Penerapan Metode Nanopartikel Lipid Padat pada Masker Gel Peeloff Ekstrak Teripang Hitam (Holothuria atra) dan Uji Aktivitas Antioksidan

  • Deni Rahmat Departement of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta, 12640, Indonesia
  • Safira Nafisa Departement of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta, 12640, Indonesia
  • Catharina Maria Odilia Departement of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, DKI Jakarta, 12640, Indonesia
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Abstrak

Teripang Hitam (Holothuria atra) merupakan sumber potensial metabolit aktif seperti flavonoid yang banyak digunakan untuk produk nutrasetikal, farmasi, maupun kosmetik. Nanopartikel yang sering digunakan dalam produk kosmetik untuk kulit adalah Solid Lipid Nanoparticles (SLN). Pada penelitian ini akan dibuat SLN ekstrak teripang hitam dalam bentuk masker gel peel-off sebagai antioksidan. Teripang hitam diekstraksi menggunakan metode maserasi, sedangkan formulasi SLN menggunakan metode high shear homogenization dan freeze drying. Ekstrak dan SLN diformulasikan menjadi gel peel-off, kemudian dievaluasi meliputi organoleptik, homogenitas, viskositas, pH, daya sebar, waktu pengeringan, uji kekuatan tarikan, dan aktivitas antioksidan dengan metode DPPH. Nilai IC50 blanko (F1), gel peel-off ekstrak (F2), dan gel peel-off nanopartikel (F3) masing-masing sebesar 600,8727 ± 0,43; 580,7849±0,7; dan 592,76±0,55 µg/mL. Dapat disimpulkan metode SLN dapat diterapkan pada formulasi nanopartikel ekstrak teripang hitam namun masker gel peel-off dari ekstrak dan nanopartikel ekstrak memiliki aktivitas antioksidan yang sangat lemah.

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Diterbitkan
2023-04-30
##submission.howToCite##
RAHMAT, Deni; NAFISA, Safira; ODILIA, Catharina Maria. Penerapan Metode Nanopartikel Lipid Padat pada Masker Gel Peeloff Ekstrak Teripang Hitam (Holothuria atra) dan Uji Aktivitas Antioksidan. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 1, p. 131-137, apr. 2023. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1401>. Tanggal Akses: 05 sep. 2025 doi: https://doi.org/10.35814/jifi.v21i1.1401.
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Vol 21 No 1 (2023): JIFI
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