Formulation of Mucoadhesive Tablets of Ethanolic Extract Mango’s Leaves Variety Bapang (Mangifera indica L. ‘Bapang’) as Antidiabetic Using Guar Gum Matrix

  • LIA NADIA FITHRIYANI UNIVERSITAS JENDERAL SOEDIRMAN
  • DHADHANG WAHYU K UNIVERSITAS JENDERAL SOEDIRMAN
  • EKA PRASASTI NUR R UNIVERSITAS JENDERAL SOEDIRMAN

Abstract

Ethanolic extract of mango’s leaves variety of bapang (Mangifera indica L. ‘Bapang’) has been known to contains mangiferin which has antidiabetic activity in patients with diabetes mellitus. This study aimed to obtain a formulation of tablets of ethanolic extract mango leaves with variety of bapang with good physical characteristic and know the effect of variations concentration of guar gum on the properties of mucoadhesive. Tablets were prepared using wet granulation method varying levels of guar gum as a bioadhesive matrix. Tablets were tested physical characteristics and mucoadhesive strength in vitro by using a rotating cylinder and observed within 8 hours. The results showed that the tablets of ethanolic extract mango leaves with variety of bapang have good physical characteristics. The result of mucoadhesive in vitro test showed that all formulas have good mucoadhesive strength. Mucoadhesive strength increased with the increase in the concentration of guar gum. The result of this research showed that the tablets of formula 4 with the highest concentration of guar gum showed the best mucoadhesive strength where they could be attach of 7 ± 1 hour.

References

1. Mathalaimutoo A. Aktivitas antidiabetes ekstrak etanol daun mangga bapang (Mangifera indica L. var. bapang) pada tikus galur Wistar yang diinduksi aloksan [abstract]. eJurnal Mahasiswa Universitas Padjadjaran. 2012.1(1).
2. Basha DP, Kumar KP, Teja BB, Subbarao M. Antidiabetic activity on extracts of Mangifera indica
in alloxan monohydrate induced diabetic rats. Drug Invention Today. 2011.3(7):165-8.
3. Winantari AN, Hendradi E, Widjaja B. Daya mukoadhesi dan pelepasan obat in vitro tablet vaginal mukoadhesif metronidazol menggunakan polimer Carbopol 940. Artocarpus. 2008.8(2):91-8.
4. Carvalho FC, Bruschi ML, Evangelista RC, Gremiao MPD. Mucoadhesive drug delivery systems. Brazilian Journal of Pharmaceutical Sciences. 2010.46(1):1-17.
5. Agoes G. Pengembangan sediaan farmasi. Bandung: Institut Teknologi Bandung Press; 2006.
6. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Trop J Phar Res. 2008.7:1055-66.
7. Jain S, Yadav SK, Patil UK. Preparation and evaluation of sustained release matrix tablet of furosemide using natural polymers. Research J Pharm and Tech. 2008.1(4):374-6.
8. Waheed A, Miana GA, Ahmad SI. Clinical investigation of hypoglycemic effect of leaves of Mangifera indica in type-2 (NIDDM) diabetes mellitus. Pakistan Journal of Pharmacology. 2006.23:13-8.
9. Lachman L, Lieberman HA, Kanig JL. Teori dan praktek farmasi industri, Edisi III. Jilid 2. Diterjemahkan oleh Siti Suryatmi. Jakarta: Penerbit Universitas Indonesia; 1994.
10. Lieberman HA, Martin MR, Gillbert SB. Pharmaceutical dosage forms, Disperse system. Vol. 3. Informa Health Care; 1989.
11. Siregar CJP, Wikarsa S. Teknologi farmasi sediaan tablet: Dasar-dasar praktis. Jakarta: Penerbit Buku Kedokteran EGC; 2010.
12. Depkes RI. Farmakope Indonesia. Edisi III. Jakarta: Departemen Kesehatan Indonesia; 1979.
13. Bernkop SA. Mucoadhesive polymers in polymeric biomaterial. Severian Dumitriu (Editor). New York: Marcell Dekker Inc; 2002.
14. Mardiah E. Penentuan aktivitas dan inhibisi enzim polifenol oksidase dari apel (Pyrus matus Linn.). Jurnal Kimia Andalas. 1996.2(2):22-7.
15. Sellamuthu PS, Muniappan BS, Perumal SM, Kandasamy M. Antihyperglycemic effect of mangiferin in streptozotocin induced diabetic rats. Journal of Health Science. 2009.55:206-14.
16. Voight R. Pelajaran Teknologi Farmasi. Diterjemahkan oleh Soendani Noerono Soewandhi. Edisi ke-5. Cetakan kedua. Yogyakarta: Universitas Gadjah Mada Press; 1995.
17. Banker GS, Anderson NR. Tablet. Dalam: Lachman L, Liebermen HA, Kanig JL. Tablet In the theory and practice of industrial pharmacy. 3rd Ed. Diterjemahkan oleh Siti Suryatmi. Jakarta: Penerbit Universitas Indonesia; 1994.
18. Varshosaz J, Tavakoli N, Kheirolahi F. Use hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride. AAPS Pharm Sci Tech. 2006.7(1):1-7.
19. Mythri G, Kavitha K, Kumar MR, Singh SJ. Novel mucoadhesive polymer-A review. Jurnal of Applied Pharmaceutical Science. 2011.1(8):37-42.
20. Majithiya RJ, Raval AJ, Umrethia ML, Ghosh PK, Murthy RSR. Enhancement of mucoadhesion by blending anion, cation, & nonionic polymers. Drug Delivery Technology. 2008.8(2):40-5.
21. Sreenivas SA, Pai KV. Thiolated chitosans: Novel polymers for mukoadhesive drug delivery-A review. Tropical Journal of Pharmaceutical Research. 2008.7(3):1077-88.
22. Petrucci RH. Kimia dasar prinsip dan terapan modern. Edisi IV. Jilid 2. Diterjemahkan oleh Suminar Achmadi. Jakarta: Penerbit Erlangga; 1985.
Published
2014-09-30
How to Cite
FITHRIYANI, LIA NADIA; K, DHADHANG WAHYU; R, EKA PRASASTI NUR. Formulation of Mucoadhesive Tablets of Ethanolic Extract Mango’s Leaves Variety Bapang (Mangifera indica L. ‘Bapang’) as Antidiabetic Using Guar Gum Matrix. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 12, n. 2, p. 176-182, sep. 2014. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/144>. Date accessed: 22 dec. 2024.
Citation Formats
Issue
Vol 12 No 2 (2014): JIFI
Section
Articles
License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.