Antimetabolic Syndrome Effect of 70% Ethanol Leaves Extract Ficus carica Linn. in Streptozotocin-Induced and High-Fat Diet Rats

  • Rahmatul Qodriah Doctoral Program, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta 12640, Indonesia
  • Shirly Kumala Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta 12640, Indonesia
  • Syamsudin Syamsudin Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta 12640, Indonesia
  • Nancy Dewi Yuliana Department of Food Science and Technology, IPB University, Bogor, Indonesia; Halal Science Center, IPB University, Bogor, West Java, 16680, Indonesia
  • Vyacheslav Dushenkov International Research Training Center for Botanicals and Chronic Diseases (CBCD), Rutgers University, New Jersey, 08854, United States of America
  • Carrista Carrista Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta 12640, Indonesia


Diabetes and obesity are risk factors for metabolic syndrome. Fig (Ficus carica L.) one of the plants is well known in traditional medicine system for their medicinal and therapeutic potentials. Fig leaves contain flavonoid and triterpenoid compounds which have antimetabolic effect. Streptozotocin is used to make diabetogenic rats to produce hyperglycemia conditions in test animals and high-fat diet to make rats model obesity. This study aimed to test the antidiabetic and antiobesity effect of 70% ethanol extract of fig leaves based on the parameters of measuring blood glucose levels with glucometer and Cholesterol strips. In this
study, rats were divided into 6 groups, namely normal, negative, positive control, and 3 control groups at 70%
ethanol extract dose level (250, 500, and 600 mg/kgBW) per oral. The measurement results in normal, negative, and positive control dose of 250, 500, 600 mg/kgBW at blood glucose levels were 105.8, 192, 134.2, 161, 157.75, 145.2 mg/dL. The conclusion of the results obtained was that 70% ethanol extract of fig leaves with a dose of 600 mg/kgBW can have an antidiabetic and obesity effect by lowering blood glucose levels as measured using glucometer, cholesterol strips and decreased body weight rats.


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How to Cite
QODRIAH, Rahmatul et al. Antimetabolic Syndrome Effect of 70% Ethanol Leaves Extract Ficus carica Linn. in Streptozotocin-Induced and High-Fat Diet Rats. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 1, p. 153-158, apr. 2023. ISSN 2614-6495. Available at: <>. Date accessed: 24 feb. 2024. doi: