The Utilization of Rosella (Hibiscus Sabdariffa Linn.) Calyx Extract to Increase Hemoglobin and Hematocrit of Female Adolescents Anemia

  • Luluk Handayani Poltekkes of Health Ministry Semarang
  • Sri Sumarni Poltekkes of Health Ministry Semarang
  • Donny Kristanto Mulyantoro Research and Development Center of Health Magelang

Abstract

This research aims to prove the provision benefits of Rosella (Hibiscus sabdariffa Linn.) calyx extract to increase hemoglobin and hematocrit levels in female adolescents anemia. This research is a true experiment with a randomized pre-test and post-test control group design. Totals of samples were 40 female adolescents with anemia according to the inclusion and exclusion criteria divided by randomization sampling technique, consisting of two groups intervention groups and control groups. Data analysis used paired t-test statistical test to determine the difference between pretest and post-test each group and an independent t-test to determine the difference between the different groups. The average difference in hemoglobin and hematocrit levels in the intervention group was higher than in the control group. The average difference in hemoglobin levels in the intervention group was 1.8 g/dL in and the control group was 0.9 g/dL, (p < 0.05), The difference in the average hematocrit level in the intervention group was 5.6% and the control group was 2.7% (p < 0.05). The researchers also found significant statistics differences between hemoglobin and hematocrit levels of female adolescents from intervention and control groups s with a p-value < 0.05. The combination of Rosella (Hibiscus sabdariffa Linn.) calyx extract and Fe2+ tablet was effective to increasing hemoglobin and hematocrit levels in female adolescents with anemia.

References

1. Setiati S, Wisaksono SA, Setiyahadi B, Alwi; I, Simadibrata; M, Ari Fahrial Syam. Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: Internal Publishing, Departement of Internal Medicine; 2017.

2. WHO. Global Nutrition Targets 2025: Anemia Policy Brief Series. World Heal Organ. 2014;2(6):375–88.

3. Kemenkes RI. Survei Demografi dan Kesehatan Indonesia 2017. Badan Kependud dan Kel Berencana Nasional, Badan Pus Stat Kementeri Kesehat. 2018;

4. Kemenkes RI. Profil Kesehatan 2018. Pertama. drg. Rudy Kurniawan, M.Kes Yudianto, SKM, M.Si Boga Hardhana, S.Si, MM Tanti Siswanti, SKM MK, editor. Kementerian Kesehatan Republik Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018. 556 p.

5. Briawan D. Anemia: Masalah Gizi pada Remaja. Jakarta: Buku Kedokteran EGC; 2013.

6. Kementerian Koordinator Bidang Kesejahteraan Rakyat. Kerangka Kebijakan Gerakan Nasional Percepatan Perbaikan Gizi dalam Rangka Seribu Hari Pertama Kehidupan (Gerakan 1000 HPK). 2013;71.

7. Andaruni NQR, Nurbaety B. Efektivitas Pemberian Tablet Zat Besi (Fe), Vitamin C Dan Jus Buah Jambu Biji Terhadap Peningkatan Kadar Hemoglobin (Hb) Remaja Putri Di Universitas Muhammadiyah Mataram. Midwifery J J Kebidanan Univ Muhammadiyah Mataram. 2018;3(2):104.

8. Delima, Widowati L, Astuti Y, Siswoyo H, Gitawati R, Purwadianto A. Gambaran Praktik Penggunaan Jamu Oleh Dokter di Enam Provinsi di Indonesia. Bul Penelit Sist Kesehat. 2012;109–22.

9. Apul S, Sisilia FY. The utilization of red seed guava and rosella flower as sources of vitamin C. IOP Conf Ser Earth Environ Sci. 2018;205(1).

10. Patel S. Hibiscus sabdariffa: An ideal yet under-exploited candidate for nutraceutical applications. Biomed Prev Nutr. 2014;4(1):23–7.

11. Sembiring A, Tanjung M, Sabri E. Pengaruh Ekstrak Segar Rosela (Hibiscus Sabdariffa L.) terhadap Jumlah Eritrosit dan Kadar Hemoglobin Mencit Jantan (Mus Musculus L.) Anemia Strain Ddw melalui Induksi Natrium Nitrit (Nano2). Saintia Biol. 2013;1(2):60–5.

12. Kholis N. Bebas Kanker Seumur Hidup dengan Terapi Herbal. Yogyakarta: Real Books Rosella; 2011.

13. Anel TC, Thokchom R, Subapriya MS, Thokchom J, Singh SS. Hibiscus sabdariffa -A natural micro nutrient source. Int J Adv Res Biol Sci. 2016;3(4):243–8.

14. Nurjanah FW, Hadisaputro S, Fatmasari D. Long Bean Leaf Extract for Improving Haematological Status of Female Adolescent with Anemia that Gets Fe Supplementation. J Kesehat Masy. 2020 Jul;16(1):81–7.

15. Nisa J. Perilaku Konsumsi Sumber Enhancer Dan Inhibitor Fe Dengan Kejadian Anemia Pada Kehamilan. Siklus J Res Midwifery Politek Tegal. 2019;8(1):41.

16. Obouayeba AP, Djyh NB, Diabate S, Djaman AJ, N’Guessan JD, Kone M, et al. Phytochemical and antioxidant activity of roselle (Hibiscus Sabdariffa L.) calyx extracts. Res J Pharm Biol Chem Sci. 2014;5(2):1453–65.

17. Nisa R, Soejoenoes A, Wahyuni S. Effect of Roselle (Hibiscus Sabdariffa) on Changes in Hemoglobin Levels in Pregnant Women With Anemia Taking Iron Supplement. Belitung Nurs J. 2017;3(6):771–7.

18. Mizawati F, Savitri W, Wulandari R. Efektifitas Bunga Rosella terhadap Perubahan Tingkat Hemoglobin pada Ibu Hamil yang Mengkonsumsi Tablet Fe di Wilayah Puskesmas Ratu Agung. J Ners dan Kebidanan. 2020;

19. Malisan E, Wantania FE, Rotty LW., Dkk. Hubungan Kadar Hematokrit dengan Kelas Nyha pada Pasien Gagal Jantung Kongestif Obesitas Sentral yang Dirawat Jalan dan Dirawat Inap di RSUP. Prof. Dr. R.D Kandou. Jurnal e-Clinic (eCl). 2015;3:2.
Published
2022-04-29
How to Cite
HANDAYANI, Luluk; SUMARNI, Sri; MULYANTORO, Donny Kristanto. The Utilization of Rosella (Hibiscus Sabdariffa Linn.) Calyx Extract to Increase Hemoglobin and Hematocrit of Female Adolescents Anemia. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 1, p. 107-112, apr. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1213>. Date accessed: 02 july 2022. doi: https://doi.org/10.35814/jifi.v20i1.1213.
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Articles