Preparation of Oral Nutraceutical from Gambier Extract

  • GALUH WIDIYARTI Pusat Penelitian Kimia LIPI
  • ANDINI SUNDOWO Pusat Penelitian Kimia LIPI
  • MARISSA ANGELINA Pusat Penelitian Kimia LIPI

Abstract

 Catechin is one of bioactive compounds in gambier. Result of preliminary studies showed that catechin is active as an antioxidant and antibacterial, thus it was potential as an oral nutraceutical for prevention of dental plaque. In present study, preparation of the oral nutraceutical in the form of mouthwash was performed by variating content of catechin in the extract as formulation parameter. The contents of catechin in the mouthwash solution are 0.01-0.1% (w/v). The mouthwash products were analyzed for pH, antioxidant and antibacterial activities, also particle size. The results showed that mouthwash with catechin content of 0.01-0.08% (w/v) produced the nanoscale of the particle size of mouthwash.

References

1. Anonim. SNI Gambir: SNI 01-3391-2000. Jakarta: Badan Standarisasi Nasional; 2000. 1-6.
2. Risdale CE. A review of Uncaria rubiaceae. J. of Blumea. 2002.24:43-100.
3. Arakawa H, Masako M, Robuyusi S, and Miyazaki. Role of hydrogen peroxide in bactericidal action of catechin. Biologic and Pharmaceutic Bull. 2004. 3227(27): 227–88.
4. Rindit P, Murdjiati G, Slamet S, dan Kapti RK. Kandungan fenol dan sifat antibakteri dari berbagai jenis ekstrak produk gambir (U. gambier Roxb).
Majalah Farmasi Indonesia. 2007.18(3):141-6.
5. Sang S, Cheng X, Stark RE, Rosen RT, Yang CS, Ho CT. Chemical studies on antioxidant mechanism of tea catechin: analysis of radical reaction products of catechin and epicatechin with 2,2-diphenyl-1- picrylhydrazyl. J. Of Bioorganic and Med. Chem. 2002.10:2233-7.
6. Anonim. Data sentra produksi gambir dan ekspor gambir. Jakarta: Ditjenbun; 2006.
7. Gumbira ES. Review kajian penelitian dan pengembangan agroindustri strategis nasional: kelapa sawit, kakao, dan gambir. J Tek Ind Pert. 2009.19(1):45-55.
8. Kozai K., Soto M, Yamaguchi N, and Nagasaka N. Potential of gambier as an inhibitor of dental plaque Formation. Dent.J. 1995.28(3):93-6.
9. Kresnawaty I dan Zainudin A. Aktivitas antioksidan dan antibakteri dari derivat metil ekstrak etanol daun gambir (Uncaria gambir). J.Littri. 2009.5(4):145-51.
10. Widiyarti G, Sundowo A, and Hanafi M. The free radical scavenging and anti-hyperglycemic activities of various gambiers available in Indonesian Market. Makara Sains. 2011.15(2):129-34.
11. Ibsen RL, Glace WR, and Pacropis DL. Antibacterial moutwash. EP. 0.666.731. B1. 2004.1-9.
12. Anonim. SNI Termogravimetri dan Pengabuan: SNI 01-2891-1992. Jakarta: Badan Standarisasi Nasional; 1992.
13. Yen G and Chen H. Antioxidant activity of various tea extract in relation to their antimutagenicity. J Agric Food Chem. 1995.4:27-32.
14. Harbone JB and Dey PM. Metode fitokimia: Penuntun cara menganalisis tumbuhan, diterjemahkan oleh Kosasih Padmawinata. Bandung: Penerbit ITB; 1987. 47-109.
15. Black JG. Microbiology principles and application. Lebanon: Practice Hall; 1993. 186-7, 359-61.
16. Eni H. Analisa kadar catechin dari gambir dengan berbagai metode. Bull. Tek. Pert. 2003.8(1):31-3.
17. Depkes RI. Farmakope Indonesia Edisi IV. Jakarta: Depkes RI; 1995.
18. Bahna P, Hanna HA, Dvorak T, Vaporciyan A, Chambers M, and Raad I. Antiseptic effect of a novel alcohol-free mouthwash: A convenient prophylactic alternative for high risk patients. Oral Oncology J. 2007.43:159-64.
19. Lucida H, Bakhtiar A, dan Putri WA. Formulasi sediaan antiseptik mulut dari katekin gambir. J Sains Tek Far. 2007.12(1):1-7.
20. Roslan ANB, Sunariani J, dan Irmawati A. Penurunan sensitivitas rasa manis akibat pemakaian pasta gigi yang mengandung sodium lauril sulfat 5%, J.PDGI, 2009.58(2):10-3.
21. Peraturan Menteri Kesehatan RI No.1168/Menkes/ Per/X/1999. Bahan Tambahan Makanan. 1999.
22. Tisnawati.Teknik penggunaan sodium benzoat untuk memperpanjang peragaan bunga sedap malam. Bull. Tek. Pert. 2005.10.
23. Solans C and Sole I. Nano-emulsions: Formation by low-energy methods. Current Opinion in Colloid & Interface Science. 2012.17:246–54.
Published
2014-09-30
How to Cite
WIDIYARTI, GALUH; SUNDOWO, ANDINI; ANGELINA, MARISSA. Preparation of Oral Nutraceutical from Gambier Extract. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 12, n. 2, p. 145-153, sep. 2014. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/136>. Date accessed: 26 apr. 2024.
Section
Articles