Antioxidant Effect of Cosolvent Solution of Mangosteen (Garcinia mangostana L.) Rind Extract in Rats by Using MDA and SOD Parameter

  • ROS SUMARNY UNIVERSITAS PANCASILA
  • LILIEK NURHIDAYATI UNIVERSITAS PANCASILA
  • SITI SOFIAH UNIVERSITAS PANCASILA
  • YATI SUMIYATI UNIVERSITAS PANCASILA
  • FRANSISKA DIANA SANTI UNIVERSITAS PANCASILA

Abstract

 Mangosteen (Garcinia mangostana L.) rinds extract in capsule form has been marketed. a-mangostin, the active compound of G. mangostana had been known has low solubility in water. This study was aimed to measure and compare antioxidant effect of a-mangostin as cosolvent solution to extracts suspentions. 25 rats were divided into 5 groups: negative (I) and positive (II) control, cosolvent solution (III), extract (IV) and extract® (V). Treatment were given for 14 days, free radicals were induced by CCl . MDA were analyzed using thiobarbituric acid method while SOD by using adenochrome assay. Results showed MDA level were: 1.0±0.19; 0.3±0.05; 0.4±0.04; 0.6±0.04 and 0.5±0.00 nmol/mL, whereas SOD activity were: 17±0.0; 123±25.3; 107±19.0; 73±18.9 and 97±27.0 U/mL for group I, II, III, IV and V, respectively. Kruskal Wallis test showed a significant difference in MDA between group III with IV and V (p>0.05), showing cosolvent has higher ability to decrease MDA than the extracts suspension. There were significant differences of SOD between group III and IV (p>0.05), meaning cosolvent has higher ability to increase SOD activity compare to the extracts. Research showed cosolvent has a higher antioxidant effect with potential to inhibit MDA formation by 70% and increase SOD activity by 623%. 

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How to Cite
SUMARNY, ROS et al. Antioxidant Effect of Cosolvent Solution of Mangosteen (Garcinia mangostana L.) Rind Extract in Rats by Using MDA and SOD Parameter. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 13, n. 1, p. 35-39, apr. 2015. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/117>. Date accessed: 25 feb. 2024.
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