Diabetic Wound Healing and Antimicrobial Activities of Gels Melastoma malabathricum L. and Psidium guajava L. in Sprague Dawley Rats

  • Refdanita Refdanita Department of Pharmaceutics, National Institute of Science and Technology, South Jakarta, 12640, Indonesia.
  • Tonny Cortis Maigoda Department of Nutrition, Poltekkes Kemenkes Bengkulu, Bengkulu, 38225, Indonesia.
  • Firdaus Firdaus Department of Nutrition, Public Health Faculty, Andalas University, Padang, Indonesia
  • Barakatun Nisak Department of Nutrition, Faculty of Medicine and Science, University Putra Malaysia, Serdang, Selangor, 43400, Malaysia
  • Teodhora Teodhora Department of Pharmaceutics, National Institute of Science and Technology, South Jakarta, 12640, Indonesia.


Diabetes mellitus (DM) is a degenerative disease characterized by abnormalities in carbohydrate, lipid, and protein metabolisms. This research was aimed at the gel’s pharmacological activity, the extract’s potential in treating diabetic wounds in male rats of Melastoma malabathricum L leaves (ML) and Psidium guajava L leaves (PL), as well as microbiological activity. Viscous extracts of ML and PL were prepared in gel dosage form with concentrations of 4% and 6%. Clindamycin was used as a positive control. This study was conducted using an experimental laboratory method, and the study population included white male rats. The pharmacological activity was tested in the form of a gel dosage formula, and the rats were made diabetic using alloxan. The potential of the extract was observed in healing diabetic wounds in male rats. ML and PL leaf extract gels affect wound healing in diabetic patients. This can be seen from the change in diameter. Wound swab examination revealed the presence of bacteria Klebsiella pneumoniae and Staphylococcus aureus. Secondary metabolites of flavonoids, tannins, steroids, and saponins help stimulate the regeneration of epithelial cells and tissues. The results for wound healing of 4% and 6% gel formulations were derived from maturation data on day 10.


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How to Cite
REFDANITA, Refdanita et al. Diabetic Wound Healing and Antimicrobial Activities of Gels Melastoma malabathricum L. and Psidium guajava L. in Sprague Dawley Rats. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 1, p. 97-106, apr. 2023. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1390>. Date accessed: 16 apr. 2024. doi: https://doi.org/10.35814/jifi.v21i1.1390.