Synthesis and Antioxidant Test of 1,5-bis(3’-etoksi-4’- hidroksifenil)-1,4-pentadien-3-on (EHP) Compound

  • ESTI MUMPUNI UNIVERSITAS PANCASILA
  • ENJANG RUSNAWAN UNIVERSITAS PANCASILA
  • EVI SULASTRI UNIVERSITAS PANCASILA
  • INDRIANA PERMATASARI UNIVERSITAS PANCASILA

Abstract

Synthesis of 1,5-bis(3’-etoxy-4’-hydroxyphenyI)-1,4-pentadiene-3-on (EHP) by aldol


condensation method from ethyl Vanilin and acetone, using hydrochloride acid as a catalyst, has been


conducted. Identification of the EHP compound was done through interpretation of UV-Vis, FT-IR,


GC-MS and NMR data, The antioxidant activity of EHP (IC50 8.66 µg/mL) is higher than curcumin (IC50


11.44 µg/mL) as demonstrated by the DPPH method.

References

1. Sardjiman. Synthesis of Some New Series of Curcumin Analogues, Antioxydative Activity and Structure Activity Relationship [Dissertation], Gadjah Mada University, Yogyakarta; 2000.

2. Youssef, K.M, et aI.,Synthesis and Antitumor Activity of Some Curcumin Analogs. Department of Pharmaceutical Chemistry College of Pharmaceutical, King Saudi University,Riyadh, Saudi Arabia Arch Pharm Chem Life Sci. 2005. 338:181-9.

3. Ohori, H. et al., Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for thc medicinal treatment of cancer [abstract], Mol Cancer Ther, 2006. 5(10): 2563-71.

4. Supardjan AM dan Permatasari I. Sintesis Senyawa Bahan Alam 1,5 bis(4’-hidr0ksi-3’metoksifeni1)- 1,4-pentadien-3-on. Majalah Obat Tradisional. Vol ll April-Jimi. 2006. (36): 15-20.

5. Sardjiman SS, Samhoedi M, Hakim L, Vandergoot, H, Timmerman H. Syntheis and Structure Activity Relationship 1,5-diphenyl-1.4-pentadien-3-ones-and Cycle Analogues an Antioxidative Agent. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia. 2000. 175-84.

6. Simanjuntak P. Radikal Bebas dan Antioksidan. Majalah Natural. 2006. (17): 14-6,

7. Rao MNA. Antioxidant Properties of Curcumin. Departement of Pharmaceutical Chemistry College of Pharmaceutical Science. Manipal, India. 1997. 39-42,

8. Penzlin G, Furhop J. Organic Synthesis, Concept, Methods, Starting and Material. In: Dr. Gerd Giesler, editor, Fedral Republik of Germany. 1986. 1-58,
Published
2010-09-30
How to Cite
MUMPUNI, ESTI et al. Synthesis and Antioxidant Test of 1,5-bis(3’-etoksi-4’- hidroksifenil)-1,4-pentadien-3-on (EHP) Compound. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 2, p. 91-100, sep. 2010. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/336>. Date accessed: 23 apr. 2024.
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