Molecular Mechanisms of Network Pharmacology-Based Immunomodulation of Huangqi (Astragali Radix)

  • Raymond Rubianto Tjandrawinata Fakultas Bioteknologi, Universitas Katolik Indonesia Atma Jaya
  • Anindini Winda Amalia Pengobatan Tradisional Tiongkok/Fakultas Kesehatan Institut Ilmu Kesehatan Bhakti Wiyata
  • Hartati Tuna Pengobatan Tradisional Tiongkok/Fakultas Kesehatan Institut Ilmu Kesehatan Bhakti Wiyata
  • Viedya Novalinda Said Pengobatan Tradisional Tiongkok/Fakultas Kesehatan Institut Ilmu Kesehatan Bhakti Wiyata
  • Santi Tan Dexa Laboratories of Biomolecular Sceinces, Dexa Group

Abstract

Astragali Radix (Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, also known as Huangqi) has been used to improve stamina and immunity for thousands of years. However, the bioactive components and their mechanisms are still unclear, limiting its clinical application. In this research, for the first time, network pharmacology was used to investigate the molecular mechanisms of Huangqi and its bioactive components that play an important role in improving the immune system. An amount of 1,430 immunomodulation-related target proteins was collected from the human genome database, with 171 target proteins from 20 bioactive components, and resulted in 60 intersection target proteins. Subsequently, the networks of common target and protein-protein interaction (PPI) were analyzed. The results showed that Huangqi influenced the modulations of lymphocytes (B cells and T cells), natural killer cells, macrophages, cytokines, immunoglobulins, and immune signal transduction. To a certain limit, this study revealed the potential bioactive components and pharmacological mechanisms of Huangqi in immunomodulation. It was able to direct novel drug development for treating immune system deficiency.

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Published
2022-10-30
How to Cite
TJANDRAWINATA, Raymond Rubianto et al. Molecular Mechanisms of Network Pharmacology-Based Immunomodulation of Huangqi (Astragali Radix). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 20, n. 2, p. 184-195, oct. 2022. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1301>. Date accessed: 08 feb. 2023. doi: https://doi.org/10.35814/jifi.v20i2.1301.
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