Sintesis dan Uji Antioksidan Senyawa 1,5-bis(3’-etoksi-4’-hidroksifenil)-1,4-pentadien-3-on (EHP)

  • ESTI MUMPUNI UNIVERSITAS PANCASILA
  • ENJANG RUSNAWAN UNIVERSITAS PANCASILA
  • EVI SULASTRI UNIVERSITAS PANCASILA
  • INDRIANA PERMATASARI UNIVERSITAS PANCASILA

Abstrak

Telah dilakukan sintesis senyawa1,5-bis(3’-etoksi-4’-hidroksifenil)-1,4-pentadien-3-on (EHP)


dengan metode kondensasi aldol, dengan etil vanilin dan aseton sebagai bahan baku, serta asam klorida


sebagai katalisator. Identitikasi senyawa EHP dilakukan melalui interpretasi data gabungan dari KLT,


UV-Vis, FT-IR, KG-SM dan RMI, Aktivitas antioksidan EHP (IC50 8.66 µg/mL) lebih baik dibanding


kurkumin (IC50 11.44 µg/mL), ditunjukkan dengan metode DPPH .

Referensi

1. Sardjiman. Synthesis of Some New Series of Curcumin Analogues, Antioxydative Activity and Structure Activity Relationship [Dissertation], Gadjah Mada University, Yogyakarta; 2000.

2. Youssef, K.M, et aI.,Synthesis and Antitumor Activity of Some Curcumin Analogs. Department of Pharmaceutical Chemistry College of Pharmaceutical, King Saudi University,Riyadh, Saudi Arabia Arch Pharm Chem Life Sci. 2005. 338:181-9.

3. Ohori, H. et al., Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for thc medicinal treatment of cancer [abstract], Mol Cancer Ther, 2006. 5(10): 2563-71.

4. Supardjan AM dan Permatasari I. Sintesis Senyawa Bahan Alam 1,5 bis(4’-hidr0ksi-3’metoksifeni1)- 1,4-pentadien-3-on. Majalah Obat Tradisional. Vol ll April-Jimi. 2006. (36): 15-20.

5. Sardjiman SS, Samhoedi M, Hakim L, Vandergoot, H, Timmerman H. Syntheis and Structure Activity Relationship 1,5-diphenyl-1.4-pentadien-3-ones-and Cycle Analogues an Antioxidative Agent. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia. 2000. 175-84.

6. Simanjuntak P. Radikal Bebas dan Antioksidan. Majalah Natural. 2006. (17): 14-6,

7. Rao MNA. Antioxidant Properties of Curcumin. Departement of Pharmaceutical Chemistry College of Pharmaceutical Science. Manipal, India. 1997. 39-42,

8. Penzlin G, Furhop J. Organic Synthesis, Concept, Methods, Starting and Material. In: Dr. Gerd Giesler, editor, Fedral Republik of Germany. 1986. 1-58,
Diterbitkan
2010-09-30
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MUMPUNI, ESTI et al. Sintesis dan Uji Antioksidan Senyawa 1,5-bis(3’-etoksi-4’-hidroksifenil)-1,4-pentadien-3-on (EHP). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 2, p. 91-100, sep. 2010. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/336>. Tanggal Akses: 16 aug. 2025
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