Antioxidant and anti-elastase activity of Tampui (Baccaurea macrocarpa) and Ketapong (Terminalia badamia) barks and leaves

  • Lusiana Ariani Departement Pharmaceutical, Faculty of Pharmacy, Universitas Pancasila, 12640, Jakarta, Indonesia
  • Endah Wulandari Departement Phytochemistry, Faculty of Pharmacy, Universitas Pancasila, 12640, Jakarta, Indonesia
  • Yesi Desmiaty Departement Pharmaceutical, Faculty of Pharmacy, Universitas Pancasila, 12640, Jakarta, Indonesia
DOI: https://doi.org/10.35814/jifi.v22i2.1393

Abstract

Elastase is a protease that is involved in the breakdown of elastin in the dermis. Likewise, free radicals can cause elastin damage. Inhibition of elastase enzyme activity and scavenging of free radicals can prevent premature aging of the skin, especially wrinkles. The current study was to investigate the antioxidant and elastase inhibition properties of the leaves and bark of the Tampui (Baccaurea macrocarpa L.) and Ketapong (Terminalia badamia L.) plants, which may be employed as an anti-aging ingredient in cosmetics and nutraceuticals. B. macrocarpa and T. badamia's leaves and bark were extracted using reflux and 96% ethanol. Anti-elastase was examined using N-succ-(Ala)3-nitroanilide as a substrate, and the DPPH reagent was used to test the antioxidants' activity. Phytochemical screening indicated the presence of flavonoids, quinone, tannins, and steroids. Antioxidant activity of B. macrocarpa leaves (BML), B. macrocarpa bark (BMB), T. badamia leaves (TBL), and T. badamia bark (TBB) had IC50 values were 15.09±0.51; 22.89±1.51; 36.43±1.94; 39.23±1.76 ppm, respectively. The anti-elastase activity of  BML, BMB, TBL, and TBB had IC50 values were 48.86±2.29; 52.03±9.54; 44.42±4.53; 40.16±1.32 ppm, respectively. The ethanol extract of B. macrocarpa and T. badamia's leaves and bark exhibits anti-elastase and antioxidant action, proposing that it may be used as an anti-aging agent.

References

[1] G. D. Liyanaarachchi, J. K. R. R. Samarasekera, K. R. R. Mahanama, and K. D. P. Hemalal, “Tyrosinase, elastase, hyaluronidase, inhibitory and antioxidant activity of Sri Lankan medicinal plants for novel cosmeceuticals,” Ind Crops Prod, vol. 111, no. August 2017, pp. 597–605, 2018, doi: 10.1016/j.indcrop.2017.11.019.

[2] Y. Desmiaty, F. C. Saputri, M. Hanafi, R. Prastiwi, and B. Elya, “Anti-Elastase, Anti-Tyrosinase, And Anti-Oxidant of Rubus fraxinifolius Stem Methanolic Extract,” Pharmacognosy Journal, vol. 12, no. 2, pp. 271–275, 2020.

[3] A. I. Charles Dorni, A. Amalraj, S. Gopi, K. Varma, and S. N. Anjana, “Novel cosmeceuticals from plants—An industry guided review,” J Appl Res Med Aromat Plants, vol. 7, no. June 2016, pp. 1–26, 2017, doi: 10.1016/j.jarmap.2017.05.003.

[4] Z. N. Azwanida, O. E. Jonathan, and H. Melanie-Jaynes, “Antioxidant, anti-collagenase, anti-elastase and anti-tyrosinase activities of an aqueous cosmos caudatus kunth (Asteraceae) leaf extract,” Tropical Journal of Natural Product Research, vol. 4, no. 12, pp. 1124–1130, 2020, doi: 10.26538/TJNPR/V4I12.15.

[5] H. R. Rabbani, D. A. Purwanto, and I. Isnaeni, “Effect of Guava Powder Addition on Epigallocatechin Gallate (EGCG) Content of Green Tea and Its Antioxidant Activity,” Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, vol. 6, no. 2, p. 85, 2020, doi: 10.20473/jfiki.v6i22019.85-90.

[6] I. Binic, V. Lazarevic, M. Ljubenovic, J. Mojsa, and D. Sokolovic, “Skin ageing: Natural weapons and strategies,” Evidence-based Complementary and Alternative Medicine, vol. 2013, 2013, doi: 10.1155/2013/827248.

[7] A. Argyropoulou et al., “Natural compounds with anti-ageing activity.,” Nat Prod Rep, vol. 30, no. 11, pp. 1412–37, 2013, doi: 10.1039/c3np70031c.

[8] C. Veeresham, “Natural products derived from plants as a source of drugs.,” J Adv Pharm Technol Res, vol. 3, no. 4, pp. 200–1, Oct. 2012, doi: 10.4103/2231-4040.104709.

[9] P. K. Mukherjee, N. Maity, N. K. Nema, and B. K. Sarkar, “Bioactive compounds from natural resources against skin aging,” Phytomedicine, vol. 19, no. 1, pp. 64–73, 2011, doi: 10.1016/j.phymed.2011.10.003.

[10] R. Tundis, M. R. Loizzo, M. Bonesi, and F. Menichini, “Potential Role of Natural Compounds Against Skin Aging,” Curr Med Chem, vol. 22, no. 12, pp. 1515–1538, Mar. 2015, doi: 10.2174/0929867322666150227151809.

[11] C. C. Lin, Y. L. Chen, J. M. Lin, and T. Ujiie, “Evaluation of the antioxidant and hepatoprotective activity of terminalia catappa,” American Journal of Chinese Medicine, vol. 25, no. 2, pp. 153–161, 1997, doi: 10.1142/S0192415X97000172.

[12] H. M. Chiang et al., “Inhibitory effects of Terminalia catappa on UVB-induced photodamage in fibroblast cell line,” Evidence-based Complementary and Alternative Medicine, vol. 18, no. 1, pp. 1–9, 2018, doi: 10.1186/s12906-018-2308-4.

[13] Y. H. Huang, P. Y. Wu, K. C. Wen, C. Y. Lin, and H. M. Chiang, “Protective effects and mechanisms of Terminalia catappa L. methanolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblasts,” BMC Complement Altern Med, vol. 18, no. 1, pp. 1–9, 2018, doi: 10.1186/s12906-018-2308-4.

[14] M. Fadzelly, A. Bakar, N. E. Ahmad, F. A. Karim, and S. Saib, “Phytochemicals and antioxidative properties of Borneo indigenous liposu (Baccaurea lanceolata) and tampoi (Baccaurea macrocarpa) fruits,” Antioxidants, vol. 3, pp. 516–525, 2014, doi: 10.3390/antiox3030516.

[15] E. Erwin, W. Pusparohmana, I. Sari, … R. H.-, and undefined 2018, “Phytochemical and antioxidant activity evaluation of the bark of Tampoi (Baccaurea macrocarpa),” ncbi.nlm.nih.gov, Accessed: Dec. 09, 2021. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915813.1/

[16] J. A. E. Kraunsoe, T. D. W. Claridge, and G. Lowe, “Inhibition of Human Leukocyte and Porcine Pancreatic Elastase by Homologues of Bovine Pancreatic Trypsin Inhibitor †,” Biochemistry, vol. 2960, no. 95, pp. 9090–9096, 1996.

[17] R. Rungruang, W. Ratanathavorn, N. Boohuad, O. Selamassakul, and N. Kaisangsri, “Antioxidant and anti-aging enzyme activities of bioactive compounds isolated from selected Zingiberaceae plants,” Agriculture and Natural Resources, vol. 55, no. 1, pp. 153–160, Jan. 2021, doi: 10.34044/J.ANRES.2021.55.1.20.

[18] J. Wittenauer, S. Mäckle, D. Sußmann, U. Schweiggert-Weisz, and R. Carle, “Inhibitory effects of polyphenols from grape pomace extract on collagenase and elastase activity,” Fitoterapia, vol. 101, pp. 179–187, 2015, doi: 10.1016/j.fitote.2015.01.005.

[19] S. Pientaweeratch, V. Panapisal, and A. Tansirikongkol, “Antioxidant, anti-collagenase and anti-elastase activities of Phyllanthus emblica, Manilkara zapota and silymarin: an in vitro comparative study for anti-aging applications,” Pharm Biol, vol. 54, no. 9, pp. 1865–1872, 2016, doi: 10.3109/13880209.2015.1133658.
Published
2024-10-31
How to Cite
ARIANI, Lusiana; WULANDARI, Endah; DESMIATY, Yesi. Antioxidant and anti-elastase activity of Tampui (Baccaurea macrocarpa) and Ketapong (Terminalia badamia) barks and leaves. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 22, n. 2, p. 187-192, oct. 2024. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1393>. Date accessed: 03 dec. 2024. doi: https://doi.org/10.35814/jifi.v22i2.1393.
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