Optimization of Fast Disintegrating Tablets Diphenhydramine HCl using Co-process of Cross-link Yellow Kepok Banana Starch, Crospovidone, and Microcrystalline Cellulose

  • Tias Eka Rahmawati Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Banyumas, Central Java, 53182, Indonesia
  • Agus Siswanto Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Banyumas, Central Java, 53182, Indonesia
  • Asmiyenti Djaliasrin Djalil Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Banyumas, Central Java, 53182, Indonesia

Abstract

Diphenhydramine HCl is an antihistamine drug that is available in conventional tablet form. This study aimed to produce the optimum formula for a diphenhydramine fast disintegrating tablet (FDT) using a modification of starch, crospovidone, and microcrystalline cellulose (MCC) to produce quality tablets that meet the tablet's physical requirements and tablet dissolution. Starch modification was made using a two-step method of starch cross-link, then continued with silica coprecipitation. FDT was prepared by the direct compression method. Optimisation with the simplex lattice design (SLD) model uses three components: co-process starch crosslink-silica, crospovidone, and MCC, which obtained 14 formula designs. The hardness, wetting time, disintegration time, and percent dissolution are optimisation parameters. Equations, contour plots, and desirability values were determined as the optimum formula. Based on the research results, an optimum formula was obtained with the proportion of co-process cross-link starch-silica was 56.185 mg, crospovidone at 6 mg, and MCC at 45.815 mg. The result of hardness was 5 kg, wetting time 51.061 seconds, disintegration time 63.129 seconds, and dissolution was 100.972%. The interaction of the three components reduces hardness and increases disintegration time, wetting time, and percent dissolution.

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Published
2023-10-19
How to Cite
RAHMAWATI, Tias Eka; SISWANTO, Agus; DJALIL, Asmiyenti Djaliasrin. Optimization of Fast Disintegrating Tablets Diphenhydramine HCl using Co-process of Cross-link Yellow Kepok Banana Starch, Crospovidone, and Microcrystalline Cellulose. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 2, p. 231-238, oct. 2023. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1406>. Date accessed: 25 may 2024. doi: https://doi.org/10.35814/jifi.v21i2.1406.
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Articles