Anti-inflammatory and Analgesic Effect of 70% Cinnamon Bark (Cinnamomum burmannii Blume.) Ethanolic Extract In Vivo

  • Rika Sari Dewi Department of Pharmacology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
  • Ni Made Dwi Sandhiutami Department of Pharmacology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
  • Beatrix Melani Evangelia Department of Pharmacology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
  • Muhammad Taher Bakhtiar Kuliyyah of Pharmacy, International Islamic University Malaysia, Malaysia

Abstract

Cinnamon bark is known as a medicinal plant to has anti-inflammatory and analgesic effects in vitro. This activity is due to bark of cinnamon containing several compounds including cinnamaldehyde, cinnamic alcohol, cinnamic acid and coumarin. The aim of this study was to observe anti-inflammatory and analgesic effects in vivo. Anti-inflammatory test using Winter method and rats. Rats were divided into five groups negative control (aquadest), positive control (sodium diclofenac), and three extract groups with different doses (300, 400, and 500 mg/kg BW). In an analgesic test using the Siegmund method and mice. Mice were also divided into five groups negative control (aquadest), positive control (sodium diclofenac), and three extract groups with different doses (300, 400, 500 mg/kg BW). Based on a statistical test, 70% ethanol extract of cinnamon bark has anti-inflammatory and analgesic effects, also showed that there was a significant difference between the positive controls and the three extract doses. This shows that the anti-inflammatory and analgesic activity of diclofenac sodium is better than the ethanol extract of cinnamon bark in reducing the edema volume of rats and the amount of mice stretch. In conclusion,cinnamon bark showed no significant increment in high doses of anti-inflammatory and analgesic.

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Published
2023-10-19
How to Cite
DEWI, Rika Sari et al. Anti-inflammatory and Analgesic Effect of 70% Cinnamon Bark (Cinnamomum burmannii Blume.) Ethanolic Extract In Vivo. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 2, p. 273-278, oct. 2023. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1374>. Date accessed: 25 may 2024. doi: https://doi.org/10.35814/jifi.v21i2.1374.
Section
Articles