Formulation of Moisturizer Cream Containing Orange Melon (Cucumis melo L. var. reticulatus) Fruit Extract

  • Mellisa Laura Mintoro Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
  • Farida Lanawati Darsono Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya
  • Sumi Wijaya Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya

Abstract

Environmental factors such as extreme sunlight may disrupt skin’s moisture balance and cause the skin to dry out. Therefore, skincare products such as moisturisers are highly needed. In this study, orange melon (Cucumis melo L. var. reticulatus) was added to increase the value of the moisturiser product. Orange melon contains sucrose as the moisturising substance and antioxidant substance which helps to normalize the skin. The extraction process was carried out using juicer. The fruit extract was used at 10% (FI), 20% (FII), and 30% (FIII). This study aims to know the impact of increasing orange melon extract concentration on the physical characteristics of cream and its moisturising effect and antioxidant activity as well as the best formula. The evaluations consisted of physical characteristics, moisturising effect, and antioxidant test with DPPH method. The statistical results showed that the increase in extract concentration significantly affect the physical characteristics (pH, viscosity, spreadibility, ease of removal, adhesivity) and moisturising effect of the creams. Increasing extract concentration would cause a significant increase in the moisturising effect of creams containing synthetic humectants. The best formula which fulfilled the requirements of physical characteristics and effectiveness test, while possessing antioxidant effect was F2 (20% orange melon extract).

References

1. Masnec LS, Situm M. Skin aging. ACTA Clinica Croatica. 2010. 49: 515-519.

2. Mathlouthia M, Genotelleb J. Role of water in sucrose crystallization. Carbohydrate Polymers. 1998. 37: 335-342.

3. Burger Y, Saar U, Nurit K. A single recessive gene for sucrose accumulation in Cucumis melo fruit. Journal of American Society for Horticultural Science. 2002. 127(6): 938-943.

4. US Department of Agriculture (USDA), Classification for Kingdom Plantae Down to Genus Cucumis L. USDA Natural Resources Conservation Service. Washington D.C. diambil dari http://www.ars.usda.gov/ba/bhnrc/ndl. Diakses pada 25 September 2021.

5. Devi V, Sharmila S, Divyapriya S. Invitro cytotoxicity and free radical scavenging activity of aqueous extract of Cucumis melo. International Journal of Pharmaceutical and Biological Research (IJPBR). 2011. 2(6): 150-156

6. Hidayatullah S. Statistika Farmasi. Edisi Pertama.Yogyakarta. Innosain. 2018.

7. Weihong GM. Comparison of Stacking and Nonstacking on Melon and Musk melon (Cucumis melo) Production. ARC Training, New York. 1996.

8. Direktorat Jenderal Pengawasan Obat dan Makanan Republik Indonesia (DitJen POM RI). Parameter Standar Umum Ekstrak Tumbuhan Obat. Cetakan Pertama. Jakarta: Departemen Kesehatan Republik Indonesia. 2000.

9. Ittiyavirah S, George A, Santhosh A, Kurian S, Pappachan P, Jacob G. Studies of cytotoxic potential of Cucumis melo Linn. fruit aqueous extract. Iranian Journal of Pharmacology and Therapeutics. 2012. 12: 24-29.

10. Rawlins EA. Bentleys of Pharmaceutics. 8th ed. London Baillierre Tindal. 2010.

11. Singh M, Sharma S, Khokra SL, Sahu RK, Jangde R. Preparation and evaluation of herbal cosmetic cream. Pharmacology Online. 2011. 2: 1258-1264

12. Aswal A, Kalra M, Rout A. Preparation and evaluation of polyherbal cosmetic cream, Der Pharmacia Lettre. 2013. 5(1): 83-88.

13. Departemen Kesehatan Republik Indonesia (DepKes RI). Formularium Kosmetika Indonesia. Cetakan I. Jakarta. Departemen Kesehatan Republik Indonesia. 1985.

14. Akash S, Karekar P, Yadav A. Formulation and evaluation of multipurpose herbal cream. International Journal of Science and Research (IJSR). 2015. 4(11):12.

15. Hajare M, Nitalikar M, Mohite M, Shid SJ, Dange VN. Formulation and optimization of dermatological dosage form for comparative in-vitro evaluation of semisolid bases. Research Journal of Topical and Cosmetic Sciences. 2016. 4(1): 1-4.

16. Kulkarni RV, Sreedhar V, Mutalik S, Setty M, Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of Prazosin Hydrochloride through skin. International Journal of Biological Macromolecules. 2010. 47:520–527.

17. Lachman L, Lieberman AH, Kanig JL. The Theory and Practice of Industrial Pharmacy. Diambil dari : https://www.hktechnical.com/2021/03/free-pdf-lachmans-theory-and-practice.html. Diakses pada 25 Maret 2022.

18. Martin AN, Swarbick J, Camarata A. Physical Pharmacy. Diterjemahkan dari Bahasa Inggris oleh Yoshita. Edisi 3. Penerbit Universitas Indonesia (UI Press). Jakarta. 2011.

19. Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipient. 9th ed. Pharmaceutical Press and American Pharmacist Association. London. 2020.

20. Battistel MD, Pendrill R, Widmalm G, Freedberg DI. Direct evidence for hydrogen bonding in Glycans: A combined NMR and Molecular Dynamics Study. Journal of Physical Chemistry B. 2013. 117(17): 4860-4869.

21. White JS. ‘Sucrose, HFCS, and Fructose: History, Manufacture, Composition, Applications, and Production’ dalam White JS, Rippe J. (eds.). Fructose, High Fructose Corn Syrup, Sucrose and Health. Humana Press. New York. 2014.

22. Widowati W, Widyanto RM, Laksmitawati DR, Erawijantari PP, Wijaya L, Sandra F. Phytochemical, free radical scavenging, and cytotoxic assay of Cucumis melo L. extract and β-carotene. Journal of Advanced Agricultural Technologies. 2015. 2(2):16.

23. Beaulieu JC, Grimm CC. Identification of volatile compounds in Cantaloupe at various developmental stages using solid phase microextraction. Journal of Agricultural and Food Chemistry. 2001. 49:1345-1352.

24. Lamikanra O,Watson MA. Cantaloupe melon peroxidase: characterization and effects of additives on activity. 2000. Nahrung, 44(3): 168-172.

25. Young A. Practical Cosmetic Science. 2nd ed. Mills and Boon Limited Publisher. London. 2002.

26. Aulton M, Taylor K. Aulton’s Pharmaceutics: The Design and Manufacture of Medicine. 6th ed. Churchill Livingstone. Leicester. 2021.
Published
2022-10-31
How to Cite
MINTORO, Mellisa Laura; DARSONO, Farida Lanawati; WIJAYA, Sumi. Formulation of Moisturizer Cream Containing Orange Melon (Cucumis melo L. var. reticulatus) Fruit Extract. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 2, p. 291-301, oct. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1164>. Date accessed: 08 feb. 2023. doi: https://doi.org/10.35814/jifi.v20i2.1164.
Section
Articles