TY - JOUR AU - Dwitiyanti, Dwitiyanti AU - Hayati, Hayati AU - Anggraeni, Sindi PY - 2021/04/19 TI - Ethanol Extract Activity Test of 70% Calliandra calothyrsus Meisn. Leaves as a Lowering of Blood Glucose Levels in Hyperglycemic Rats JF - JURNAL ILMU KEFARMASIAN INDONESIA; Vol 19 No 1 (2021): JIFIDO - 10.35814/jifi.v19i1.916 KW - N2 - Diabetes mellitus (DM) is an increase in blood glucose levels due to impaired metabolism of carbohydrates, fats, and proteins. Red kaliandra leaf ( Calliandra calothyrsus Meisn.) contains tocopherol, carotenoid, flavonoid, saponin, and tannin compounds are natural sources of non-enzymatic antioxidants. The active compound has inhibitory activity against the α-glucosidase enzyme so that it can be potential as an antidiabetic. This study aims to determine the activity of 70% ethanol extract of red calliandra leaves on the decrease in blood glucose levels in male white rats Sprague Dawley hyperglycemia strain. Test animals were divided into 6 groups consisting of normal controls (standard feed), negative controls (alloxan induction), positive controls (metformin HCL dose 51.38 mg/kg), group I dose (50 mg/kg), dose II (100 mg/kg), and dose III (200 mg/kg). Data were analyzed using one way ANOVA and continued by Tukey test. The results showed that doses 1, 2, and 3 can reduce blood glucose. Dose 3 had a decrease in the percentage of 58.08% which was comparable to a positive control (metformin HCl dose 51.38 mg/kg) of 63.85%. UR - http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/916