Brewed of Red Rosella Calyx Powder Prevent Decrease HDL on Sprague dawley Given Waste Cooking Oil

  • Arya Ulilalbab Program Studi S1 Gizi, Institut Ilmu Kesehatan Bhakti Wiyata Kediri
  • Eni Maskanah Program Studi D3 Gizi, Akademi Gizi Karya Husada Kediri
DOI: https://doi.org/10.35814/jifi.v19i2.1158

Abstract

Lipid metabolism disorder is caused by waste cooking oil that is one of the source of exogenous free radicals. Publics know the utilization of red rosella calyx is used as a brew that contains antioxidants. Purpose of this research is to find out the effect of giving brewed red rosella calyx to rat lipid metabolism caused by waste cooking oil on High-density Lipoprotein (HDL) value. This research used 24 male rats which were selected by random sampling and divided into 4 groups: positive control (2 ml kg/BW waste cooking oil given), negative control (without treatment), treatment 1 (2 ml/kg BW waste cooking oil given and giving of 540 mg/kg BW brewed red rosella calyx), and treatment 2 (2 ml/kg BW waste cooking oil given and giving of 810 mg/kg BW brewed red rosella calyx). One-way Analysis of Variance (α = 0.01) and Tukey honestly significant difference test showed that HDL p-value = 0.00. All groups have a significant effect on HDL. The best value is giving of 810 mg/kg BW dose of brewed red rosella calyx (HDL of 57.47 mg/dl). Giving of brewed red rosella calyx dose of 540 mg/kg BW (EC50 = 407.52 bpj) and red rosella calyx dose 810 mg/kg BW (EC50 = 247.82 bpj) can prevent HDL decrease. Red rosella calyx can improve the lipid profile of waste cooking oil treated to Sprague Dawley rats (especially for HDL on this research).

References

1. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Riset kesehatan dasar (RISKESDAS) 2013. Jakarta. 2013.

2. PERKENI. Panduan pengelolaan dislipidemia di Indonesia 2015. Perhimpunan Endokrinologi Indonesia, PB. PERKENI. 2015.

3. Ganong, WF. Buku Ajar Fisiologi Kedokteran Edisi 23. Jakarta: Penerbit EGC. 2010.

4. Dhuley, J, Naik SR, Rele S and Benerji A. Hypolipidemic and antioxidant activity of diallyl disulphide in rats. Pharmacy and Pharmacology Communications. 1999. 5(12):689-96.

5. Labarthe D. Epidemiology and prevention of cardiovascular disease: A global challange 2nd ed: Jones Bartlett Publishers. 2011.

6. Ochani, P.C and D’Mello, P. Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and calyces extract in rats. Indian Journal of Experimental Biology. 2009. 47(4):276-82.

7. Ulilalbab A, Priyanto AD, Maulana HI, Puspitasari FR, Fitriani E, and Estiasih T. 2012. Pemberian tablet effervescent rosella ungu menurunkan nilai MDA (malondialdehid) tikus wistar yang dipapar minyak jelantah. The Indonesian Journal of Public Health. 2012. 9(1):81-6.

8. Maulana, HI, Ulilalbab A, Priyanto AD, and Estiasih T. Effervescent rosela ungu mencegah penurunan nilai SOD dan mencegah nekrosis hepar tikus wistar yang diberi minyak jelantah. Jurnal Kedokteran Brawijaya. 2014. 28(2):85-90.

9. Benhar, M., Engelberg D, dan Levitski A. Reactive oxygen species (ROS), stress-activated kinases and stress signaling in cancer. EMBO reports. 2002. 3(5):420-5.

10. Ulilalbab, A, Wirjatmadi B, and Adriani, M. Ekstrak Kelopak Rosella Merah Mencegah Kenaikan Malondialdehid Tikus Wistar yang Dipapar Asap Rokok. Jurnal Ilmu Kefarmasian Indonesia. 2015. 13(2):215-20.

11. Oktaviani, ND. Hubungan lamanya pemanasan dengan kerusakan minyak goreng curah ditinjau dari bilangan peroksida. Jurnal Biomedika. 2009. 1(1):31-5.

12. Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, et al. Hypocholesterolemic and antioxidant effect of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. Journal of Ethnopharmacology. 2006. 103(2):252-60.

13. Maryani H, dan Kristina L. Khasiat dan manfaat rosela. Jakarta Selatan: Agromedia. 2008.

14. Lee CH, Kuo CY, Wang CJ, Wang CP, Lee YR, Hung CN, et al. A polypenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro. Biosci. Biotechnol. Biochem. 2012. 76(4):646–51.
Published
2021-10-31
How to Cite
ULILALBAB, Arya; MASKANAH, Eni. Brewed of Red Rosella Calyx Powder Prevent Decrease HDL on Sprague dawley Given Waste Cooking Oil. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 2, p. 262-265, oct. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1158>. Date accessed: 20 apr. 2024. doi: https://doi.org/10.35814/jifi.v19i2.1158.
Citation Formats
Issue
Vol 19 No 2 (2021): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.