Evaluation of Antibiotic Use with Quantitative Methods in Hospitalization Pneumonia Patients at West Nusa Tenggara Hospital

  • Sondang Khairani Doctoral Program, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta, 12640, Indonesia
  • Hesty Utami Ramadaniati Departement of Pharmacy Clinis Community, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta, 12640, Indonesia
  • Prih Sarnianto Departement of Pharmacy Clinis Community, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta, 12640, Indonesia
  • Erna Kristin Faculty of Medicine Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia
  • Yusi Anggriani Department of Pharmacy Clinic Community, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta, 12640, Indonesia
DOI: https://doi.org/10.35814/jifi.v21i2.1449

Abstract

Abstract


Overuse of antibiotics is a public health challenge that can lead to antimicrobial resistance. To reduce the occurrence of antibiotic resistance, it is necessary to evaluate the use of antibiotics to determine the rational use of drugs using quantitative methods, namely the ATC /DD method. The purpose of the study was to determine the use of antibiotics and describe the pattern of antibiotic use in inpatients at West Nusa Tenggara Hospital using the ATC /DD method and DU90%. The research method is a cross-sectional study design with retrospective data collection on adult pneumonia patients hospitalized in the period Januari-December  2019 and 2022, data obtained from medical records. The results of the study met the inclusion criteria of 218 patients with the majority being male 117 (53.67%) and the most age > 65, namely 66 (30.28%). Antibiotic use has a total DDD value of 185.56 DDD/100 days of care with the highest antibiotic DDD value being ceftriaxone which is 104.00 DDD/100 days of hospitalization while antibiotics that are included in the DU 90% are ceftriaxone, levofloxacin, cefoperazon and meropenem. Conclusion the most antibiotics used were ceftriaxone 104.00 DDD/100 days of length of stay.

References

1. PDPI. Indonesian Lung Doctors Association (PDPI) Outbreak Pedoman Pneumonia di Tiongkok. 2020.

2. Bramantono B, Rachman BE, Marfiani E, Kurniati ND, Arifijanto MV, Jearanaiwitayakul T. The Bacterial Pneumonia Characteristics based on Climate and Meteorological Parameters in Indonesia, the Tropical Country: A Preliminary Study. Biomol Heal Sci J [Internet]. 2021 Jun 30 [cited 2022 Jan 4];4(1):15–21. Available from: https://www.e-journal.unair.ac.id/BHSJ/article/view/26926.

3. Ministry of Health Republic Indonesia. Basic Health Research 2018. Jakarta; 2018.

4. Wells BG, DiPiro JT, Schwinghammer TL, Cecily V. DiPiro. Pharmacotherapy Handbook Ninth Edition. New
York; 2015.

5. Katzung BG, Vanderah TW. Basic & clinical pharmacology. 15th ed. New York McGraw-Hill; 2018.

6. World Health Organization. Guidelines for ATC classification and DDD assignment 2013. In 2013 [cited 2021 Aug 8]. Available from: www.whocc.no

7. World Health Organization. WHO releases the 2019 AWaRe Classification Antibiotics [Internet]. [cited 2021 Aug 8]. Available from: https://www.who.int/news/item/01-10-2019-who-releases-the-2019-aware-classification-antibiotics

8. Hanifah S, Melyani I, Madalena L. Evaluation Of Antibiotic Use Using The Atc/Ddd And Du90% Method In Inpatient Patients In The Internal Disease Medical Staff Group In One Of The Private Hospitals In The City Of Bandung. Farmaka [Internet]. 2022;20(1):21–6. Available from: https://jurnal.unpad.ac.id/farmaka/article/view/34724

9. Sari A, Safitri I. Study On The Use Of Antibiotics In Childhood Pneumonia Patients In A Hospital Pku Muhammadiyah Yogyakarta Using The Defined Daily Dose (DDD) Method.. J Ilm Ibnu Sina [Internet]. 2016 Oct 5
[cited 2023 Aug 14];1(2):151–62. Available from: https://e-jurnal.stikes-isfi.ac.id/index.php/JIIS/article/view/38

10. Shallcross LJ, Howard SJ, Fowler T, Davies SC. Tackling the threat of antimicrobial resistance: from policy to sustainable action. Philos Trans R Soc B Biol Sci [Internet]. 2015 Jun 6 [cited 2023 Aug 14];370(1670). Available from: /pmc/articles/PMC4424432/

11. Organization WH. Global action plan on antimicrobial resistance. World Heal Organ. 2017;1–28.

12. Dyar OJ, Huttner B, Schouten J, Pulcini C. What is antimicrobial stewardship? Clin Microbiol Infect [Internet].
2017 [cited 2023 Aug 14];23:793. Available from: http://dx.doi.org/10.1016/j.cmi.2017.08.026

13. Gallagher JC, Justo JA, Chahine EB, Brandon Bookstaver P, Scheetz M, Suda KJ, et al. Preventing the Post-Antibiotic Era by Training Future Pharmacists as Antimicrobial Stewards. American Journal of Pharmaceutical Education. 2018;82(6):627-634.

14. Wang H, Wang H, Yu X, Zhou H, Li B, Chen G, et al. Impact of antimicrobial stewardship managed by clinical pharmacists on antibiotic use and drug resistance in a: Chinese hospital. 2010-2016: a retrospective observational study. BMJ. 2019;9(8):1-9. [cited 2023 Aug 14]; Available from: http://bmjopen.bmj.com/

15. Mboi N, Murty Surbakti I, Trihandini I, Elyazar I, Houston Smith K, Bahjuri Ali P, et al. On the road to universal health care in Indonesia, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet [Internet]. 2018;392(10147):581–91. Available from: http://dx.doi.org/10.1016/S0140-6736(18)30595-6

16. Limato R, Nelwan EJ, Mudia M, de Brabander J, Guterres H, Enty E, et al. A multicentre point prevalence survey of patterns and quality of antibiotic prescribing in Indonesian hospitals. JAC-antimicrobial Resist. 2021;3(2):1-10.

17. Ministry of Health Republic Indonesia. Technical Instructions for Evaluation of Drug Use in Health Facilities.
2017;1–50.

18. Khairani S, Nasif H, Muchtar H. Evaluation of Switch Therapy Antibiotics in Pneumonia Patients at RSUP Dr. M. Djamil Padang. Jurnal Penelitian Farmasi Indonesia. 2013; 39-48

19. Torres A, Cilloniz C, Niederman MS, Menéndez RC, D J, Wunderink RG, et al. Pneumonia. Nat Rev. 2021;7(25).1-28

20. WHO. World Health Organizatition. Pneumonia [Internet]. WHO. 2016 [cited 2022 Mei 8]. Available from: http://www.who.int/mediacentre/factsheets/fs331/en/.

21. PDPI. P ndonesian Lung Doctors Association (PDPI). Pneumonia Community : Guidelines for Diagnosis and Management in Indonesia.2014

22. Central Statistical Agency. Percentage of Population Who Have Health Insurance by Province and Type of Insurance. [Internet]. Jakarta; 2021. Available from: https://www.bps.go.id/indikator/indikator/view_data_pub/0000/api_pub/UUROM3lMeGsxZ0czT2xFeEJsK0VWZz09/da_04/1

23. Kresnawati V, Herawati F, Crisdiono H, Yulia R. Analysis of Antibiotic Use in Community Pneumonia Patients at Kediri District Hospital. MPI (Media Pharm Indonesiana. 2021;3(4). 245-252. [cited 2023 Jun 5];3(4):245–52. Available from: https://journal.ubaya.ac.id/index.php/MPI/article/view/4468

24. Torres A, Peetermans WE, Giovanni Viegi A, Blasi5 F. Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax [Internet]. 2013;68(11):1057–65. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812874/

25. Sitompul PA, Roza I, Siti M, Rusli A, Sundari T, Marlina R, et al. Length of stay of pneumonia patients associated with comorbid and complications factors in referral National Infectious Diseases Hospital. Tanzan J Health Res. 2023;24(1). 1-5.

26. Nisak NA, Yulia R, Hartono R, Herawati F. Evaluation of the Use of Antibiotics in Contaminated Clean Surgery Patients at Bhayangkara Hospital, Surabaya. J Pharmascience. 2022;9(1):1-10

27. Medscape. Merrem IV (meropenem) dosing, indications, interactions, adverse effects, and more [Internet].
[cited 2023 Jul 21]. Available from: https://reference.medscape.com/drug/merrem-iv-meropenem-342565

28. World Health Organization. Guidelines for ATC Classification and DDD Assignment. In Oslo, Norway; 2021. Available from: https://www.whocc.no/filearchive/publications/2021_guidelines_web.pdf

29. Yulia R, Mariza JW, Soedarsono, Herawati F. Bacterial profile and antibiotic use in pneumonia patients at Dr. Soetomo General Hospital. Curr Respir Med Rev [Internet]. 2020 Feb 17 [cited 2023 Jul 6];16(1):21–7. Available from: https://scholar.unair.ac.id/en/publications/bacterial-profile-and-antibiotic-use-in-pneumonia-patients-at-dr-

30. Nuzulul. Quantity of Antibiotic Use in Wards and Obstetrics at DR Kariadi Hospital after the PP-PPRA Campaign.

31. WHO. WHO Collaborating Centre for Drugs Statistic Methodology [Internet]. [cited 2023 Jul 21]. Available from: https://www.whocc.no/

32. Mahmudah F, Sumiwi SA, Hartini S. Study of Antibiotic Use Based on ATC/DDD and DU 90% in the Digestive Surgery Department at One Hospital in Bandung Indones J Clin Pharm [Internet]. 2016 Oct 5 [cited 2023 Jul 21];5(4):293–8. Available from: https://jurnal.unpad.ac.id/ijcp/article/view/1376.

33. Pani S, Barliana MI, Halimah E, Pradipta IS, Annisa N. Monitoring Antibiotic Use Using ATC/DDD and DU 90% Methods: Observational Study in All Community Health Centers in North Gorontalo Regency. Indones J Clin Pharm [Internet]. 2015 Dec 1 [cited 2023 Jul 21];4(4):275–80. Available from: https://jurnal.unpad.ac.id/ijcp/article/view/12982

34. Hasrianna H, Annisa N, Milanda T, Pradipta IS, Abdulah R. Monitoring Antibiotic Use with ATC/DDD and DU90% Methods at Hospital Abepura Jayapura, Indonesia Indones J Clin Pharm [Internet]. 2015 Sep 2 [cited 2023 Jul 21];4(3):218–25. Available from: http://jurnal.unpad.ac.id/ijcp/article/view/12974

35. Ministry of Health Republic Indonesia. Rational Drug Use Module 2011. Modul Pengguna Obat Rasional. 2011;3–4.
Published
2023-10-19
How to Cite
KHAIRANI, Sondang et al. Evaluation of Antibiotic Use with Quantitative Methods in Hospitalization Pneumonia Patients at West Nusa Tenggara Hospital. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 2, p. 303 - 310, oct. 2023. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1449>. Date accessed: 27 apr. 2024. doi: https://doi.org/10.35814/jifi.v21i2.1449.
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Vol 21 No 2 (2023): JIFI
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