Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

  • I Gusti Agung Ayu Kartika Yoga and Health Study Program, Faculty of Brahma Widya, Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar, North Denpasar, Bali 80237, Indonesia
  • Suryani Suryani Pharmacology and Toxicology Department, Faculty of Pharmacy, Universitas Jendral Achmad Yani, Cimahi, West Java 40531, Indonesia
  • Dwi Hadi Setya Palupi College of Pharmacy, Yayasan Pharmasi Semarang, Central Java 50196, Indonesia
  • I Ketut Adnyana Pharmacology and Clinical Pharmacy Department, School of Pharmacy, Institut Teknologi Bandung, West Java 40132, Indonesia


Sirih bumi (Peperomia pellucida [L.] Kunth.) is a medicinal herb. Anti-inflammatory activities are reported. These plant extracts have been shown to reduce inflammation in many studies, but it is unknown which extract works best. The objectives if this study were determine the extract that has the best anti-inflammatory activity from sirih bumi. The activity was assessed from the impact of stabilising red blood cell membranes in vitro. The research was then continued with a literature study on the chemical compounds containing the best extracts. To determine the prediction of the compound responsible for its activity and potency, several in silico tests were carried out, such as PASS online, Pre-ADMET online, and Protox II. The test results showed that the ethyl acetate extract at 200 g/mL concentration showed similar activity to aspirin at the same concentration. The activity of this extract increased with increasing concentration of the extract. Six compounds were reported to be isolated from this type of extract. Dillapiol and its derivative 6-allyl-5-methoxy-1,3-benzodioxol-4-ol are predicted to be compounds that have anti-inflammatory effects by inhibiting the membrane permeability mechanism of ethyl acetate extract. Ethyl acetate extract showed the best anti-inflammatory activity among the other type of extract from sirih bumi. Ethyl acetate extract is a type of extract with the best anti-inflammatory activity from sirih bumi.


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How to Cite
AYU KARTIKA, I Gusti Agung et al. Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 2, p. 215-222, oct. 2023. ISSN 2614-6495. Available at: <>. Date accessed: 25 may 2024. doi: