,4 mmHg, pulse value 5,0Â±0,9 beats/minute, and RR 2,8Â±0,9 breaths/minute. Side effects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not significantly different.},
	issn = {2614-6495},	pages = {1--5},	doi = {10.35814/jifi.v20i1.817},
	url = {http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/817}
}