Synthesis and characterization of 2-Benzamido-NBenzylbenzamide Derivative

  • Ani Riani Hasana Fakultas Farmasi, STIKes Panti Waluya Malang
  • Siswandono Siswandono Fakultas Farmasi, Universitas Airlangga
  • Marcellino Rudyanto Fakultas Farmasi, Universitas Airlangga

Abstract

Anthranilamide derivatives exhibit anti-inflammatory, antipyretic, antibacterial, antiangiogenic, and anticoagulant properties. With an early in silico examination of its analgesic capabilities, this study aimed to generate a novel anthranilamide molecule by altering 2-Benzamido-N-Benzylbenzamide. Modification of anthranilamide with 1/2/3-chloro benzoyl chloride by acylation resulted in the design, synthesis, characterization, and research of the analgesic effects of 2-benzamido-N-benzoylbenzamide derivatives. 2-(2-chlorobenzamido)-N-(2-chlorobenzoyl)benzamide, 2-(3-chlorobenzamido)-N-(3-chlorobenzoyl)benzamide, and 2-(4-chlorobenzamido)-N-(4-chlorobenzoyl)benzamide were prepared. The nucleophilic acyl substitution reaction method was used to prepare these three chemicals by interaction with anthranylamide and benzoyl chloride molecules. Melting point and thin-layer chromatography were used to check the purity of the synthesis fi ndings. The structure was confi rmed by UV-Vis and infrared spectrophotometry.

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Published
2022-10-31
How to Cite
HASANA, Ani Riani; SISWANDONO, Siswandono; RUDYANTO, Marcellino. Synthesis and characterization of 2-Benzamido-NBenzylbenzamide Derivative. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 2, p. 281-290, oct. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1135>. Date accessed: 08 feb. 2023. doi: https://doi.org/10.35814/jifi.v20i2.1135.
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Articles