In Vivo Incision Wound Healing Studies using Ethanolic Cinnamon’s (Cinnamomum burmannii) Leaves Extract in White Male Rats

  • Fathnur Sani Kasmadi Pharmacy Study Program, Faculty of Medicine and Public Health Sciences, Jambi University
  • Nada Afrilia Pharmacy Study Program, Faculty of Medicine and Public Health Sciences, Jambi University
  • Diah Tri Utami Pharmacy Study Program, Faculty of Medicine and Public Health Sciences, Jambi University
  • Yuliawati Yuliawati Pharmacy Study Program, Faculty of Medicine and Public Health Sciences, Jambi University


Cinnamon leaves are traditional plants that contain secondary metabolites such as flavonoids,

tannins, saponins, alkaloids, and phenols. All of these compounds play an essential role in the wound healing process. This study aimed to determine the effects of cinnamon (Cinnamomum burmannii) on incision wound healing in male rats. The research method used a post-test only control group design approach that uses five treatment groups: positive control (Bioplacenton® Gel), negative control (Vaseline flavum), and ethanol extract of cinnamon leaves at concentrations of 10%, 20%, and 30%. The results showed that the ethanol extract of cinnamon leaves affected wound healing, as observed from the day of wound healing, the AUC length of the wound, and levels of hydroxyproline. The statistical test results showed a significant difference between the groups (p<0.05), where the best concentration was 30%, followed by 20% and 10%. Therefore, we concluded that the ethanolic extract of cinnamon leaves can heal wounds in male rats.


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How to Cite
KASMADI, Fathnur Sani et al. In Vivo Incision Wound Healing Studies using Ethanolic Cinnamon’s (Cinnamomum burmannii) Leaves Extract in White Male Rats. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 2, p. 196-200, oct. 2022. ISSN 2614-6495. Available at: <>. Date accessed: 16 apr. 2024. doi: