Influence Administration of Penicillin Prophylactic Antibiotics with Cephalosporins towards The Clinical Signs of Superficial IDO and LOS to SC Patients in Hospital "X"

  • Teulis Sumiartini Universitas Pancasila
  • Dian Ratih Laksmitawati Fakultas Farmasi, Universitas Pancasila
  • Hesti Utami Ramadaniati Fakultas Farmasi, Universitas Pancasila
  • Ranald Irwanto Fakultas Farmasi, Universitas Pancasila

Abstract

A hospital "X" in Jakarta has priority obstetrics services with a high birth rate. Sectio caesarea (SC) at the hospital uses prophylactic antibiotics penicillin and cephalosporins to reducing superficial Surgical Site Infection (IDO). Complication of infection can increase prolongs stay patient (length of stay - LOS). The aim of this study is to look the influence administration of penicillin prophylactic antibiotics with cephalosporins towards the clinical signs of superficial IDO and LOS to SC patients in hospital "X". The test sample calculated using a formula of two proportions difference with retrospective data tracing from medical records which are analyzed using the Chi-Square method with the help of Microsoft Excel to determine the influence administration of penicillin prophylactic antibiotics with cephalosporins towards the clinical signs of superficial IDO and LOS. The results showed that the chi-square calculated value in bivariate analysis of prophylactic antibiotics with LOS and clinical signs of IDO are smaller than the Chi-Square table value (Chi-Square table value at degree of freedom (DF) 1 and significance of 0.05 = 3.8415) with a p value greater than 0.05. In conclusion, there is no statistically significant difference in influence between the group receiving penicillin prophylactic antibiotics with the group receiving cephalosporin prophylactic antibiotics towards the clinical signs of superficial IDO and LOS to SC patients in hospital "X".

References

1. Cunningham.2013. Obstetri Williams. Jakarta: EGC. Hal 774-797

2. RS "X". Panduan Penggunaan Antibiotik. 2nd ed. Jakarta: RS "X". 2017

3. Kemenkes Kesehatan Republik Indonesia. Capaian Pembangunan Kesehatan. 2010. Jakarta:Kemenkes

4. Scottish Intercollegiate Guidelines Network. Antibiotic prophilaxis in surgery: A national clinical guideline. 2008

5. Hopkins L, Smaill FM. Antibiotic prophylaxis regimens and drugs for cesarean section (Review). Cochrane Database of Systematic Reviews. 2010

6. Dahlan S. Statistik untuk Kedokteran dan Kesehatan. 6th ed. 2014. Jakarta: Sagung Seto

7. Maryunani, Anik. Asuhan Kegawatdaruratan Maternal & Neonatal. 2013. Jakarta: Trans Info Medika

8. Quinn JA, Munoz FM, Gonik B, Frau L, Cutland C, et al. Preterm birth: Case defi nition & guidelines for data collection, analysis, and presentation of immunisation safety data. 2016.0264-410X/©2016 Published by Elsevier Ltd.

9. Blumenfeld YJ, et al. Risk Factors for Prolonged Postpartum Length of Stay Following Caesarean Delivery. July 2015. California

10. Rubin, RH. Surgical wound infection: epidemiology, pathogenesis, diagnosis and management. 2006. BMC Infectious Disease.

11. Centers for Disease Control and Prevention. Guideline for Prevention of Surgical Site Infection [Internet]. 2017 [cited 2021 Mar 12]. Available from: Surgical Site Infection | Guidelines | Infection Control | CDC.

12. Dewi, Vivian N.L., Sunarsih, Tri. Asuhan Kebidanan pada Ibu Nifas. 2013. Jakarta: Salemba Medika.

13. World Health Organization. WHO recommendations for prevention and treatment of maternal peripartum infections. 2015.

14. Hidayat A. Tutorial cara uji chi square dengan excel. [Internet]. 2012 [cited 2021 Mar 12]. Available from: Tutorial Cara Uji Chi Square Dengan Excel - Uji Statistik (statistikian.com)

15. Hidayat A. Tabel chi square atau chi square table dalam excel. [Internet]. 2012 [cited 2021
Mar 12]. Available from: Tabel Chi Square Atau Chi Square Table Dalam Excel - Uji Statistik
(statistikian.com).

16. Ahmed ETS, Mirghani OA, Gerais AS, Adam I. Ceftriaxone versus ampicillin/ cloxacillin as antibiotic
prophylaxis in elective caesarean section. Sudan: Eastern Mediterranean Health Journal, Vol. 10, No. 3. 2004.

17. Ziogos E, Tsiodras S, Matalliotakis I, Giamarellou H, Kanellakopoulou K. Ampicillin/Sulbactam versus Cefuroxime as antimicrobial prophylaxis for cesarean delivery: a randomized study. Ziogos et al. BMC Infectious Diseases 2010, 10:341.

18. Sumiartini T, Laksmitawati D R, Ramadaniati H U, Natadidjaja R I, Asmajaya R. Pengaruh pemberian antibiotik terhadap tanda infeksi daerah operasi superfisial dan lama tinggal pasien sectio caesaria. 2021. Jakarta: Jurnal Biomedika dan Kesehatan Vol. 4 No. 1 Maret 2021.
Published
2021-10-31
How to Cite
SUMIARTINI, Teulis et al. Influence Administration of Penicillin Prophylactic Antibiotics with Cephalosporins towards The Clinical Signs of Superficial IDO and LOS to SC Patients in Hospital "X". JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 2, p. 242-247, oct. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1059>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.35814/jifi.v19i2.1059.
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Articles