Synthesis and Antioxidant Test of 1,5-bis(3’-etoksi-4’- hidroksifenil)-1,4-pentadien-3-on (EHP) Compound

  • ESTI MUMPUNI UNIVERSITAS PANCASILA
  • ENJANG RUSNAWAN UNIVERSITAS PANCASILA
  • EVI SULASTRI UNIVERSITAS PANCASILA
  • INDRIANA PERMATASARI UNIVERSITAS PANCASILA

Abstract

Synthesis of 1,5-bis(3’-etoxy-4’-hydroxyphenyI)-1,4-pentadiene-3-on (EHP) by aldol


condensation method from ethyl Vanilin and acetone, using hydrochloride acid as a catalyst, has been


conducted. Identification of the EHP compound was done through interpretation of UV-Vis, FT-IR,


GC-MS and NMR data, The antioxidant activity of EHP (IC50 8.66 µg/mL) is higher than curcumin (IC50


11.44 µg/mL) as demonstrated by the DPPH method.

References

1. Sardjiman. Synthesis of Some New Series of Curcumin Analogues, Antioxydative Activity and Structure Activity Relationship [Dissertation], Gadjah Mada University, Yogyakarta; 2000.

2. Youssef, K.M, et aI.,Synthesis and Antitumor Activity of Some Curcumin Analogs. Department of Pharmaceutical Chemistry College of Pharmaceutical, King Saudi University,Riyadh, Saudi Arabia Arch Pharm Chem Life Sci. 2005. 338:181-9.

3. Ohori, H. et al., Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for thc medicinal treatment of cancer [abstract], Mol Cancer Ther, 2006. 5(10): 2563-71.

4. Supardjan AM dan Permatasari I. Sintesis Senyawa Bahan Alam 1,5 bis(4’-hidr0ksi-3’metoksifeni1)- 1,4-pentadien-3-on. Majalah Obat Tradisional. Vol ll April-Jimi. 2006. (36): 15-20.

5. Sardjiman SS, Samhoedi M, Hakim L, Vandergoot, H, Timmerman H. Syntheis and Structure Activity Relationship 1,5-diphenyl-1.4-pentadien-3-ones-and Cycle Analogues an Antioxidative Agent. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia. 2000. 175-84.

6. Simanjuntak P. Radikal Bebas dan Antioksidan. Majalah Natural. 2006. (17): 14-6,

7. Rao MNA. Antioxidant Properties of Curcumin. Departement of Pharmaceutical Chemistry College of Pharmaceutical Science. Manipal, India. 1997. 39-42,

8. Penzlin G, Furhop J. Organic Synthesis, Concept, Methods, Starting and Material. In: Dr. Gerd Giesler, editor, Fedral Republik of Germany. 1986. 1-58,
Published
2010-09-30
How to Cite
MUMPUNI, ESTI et al. Synthesis and Antioxidant Test of 1,5-bis(3’-etoksi-4’- hidroksifenil)-1,4-pentadien-3-on (EHP) Compound. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 2, p. 91-100, sep. 2010. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/336>. Date accessed: 01 apr. 2025.
Citation Formats
Issue
Vol 8 No 2 (2010): JIFI
Section
Articles
License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.