Formulation of facial liquid soap wıth 4-(Dimethylamino) chalcone and virgin coconut oil as antibacterial agents against acne-causing bacteria

  • Putri Wulandari Masters of Pharmaceutical Science, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Esti Mumpuni Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Esti Mulatsari Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Kartiningsih Kartiningsih Departement of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
DOI: https://doi.org/10.35814/jifi.v23i2.1653

Abstract

Acne vulgaris is a multifactorial skin disorder commonly associated with infections caused by Staphylococcus epidermidis and Cutibacterium acnes. This study aimed to develop and evaluate an antibacterial facial liquid soap containing 4-(Dimethylamino) chalcone and virgin coconut oil (VCO). The synthesized chalcone, a flavonoid derivative obtained through the Claisen–Schmidt condensation reaction, was characterized using TLC, melting point analysis, UV-Vis spectrophotometry, and LC-MS/MS. Formulations containing 1.25% and 2.5% chalcone combined with 40% VCO were prepared and tested. Antibacterial activity was evaluated using the agar diffusion method, while physical properties were assessed through organoleptic observation, homogeneity, foaming ability, pH measurement, stability testing, and skin irritation tests. The 1.25% chalcone formulation demonstrated strong antibacterial activity, producing inhibition zones of 19.40±0.39 mm against C. acnes and 18.97±0.45 mm against S. epidermidis. All formulations were stable, homogeneous, and non-irritating. These findings indicate a synergistic antibacterial effect between chalcone and VCO, supporting their potential use as natural active ingredients in anti-acne facial soap formulations.

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Published
2025-11-19
How to Cite
WULANDARI, Putri et al. Formulation of facial liquid soap wıth 4-(Dimethylamino) chalcone and virgin coconut oil as antibacterial agents against acne-causing bacteria. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 23, n. 2, p. 390-397, nov. 2025. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1653>. Date accessed: 09 dec. 2025. doi: https://doi.org/10.35814/jifi.v23i2.1653.
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Vol 23 No 2 (2025): JIFI
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