Encapsulation of Ketoprofen with Coacervation and Spray Drying Methods Using Pregelatinized Cassava Starch Phthalate as Film-Forming Excipient

  • YUDI SRIFIANA UNIVERSITAS INDONESIA
  • SILVIA SURINI UNIVERSITAS INDONESIA
  • ARRY YANUAR UNIVERSITAS INDONESIA

Abstract

This study was purposed to prepare microcapsules of ketoprofen by coacervation and spray drying methods and to characterize the resulting microcapsules. The microcapsules were prepared using pregelatinized cassava starch (PCS) and pregelatinized cassava starch phthalate (PCSPh) as a coating material. The obtained microcapsules were then characterized, including its recovery, shape and morphology, drug-loading efficiency, particle size distribution, swelling index, functional Groupanalysis, and drug release profile.The used PCSPh had a substitution degree of 0.0541 and soluble in basic aqueous medium. Microcapsules prepared by coacervation method had an irregular shape and  a hollow surface and the entrapment efficiency of 20.27% ± 1.82.Whereas, the spray dried microcapsules showed a nearly-spherical-shape with a biconcave surface and the entrapment efficiency was 80.22% ± 9.18. The release study results showed that within 8 hours ketoprofen released from the coacervation microcapsulesat pH 1.2 and pH 7.4 were 8% and 18%, respectively. In addition, ketoprofen released from spray-dried microcapsules within 8 hours at pH 1.2 and pH 7.4 were 5% and 25%, respectively. In conclusion, the microcapsules prepared by both methods could extent the drug released, thus it could be possible to be used for a sustained release device.

References

1. Benita S. Microencapsulation, methods and industrial application. New York: Marcel Dekker; 1996. 1-18.
2. Bansode SS, Banarjee SK, Gaikwad DD, Jadhav SL, and Thorat RM. Microencapsulation: A Review. International Journal of Pharmaceutical Sciences Review and Research. 2010.1(2).38-43.
3. Wilmana PF. Farmakologi dan Terapi. Edisi 4. Jakarta: Bagian Farmakologi Fakultas Kedokteran UI; 1995. 218.
4. Bule MV, Singhal RS, Kennedy JF. Microencapsulation of Ubiquinone-10 in Carbohydrate Matrices for Improve Stability. Carbohydrate Polymers. 2010.82(4).1290-6.
5. Gallant DJ. Electron Microscopy of Starch and Starch Products. In: Radley JA, editor. Examination and Analysis of Starch and Starch Products. London: Applied Science Publisher Ltd; 1976.
6. Liu P, Yu L, Liu H, Chen L, Li L. Glass transition temperature of starch studied by a high-speed DSC. Carbohydrate Polymers. 2009.77(2).250-3.
7. Tewes F, Frank B, Jean-Pierre B. Biodegradable microspheres: Advances in production technology. In: Benita S. Microencapsulation methods and industrial applications. 2nd Ed. New York: Taylor & Francis Group, CRC Press; 2006. 1-41.
8. Dastidar TG, Netravali AN. ‘Green’ crosslinking of native starches with malonic acid and their properties. Carbohydrate Polymer. 2012.90(4).1620-8.
9. Oliveira BF, Santana MHA, and Re MI. Spray- dried chitosan microspheres cross-linked with D,L- gyceraldehyde as a potential drug delivery system: Preparation and characterization. Braz. J. Chem. Eng. 2005.22(3):353-60.
How to Cite
SRIFIANA, YUDI; SURINI, SILVIA; YANUAR, ARRY. Encapsulation of Ketoprofen with Coacervation and Spray Drying Methods Using Pregelatinized Cassava Starch Phthalate as Film-Forming Excipient. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 12, n. 2, p. 162-169, sep. 2014. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/141>. Date accessed: 24 nov. 2024.
Section
Articles