Toxicity of Nanoparticles on The Spleen in Animal Studies: A Scoping Review

  • Dodi Faras Ilmiawan Sutomo Faculty of Medicine, Universitas Islam Indonesia, Sleman, D.I. Yogyakarta
  • Dwi Nur Ahsani Faculty of Medicine, Universitas Islam Indonesia, Sleman, D.I. Yogyakarta
  • Ika Fidianingsih Faculty of Medicine, Universitas Islam Indonesia, Sleman, D.I. Yogyakarta


Nanotechnology has been developing in the medical field, but some nanoparticles have toxic effects on the body, including the spleen. This scoping review represents an attempt to take stock of existing research results related to the presence or absence of toxicity to the spleen caused by nanoparticles involving experimental animals. A scoping review was conducted to synthesize and map the toxicity of nanoparticles. It has been searched on PubMed databases for spleen or lien and toxic or toxicity, and nanoparticles or dendrimers or "metal nanoparticles" or “magnetite nanoparticles” or nanoshells or “multifunctional nanoparticles” or nanocapsules or nanoconjugates or nanodiamonds or nanogels or nanospheres. Seventeen studies met our inclusion criteria. In conclusion, it showed that 13 nanoparticles could cause toxicity in rodent spleen and as many as 4 nanoparticles did not cause toxicity in rodent spleen.


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How to Cite
SUTOMO, Dodi Faras Ilmiawan; AHSANI, Dwi Nur; FIDIANINGSIH, Ika. Toxicity of Nanoparticles on The Spleen in Animal Studies: A Scoping Review. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 2, p. 158-168, oct. 2022. ISSN 2614-6495. Available at: <>. Date accessed: 08 feb. 2023. doi: