Utilization of Chitosan Cross-Linked with Tripolyphosphate as The Excipient of Snakehead Fish (Channa Striatus) Gel

  • DINA RAHMAWANTY Universits Lambung Mangkurat


 Meat of snakehead fish (Channa striatus) has been reported can be used for wound healing  because contains proteins, essential amino acids, lipid and fatty acids that inuenced wound healing process. The present study was performed in order to formulate gels contain meat powders of snakehead fish for wound healing. The formulas were used 1 g (formula 1) and 2 g (formula 2) meat powder of snakehead fish as an active ingredient. Meat powder of snakehead fish have been made nanosuspension use ionic gelation method with chitosan and  sodium tripolyphosphate and formulated to gel form using HPMC as gelling agent. Suspenses have been physicochemical charactheried. The results showed that suspenses (formula 1 and formula 2) have particle sie in range of 41.665.5 nm and 41.2.1 nm respectively polidispersity inde of 0.512 and 0.456 respectively eta potential ()2.15 m and ()2.35 m respectively both of formulas have spherical particles.


1. Mat Jais, AM. Haruan, Channa striatus farming in Backyard. Proceeding of the Third Asian Conference of Technology for Rural Development. 11. 1, 2302.
2. Mat Jais, AM. McCullok R, Croft K. Fatty acid and amino acid composition in Haruan as a potential role in wound healing. General Pharmacology. 14. (25): 947-50.
3. Avadi MR, Sadeghi AM, Mohammadpour N, Abedim S, Atyabi F, Dinarvand R, Tehrani RM. Preparation and characteriation of insulin nanoparticles using chitosan and arabic gum with ionic gelation method. Nanomedicine. 200(6):563.
4. Jahanshahi, Babaei. Protein nanoparticle: A unique system as drug delivery vehicles. J Biotech. 200. 7(25):42634.
5. Amalia H. Preparasi gel nanopartikel kofein menggunakan metode gelasi ionik kitosan natrium tripolifosfat dan uji penetrasi in vitro dengan sel difusi fran. Jakarta: Fakultas Farmasi Universitas Indonesia 2013.
6. Iswandana R, Anwar E, Jufri M. Nanoparticles formulation from chitosan and sodium tripolyphosphate by ionic gelation method using verapamil hydrochloride as drug model. 24th FAPA Congress, Bali-Indonesia. 2012.
7. Martin A, Swarbrick J, Cammarata A. Farmasi fisik. Jilid II. Ed. III. Jakarta: UI Press 13. 324.
How to Cite
RAHMAWANTY, DINA; ANWAR, EFFIONORA; BAHTIAR, ANTON. Utilization of Chitosan Cross-Linked with Tripolyphosphate as The Excipient of Snakehead Fish (Channa Striatus) Gel. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 13, n. 1, p. 76-81, apr. 2015. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/128>. Date accessed: 02 dec. 2020.