Hair Growth Activity of Hair Tonic Preparations Containing Cinnamon Essential Oil (Cinnamomum burmanii) and Virgin Coconut Oil
Abstract
Cinnamaldehyde in cinnamon essential oil, lauric acid, myristic acid, and oleic acid in virgin coconut oil (VCO) were used in hair tonic preparations as hair growth agents. This study aimed to evaluate particle size and obtain optimum formulation of the hair tonic preparation and to observe growth activity with various levels of cinnamon essential oil and VCO. This research an experimental with rabbit used 4 test were divided into 6 treatment groups: 1) positive control (Regrou®); 2) normal control (without treatment); 3) negative control (hair tonic basis); 4) F1(1% cinnamon essential oil: 2.5% VCO); 5), F2 (3% cinnamon essential oil : 2.5% VCO); and 6), F3 (5% cinnamon essential oil: 2.5% VCO). The particle size analysis selected in formula 2 that cycle stable during storage, and fall into the microemulsion size range of 20-200 nm and there was no difference cycle because the significance was >0.05. The hair growth activity was determined using Average Growth Daily Gain.(AGD) formula and then.was analyzed.statistically using.One Way Anova. The results showed that had hair growth activity that was not significantly different. However, when compared with the positive control, formula 3 has hair growth activity above the positive control.
References
2. Sumayyah, S., and Salsabila, N., 2017, Traditional medicine: Between efficacy and side effects, Journal of Pharmacy Magazine, 2, 2-4.
3. Khasanah, L.U., Utami, R., Kawiji, and Manuhara, G.J., 2021, Characterization of cinnamon bark hydrosol (Cinnamomum burmannii) on various variations of pilot plan-scale steam distillation valve openings, Journal of Agricultural Products Technology, 14, 24-28.
4. Trueb, R.M., 2009, Oxidative stress in aging of hair, International Journal of Trichology, 1, 7-12.
5. Indirana, L., Pangkahila, W., and Aman, I.G.M., 2018, Topical Application of cinnamon (Cinnamomum burmanii) essential oil has the effectiveness as minoxidil in increasing hair lenght and diameter size of hair follicles in male white wistar rats (Rattus Norvegicus), Indonesian Journal of Anti-Aging Medicine, Vol 2(1).
6. Toruan EW. Differences in serum levels of steroid 5α-reductase type 2 (Srd5a2) in men with and without androgenetic alopecia. 2020.
7. Hindun S, akmal A, Sari N. Formulation of hair tonic combination of celery and green tea leaves ethanol extract for rabbit hair growth. J Ilm Farm Bahari. 2017;8:21–33.
8. Novianti V, Thauresia S, Simanjuntak P. Test activities of hair tonic that contain water fractions that contain flavonoid from green tea leaf ethanol extract ( Camellia sinensis L .). 2019;VI(1):22–8.
9. Sugest R, Wulandari FT, Rini DS. Karakteristik hair tonic menggunakan minyak kayu putih (Melaleuca sp) sebagai bahan aktif. Semant Sch. 2018;1–10.
10. Jha SK, Dey S, Karki R. Microemulsions- potential carrier for improved drug delivery. Asian J Biomed Pharm Sci. 2011;1(1):5–9.
11. Talegaonkar S, Azeem A, Ahmad F, Khar R, Pathan S, Khan Z. Microemulsions: A novel approach to enhanced drug delivery. Recent Pat Drug Deliv Formul. 2008;2(3):238–57.
12. Lucida H, Salman, Hervian MS. Penetration enhancement test of virgin coconut oil (VCO) in cream base. J Sains Tek Far. 2008;13(25).
13. Satheeshan K, Seema B, Manjusha AM. Development and evaluation of VCO based herbal hair tonic. Int J Sci Res Sci Technol. 2020;9(2):485–93.
14. Budiman A, Faulina M, Khoirunnisa A. Surgery for Atrial Fibrillation. Atlas of Cardiac Surgical Techniques. 2015. p. 479–88.
15. Farmakope Indonesia. edisi 4. Jakarta: departemen kesehatan RI; 1995. 1039–1040 p.
16. Akib N illiyin, Tendri Adjeng AN, Lakasa RP, Suryani S, Sartinah A, Ritonga H, et al. Physical stability of hair tonic contain ethanol extract galangal (Alpinia galanga L.) rhizome and aloe vera leaf filtrate (Aloe vera L.). Pharmauho J Pharmacy, Sci Heal. 2020;6(2):69.
17. Nuraeni W, Daruwati I, W EM, Sriyani ME. Verifikasi kinerja alat particle size analyzer (PSA) horiba lb-550 untuk penentuan distribusi ukuran nanopartikel. Pros Semin Nas Sains dan Teknol Nukl. 2013;266–71.
18. Fajar A, Ammar GA, Hamzah M, Manurung R, Abduh MY. Effect of tree age on the yield, productivity, and chemical composition of essential oil from Cinnamomum burmannii. Curr Res Biosci Biotechnol. 2019;1(1):17–22.
19. Baskara IBB, Suhendra L, Wrasiati LP. Pengaruh suhu pencampuran dan lama pengadukan terhadap karakter¬istik sediaan krim. J Rekayasa dan Manaj Agroindustri. 2020;8(2):200.
20. Febriani A, Elya B, Jufri M. Uji akvitas dan keamanan hair tonic ekstrak daun kembang sepatu (Hibiscus rosa-sinensis) pada pertumbuhan rambut kelinci. J Farm Indones . 2016;8(1):259–69.
21. Autelitano A, Minassi A, Pagani A, Taglialatela-Scafati O, Appendino G. The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols. Acta Pharm Sin B. 2017;7(4):523–6.
22. Jusnita, N., and Syah, R.A., 2017, The formulation and physical stability test on ethanol extract of pare leaves shampoo, Indonesia Natural Research Pharmaceutical Journal, 2, 26-34.
23. Amin J, Simamora ELP, A E, Djajadisastra J. Green tea (Camellia sinensis, L.) ethanolic extract as hair tonic in nutraceutical: Physical stability, hair growth activity on rats, and safety test. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(5):94-99.
24. Lukman, A., Susanti, E., and Oktaviana, R., 2012, Gel formulation of cinnamon bark (Cinnamomum burmanii) oil as an anti-mosquito preparation, Indonesian pharmaceutical research journal, 1, 26-29.
25. Wasitaatmadja, S.M., Prakoeswa, C.R.S., Sukanto, H., dan Martodihardjo, S., 2014, Everything About Hair, Fakultas Kedokteran Universitas Indonesia, Depok, 59.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.
This licence applies to Author(s) and Public Reader means that the users mays :
- SHARE:
copy and redistribute the article in any medium or format - ADAPT:
remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication) - ALIKE:
If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original. - NO ADDITIONAL RESTRICTIONS:
You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
It does however mean that when you use it you must:
- ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
You may not:
- NONCOMMERCIAL: You may not use the article for commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.