Cost Effectiveness Analysis in Scientific Herbal Therapy Compared to Conventional Therapy for Dyspepsia

  • Inta Nurhaliza Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, Central Java, 53180, Indonesia
  • Galar Sigit Prasuma Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, Central Java, 53180, Indonesia
  • Ergia Andang Sugiantoro UPTD Wisata Kesehatan Jamu, Kalibakung, Tegal, Central Java, 52565 Indonesia
  • Lianawati Lianawati Center for Health Economic Studies, Universitas Muhammadiyah Purwokerto, Purwokerto, Central Java, 53180, Indonesia
  • Praewthip Sutheeraprasert Faculty of Nursing, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, 34000, Thailand
  • Didik Setiawan Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, Central Java, 53180, Indonesia
DOI: https://doi.org/10.35814/jifi.v21i2.1470

Abstract

Dyspepsia is a common digestive disorder among global health problems. This study aimed to examine the cost-effectiveness of scientific herbs in the treatment of dyspepsia. This study has used a societal perspective, but the indirect costs are considered equal because the patient is undergoing outpatient care. The analysis was used to determine the cost-effectiveness using the Incremental Cost-Effectiveness Ratio (ICER) method. The results were reported in rupiah currency, which includes categories of direct medical costs and direct non-medical costs. Sensitivity analysis reported changes in results, taking into account various possible influencing variables. A total of 62 patients who were respondents in this study were included in scientific herbal therapy (48.38%) and conventional dyspepsia therapy (51.62%). The cost of scientific herbal therapy was higher than conventional dyspepsia therapy (45.558±4.351 vs. 39.202±4.500). However, this difference was not statistically significant on the effectiveness of therapy (96.67% vs. 90.62%; p-value 0.600), the utility index of scientific herbal medicine was greater than conventional dyspepsia therapy (0.85±0.11 vs. 0.74±0.14). The ICER value for 1 additional unit of effectiveness was IDR 105,933; while for the addition of 1 unit of quality of life was IDR 57,781. The effectiveness of scientific herbal medicine therapy for dyspepsia was greater than the effectiveness of conventional dyspepsia therapy, where the cost was higher but the effectiveness was better.

References

1. Schellack N, Schellack G, Van Der Sandt N, Masuku B. Gastric pain. SA Pharm J. 2017;84(2):28–35.

2. Huang I, Pranata R, Pangestu W, Kosasih FN, Raffaello WM, Yanto TA, et al. The prevalence of uninvestigated dyspepsia and the association of physical exercise with quality of life of uninvestigated dyspepsia patients in Indonesia: An internet-based survey. Indian J Gastroenterol. 2021;40(2):176–82.

3. Faridah U, Hartinah D, Farida N. Relationship of diet with frequency of recurrence of dyspepsia in Puskesmas Pamotan Rembang Regency. 14th Univ Res Colloqium. 2021;495-501.

4. Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T, Suzuki H, Tominaga K, Nakada K, Nagahara A, Futagami S. Evidence-based clinical practice guide¬lines for functional dyspepsia. Journal of gastroenterology. 2015;50(2):125-39.

5. Triyono A, Astana PW, T.I. SP. Clinical observation of the effect of jamu dyspepsia formula on liver function. J Trop Pharm Chem. 2016;3(11):246–50.

6. Directorate General of Pharmaceutical and Medical Devices, 2017. In: Pharmacopoeias Formularies Herbal Medicine. II. ed. Ministry of Health.

7. Republic Indonesia, Jakarta.Thavorn K, Mamdani MM, Straus SE. Efficacy of turmeric in the treatment of digestive disorders: a systematic review and meta-analysis protocol. Systematic reviews. 2014;3:1-6.

8. Gwee KA, Holtmann G, Tack J, Suzuki H, Liu J, Xiao Y, Chen MH, Hou X, Wu DC, Toh C, Lu F. Herbal medicines in functional dyspepsia—Untapped opportunities not without risks. Neurogastroenterology & Motility. 2021;33(2):e14044.

9. Talley NJ, Vakil N. Practice parameters Committee of the American ollege of Gastroenterology. Guidelines for the management of dyspepsia. Official journal of the American College of Gastroenterology| ACG. 2005;100(10):2324-37.

10. Talley NJ, Locke GR, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, Rojavin MA, Tack J. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut. 2006;55(7):933-9.

11. Lorena SLS, Tinois E, Brunetto SQ, Camargo EE, Mesquita MA. Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: influence of gender and anxiety. J Clin Gastroenterol. 2004;38(3):230–6.

12. Herman H, Lau SHA. Risk factors for dyspepsia. J Ilm Kesehat Sandi Husada. 2020;12(2):1094–100.

13. Ratnadewi NK, Jaya Lesmana CB. The relationship between coping strategies and functional dyspepsia in patients at the internal medicine clinic at Wangaya Regional General Hospital, Denpasar. Medicina (B Aires). 2018;49(2):257–62.

14. Lestari TW, Prihatini N, Delima. Gambaran kualitas hidup pasien dengan keluhan dispepsia yang diberi perawatan dengan jamu (Data Registri Jamu ). J Penelit dan Pengemb Pelayanan Kesehat. 2020;4(2):15-22.

15. Muya Y, Murni AW, Herman RB. Karakteristik penderita dispepsia fungsional yang mengalami kekambuhan di Bagian Ilmu Penyakit Dalam RSUP Dr. M. Djamil Padang, Sumatera Barat Tahun 2011. J Kesehat Andalas. 2015;4(2):490–6.

16. Karyanah Y. Analisis faktor-faktor yang mempengaruhi kejadian dispepsia fungsional pada mahasiswa Program Studi Keperawatan Fakultas Ilmu-Ilmu Kesehatan Universitas Esa Unggul. Int J Otolaryngol Head Neck Surg. 2018;3(2):72-8.

17. Octaviana ESL. Faktor-faktor yang berhubungan dengan upaya keluarga dalam pencegahan penyakit dispepsia di wilayah kerja Puskesmas Mangkatip Kabupaten Barito Selatan. J Langsat. 2018;5(1):1-4.

18. Bordbar G, Miri MB, Omidi M, Shoja S, Akhavan M. Comparison of a novel herbal medicine and omeprazole in the treatment of functional dyspepsia: A randomized double-blinded clinical trial. Gastroenterol Res Pract. 2020;2020:1-9.

19. Diana S, Nurman M. Pengaruh konsumsi perasan air kunyit terhadap rasa nyeri pada penderita gastritis akut usia 45-54 tahun di Desa Kampung Pinang Wilayah Kerja Puskesmas Perhentian Raja. J Ners. 2020;4(2):130–8.

20. Elliya R, Setiawati, Sari RP. Pemberian air kunyit terhadap nyeri akut dispepsia pada lansia di Dusun 07 Mutun Kabupaten Pesawaran. J Kreat Pengabdi Kpd Masy. 2022;5:3649–62.

21. Ho L, Zhong CCW, Wong CHL, Wu JCY, Chan KKH, Wu IXY, et al. Chinese herbal medicine for functional dyspepsia: a network meta-analysis of prokinetic-controlled randomised trials. Chinese Med (United Kingdom). 2021;16(1):1-29.

22. Kristiana L, Maryani H, Lestari W. Gambaran pelak¬sanaan pelayanan kesehatan tradisional ramuan menggunakan jamu tersaintifikasi (studi kasus di BKTM Makassar dan Puskesmas A Karanganyar). Media Penelit dan Pengemb Kesehat. 2017;27(3):185–96.

23. Graham DY, Tansel A. Interchangeable use of proton pump inhibitors based on relative potency. Clin Gas¬troenterol Hepatol. 2018;16(6):800-8.

24. Shetty AJ, Balaraju G, Shetty S, Pai CG. Quality of life in dyspepsia and its subgroups using EQ-5D (EuroQol) questionnaire. Saudi J Gastroenterol. 2017;23(2):112–6.

25. Angelia J, Susanto H. Hubungan kecemasan dengan derajat keparahan dispepsia pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara angkatan 2014. Tarumanagara Med J. 2019;1(3):554-50.

26. Ikakusumawati ND, Magistasari D, Yuhara NA, Andayani TM, Supanji S, Kristina SA. Gambaran kualitas hidup pada pasien diabetik retinopati berdasarkan tingkat keparahan Visus. Journal Manag Pharm Pract. 2020;10(2):105-17.

27. Permatasari L. Faktor risiko, klasifikasi, dan ter¬api sindrom dispepsia. Cermin Dunia Kedokt. 2017;44(12):870–3.

28. Febriyanti RM, Maesaroh I, Supriyatna S, Sukandar H, Maelaningsih FS. Pharmacoeconomics analysis of scientification of antihypertensive, antihyperglycemic, antihpercholesterolemic, and antihyperuricemic jamu. Indones J Pharm Sci Technol. 2014;1(2):129-38.

29. Hidayah L, Ayu Nuning Farida Afiatna F. Analisis kesediaan membayar willingness to pay (WTP) konsumen terhadap produk batik tulis khas jombang. J Penelit Bid Inov Pengelolaan Ind. 2021;1(01):42–50.

30. teigenberger C, Flatscher-Thoeni M, Siebert U, Leiter AM. Determinants of willingness to pay for health services: a systematic review of contingent valuation studies. Eur J Heal Econ. 2022;23(9):1455–82.
Published
2023-10-16
How to Cite
NURHALIZA, Inta et al. Cost Effectiveness Analysis in Scientific Herbal Therapy Compared to Conventional Therapy for Dyspepsia. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 2, p. 201-208, oct. 2023. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1470>. Date accessed: 24 nov. 2024. doi: https://doi.org/10.35814/jifi.v21i2.1470.
Citation Formats
Issue
Vol 21 No 2 (2023): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.