Effectivity Gel of Colocasia Esculenta (L.) Stalk for the Burn Wound Healing in Male White Rats

  • Erni Rustiani Universitas Pakuan
  • Nisa Najwa Universitas Pakuan
  • Lulu Nurzillah Universitas Pakuan
DOI: https://doi.org/10.35814/jifi.v20i1.1154

Abstract

The stalk of Colocasia esculenta (L.) plant contains flavonoids and saponins. Flavonoids presented effects in respect of the inflammatory process,  re-epithelialization and oxidative stress. Saponin not only promotes re-epithelialization of the wound but also effectively inhibits inflammatory reactions during the early phase, and promotes matrix synthesis throughout the wound healing process. So that the content of metabolites in Colocasia stalks is thought to be able to play a role in the healing process of burns, especially wounds with complications of infection. One of the topical dosage forms to treat burns is a gel dosage form. This study aimed to make and determine the effectiveness of gel of Colocasia stalk extract in healing infected burns in white male rats. The test animals were divided into five groups, each consisting of 5 rats. The groups given the gel were F1 (1% w/w), F2 (3% w/w), F3 (5% w/w). While the positive control group was given (Bioplacenton®) and the negative control group (gel base). The gel was given once a day, and the method used was the Morton method. Observations included evaluation of gel quality, decrease in wound diameter, and epithelialization time. The results showed that gel of Colocasia stalk extract  (1%, 3%, and 5% w/w) had a good quality and significantly wound infected burns (p<0.05). The decrease in wound diameter and epithelialization time had a value (p<0.05) compared to the negative control group. The healing effect of burns depends on the concentration of the dried extract of Colocasia stalk in the gel preparation. Extract concentration of 5% w/w (F3) has the most effective percentage of burn wound healing for 13 days.

References

1. Sentat T, Permatasari R. Uji aktivitas ekstrak etanol daun alpukat (Persea americana Mill.) terhadap penyembuhan luka bakar pada punggung mencit putih jantan (Mus musculus). Jurnal Ilmiah Manuntung. 2015;1(2):100-6.

2. Ananto FJ, Herwanto ES, Nugrahandhini NB, Najwa YC, Abidin MZ, Suswati I. Gel Daun Kelor Sebagai Antibiotik Alami Pada Pseudomonas aeruginosa Secara In Vivo. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia). 2015;12(1).

3. Kusuma RF, Ratnawati R, SLI DD. Pengaruh perawatan luka bakar derajat II menggunakan ekstrak etanol daun sirih (Piper betle Linn.) terhadap peningkatan ketebalan jaringan granulasi pada tikus putih (Rattus norvegicus) jantan galur Wistar. Majalah Kesehatan FKUB. 2016 Apr 26;1(2):86-94.

4. Wijaya BA. Potensi ekstrak etanol tangkai daun talas (Colocasia esculenta [L]) sebagai alternatif obat luka pada kulit kelinci (Oryctolagus cuniculus). Pharmacon. 2014;3(3).

5. Hibai AR, Herwin H, Kosman R. Antibacterial activity assay of ethanolic extract of bulbs sticky taro (Colocasia esculenta) use TLC-bioautografi. Jurnal Ilmiah As-Syifaa. 2015 Jul 1;7(1):76-84.

6. Rosyid AL, Fachriyah E, Kusrini D. Isolasi, identifikasi dan uji aktivitas senyawa triterpenoid rimpang bengle (Zingiber cassumunar Roxb.) sebagai Antibakteri. Jurnal Kimia Sains dan Aplikasi. 2016 Apr;19(1):1-6.

7. Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of food and drug analysis. 2002 Jul 1;10(3). 178 – 182.

8. Malik SK, Ahmad M, Khan F. Qualtitative and quantitative estimation of terpenoid contents in some important plants of punjab, pakistan. Pakistan Journal of Science. 2017 Jun 1;69(2):150.

9. Viscosity of Carbopol®* Polymers in Aqueous Systems TDS-730 Edition: August 13, 2010. Lubrizol

10. Departemen Kesehatan Republik Indonesia. Farmakope Herbal. Ed. I . Suppl. 3. 2013. Jakarta: Departemen Kesehatan Republik Indonesia.

11. Departemen Kesehatan Republik Indonesia. Farmakope Herbal Indonesia. Ed. I. 2008. Jakarta: Departemen Kesehatan Republik Indonesia.

12. Kuncahyo I. Optimasi campuran carbopol941 dan HPMC dalam formulasi sediaan gel ekstrak daun jambu mete secara simplex lattice design. Jurnal Farmasi Indonesia. 2011;8(1):1-2.

13. Indriaty S, Rizikyan Y, dan Firmansyah D. Formulasi dan Uji Stabilitas Gel Antingan dari Kombinasi Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus Polyhizus) dan Lendir Bekicot (Achatina Fulica) dengan Variasi Gelling Agent Carbomer 940 1%, 1,25%, 1,5% dan 1,75%. Journal of Pharmacopolium. 2019. 2 (2) : 104-111

14. Hermita N, Ningsih EP, Fatmawaty AA. Analisis proksimat dan asam oksalat pada pelepah daun talas beneng liar di kawasan Gunung Karang, Banten. Jurnal Agrosains dan Teknologi. 2018 Jan 4;2(2):95-104.

15. DepKes RI. Formularium Kosmetika Indonesia. 1985. Jakarta: Direktorat Jendral Pengawasan obat dan Makanan.

16. Nasution S. Metode Penelitian Naturalistik Kualitatif. 1992. Bandung: Tarsito.

17. Ekawati ER, Herawati D. Identifikasi kuman pada pus dari luka infeksi kulit. Jurnal SainHealth. 2018 Mar 28;2(1):31-5.

18. Pulungan AS, Brata WW. Aktivitas Antibakteri Ekstrak Etanol Daun Talas Terhadap Bakteri Patogen. Jurnal Penelitian Saintika. 2017;17(2):76-9.

19. Cowan M. Plant Product as Antimicrobial Agent. In: Rachmawati F, Cut Nuria M, Sumantri. Uji aktivitas antibakteri fraksi kloroform ekstrak etanol pegagan (Centella asiatica (l) urb) serta identifikasi senyawa aktifnya. Prosiding Seminar Nasional Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif, Semarang, Desember 2011: 7-13. ISBN: 978-602-19556-0-4

20. Fitri N. Penggunaan Krim Ekstrak Batang dan Daun Suruhan (Peperomia pellucida LHB K) dalam Proses Penyembuhan Luka Bakar pada Tikus Putih (Rattus norvegicus). Jurnal Biopendix. 2015.2(1) : 193–203.

21. Putri FR, Tasminatun S. Efektivitas salep kitosan terhadap penyembuhan luka bakar kimia pada Rattus norvegicus. Mutiara Medika: Jurnal Kedokteran dan Kesehatan. 2012;12(1):24-30.
Published
2022-04-29
How to Cite
RUSTIANI, Erni; NAJWA, Nisa; NURZILLAH, Lulu. Effectivity Gel of Colocasia Esculenta (L.) Stalk for the Burn Wound Healing in Male White Rats. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 1, p. 93-100, apr. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1154>. Date accessed: 24 nov. 2024. doi: https://doi.org/10.35814/jifi.v20i1.1154.
Citation Formats
Issue
Vol 20 No 1 (2022): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.