The effectiveness of butterfly pea hydrogel film (Clitoria ternatea) with chitosan and poly-vinyl-alcohol based as diabetic wound healing
Abstract
Butterfly Pea possesses anti-oxidant activities with IC50 470 μg/ml of wound healing acceleration quality. Hydrogel for diabetic wound healing due to its physical characteristic that binds water, aside from its qualities that wets the surface and bio-compatibility in the body. This study aimed to identify Effectivity Test of Hydrogel Film Preparation with Butterfly Pea (Clitoria ternatea L.) Water Extract for Diabetic Wound Healing, employing True Experimental method which involves 12 rats divided into 4 groups. The control group was treated without the Hydrogel (HET) or HET0 on hyperglycemic rats, HET1 (2%), HET2 (5%), and HET3 (7,5%). The findings revealed wounds treated with HET0 was healed in 9 days with 11.13 mm of diameter (100%), HET1 was healed in 6 days with 15.22 mm of diameter (100%), HET2 that was healed in 4 days with 11.29 mm of diameter (100%), and HET3 that was healed in 8 days with 9.05 mm of diameter (100%). It was concluded that the effectivity test revealed that the best formula is HET2 (5%) healed in 4 days with 11.29 mm of diameter in 100%.
References
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[2] A. E. Al-Snafi, “Pharmacological Importance of Clitoria Ternatea – A Review Pharmacological Importance Of Clitoria Ternatea – A Review,” Iosr J. Pharm., vol. 6, no. 3, pp. 68–83., 2016.
[3] M. B. Lijon, N. S. Meghla, E. Jahedi, M. A. Rahman, and I. Hossain, “Phytochemistry and Pharmacological Activities of Clitoria ternatea,” Int. J. Nat. Soc. Sci., vol. 4, no. 1, pp. 1–10, 2017.
[4] A. M. Marpaung, “Tinjauan Manfaat Bunga Telang ( Clitoria ternatea L .) Bagi Kesehatan Manusia,” J. Funct. food Nutraceutical, vol. 1, no. 2, pp. 1–23, 2020, doi: 10.33555/jffn.v1i2.30.
[5] Y. Harliatika, “Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilariamalacensis lamk.) Dengan Kombinasi Basis Karbopol 940 dan Hpmc,” J. Pharm. Sci., vol. 6, no. 1, 2021.
[6] E. Marin, Rojas, and Ciro, “A Review Of Pva Derivatives: Promising Materials of Pharmaceutical and Biomedical Applications,” African J. Pharm. Pharmacol., vol. 8, no. 24, 2014.
[7] U. K. Parida, A. K. Nayak, and Binhani, “Synthesis and Characterization of Chitosanpolyvinyl Alcohol Blended With Cloisite 30b For Controlled Release of The Anticancer Drug Curcumin,” J. Biomater. Nanobiotechnology, vol. 2, pp. 414–425, 2011.
[8] A. Marpaung, N. Andarwulan, P. Hariyadi, and D. N. Faridah, “The Wide Variation of Color Stability of Butterfly Pea (Clitoria ternatea L.) Flower Extract at pH 6-8.,” Southeast Asian Food Agric. Sci. Technol., pp. 283–291, 2018.
[9] B. Piluharto, A. Sjaifullah, I. Rahmawati, and E. Nurharianto, “Membran Blend Kitosan/Poli Vinil Alkohol (Pva): Pengaruh Komposisi Material Blend, Ph, Dan Konsentrasi Bahan Pengikat Silang,” J. Kim. Ris., vol. 2, no. 2, pp. 77–85, 2017.
[10] S. A. . Saputra, T. Dewi, E. . Ramadhan, N. Ibrahim, and G. Wibisono, “Penutup luka hydrogel berbasis polivinil alkohol (pva), kitosan, pati dengan penambahan asap cair dan vitamin k,” UMS, vol. 002, pp. 1–10, 2020.
[11] N. Wathoni, N. Yuniarsih, A. Cahyanto, and M. Muhctaridi, “applied sciences α -Mangostin Hydrogel Film Based Chitosan – Alginate for Recurrent Aphthous Stomatitis,” Appl. Sci., vol. 9, no. 5235, pp. 1–14, 2019.
[12] D. I. Rudyardjo, “Karakteristik Hidrogel Kitosan-Glutaraldehid Untuk The Effect Of Addition Glycerol As Plasticier To The Characteristics Of Chitosan-Glutaraldehyde Hidrogel For Wound Dressing Application,” J. Ilm. Sains, vol. 14, no. 1, 2014.
[13] R. A. . Wardhani, “Sintesis dan Karakterisasi Bioselulosa–Kitosan Dengan Penambahan Gliserol Sebagai Plasticizer.” Program Studi Fisika FSAINTEK, Surabaya, 2012.
[14] E. . Baran, J. . Mano, and R. . Reis, “Starch-Chitosan Hydrogels Prepared by Reductive Alkylation Cross-linking.,” J. Mater. Sci. Mater. Med., vol. 15, pp. 759–765, 2004.
[15] A. Singh, S. S. Narvi, Dutta, and Pandey, “External Stimuli Response on a Novel Chitosan Hydrogel Crosslinked with Formaldehyde,” Indian Acad. Sci., vol. 29, no. 3, pp. 233–23, 2005.
[16] Erizal, “The Effect Of Hydrogel Dressing Copolymer Poli(Vinylpirrolidone) (Pvp) - K- Carrageenan Prepared By Radiation and Healing Times On The Radius Reductions Burn Injuried Of Wistar White Rat.,” Indones. J. Chem., vol. 8, no. 2, pp. 271–278, 2008.
[17] G. Mutiara PI, Nurdiana, and Y. W. Utami, “Efektifitas Hidrogel Binahong (Anredera cordifolia (Ten.) Steenis) terhadap Penurunan Jumlah Makrofag pada Penyembuhan Luka Fase Proliferasi Tikus Putih (Rattus norvegicus) Galur Wistar Kondisi Hiperglikemia,” Maj. Kesehat. FKUB, vol. 2, no. 1, pp. 29–40, 2015.
[18] S. C. Rohma, E. Umayah, and D. Holidah, “Pengaruh Gel Binahong ( Anredera cordifolia ( Ten .) Steenis )
terhadap Penyembuhan Luka Tikus Diabetes yang Diinduksi Aloksan ( The Effect of Binahong ( Anredera cordifolia ( Ten .) Steenis ) Gel on Wound Healing Process of Diabetic Rats Induced by Allox,” e-Jurnal Pustaka Kesehat., vol. 3, no. 3, pp. 414–418, 2015.
[19] N. Thomas, A. Rusdin, M. Tulsyahra, N. Wathoni, and A. Kuswandi, “Accelerated wound healing ability of Jatropha sap by iota carrageenan-poly (vinyl alcohol) hydrogel film,” J. Technol. Res., vol. 11, no. 4, 2020, doi: 10.4103/japtr.JAPTR.
[20] Z. Ghiasi, F. Esmaeli, M. Aghajani, G. Faramarzi, and A. Amani, “Enhancing analgesic and anti‑inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: An in vivo study,” Int J Pharm, vol. 559, 2019.
[21] Dewantara and Arsana, “Uji Eritema dan Edema Secara In Vivo Pada Natrium Lauril Sulfat 10%,” J. Farm. Udayana, vol. 4, no. 2, 2015.
[22] E. Kemalasari, Karakteristik Mikrobiologi dan Biodegradasi Edible Film Berbasis Pati Ubi Kayu : Tesis. Medan: Program Studi Kimia FMIPA, 2010.
[23] O. . Prameswari and S. B. Widjanarko, “Uji Efek Air Daun Pandan Wangi Terhadap Penurunan Kadar Glukosa Darah dan Histopatologi Tikus Diabetes Melitus,” J. Pangan dan Agroindustri, vol. 2, no. 2, pp. 16–27, 2014.
[24] Zakiatun Azma Amani and R. Mustarichie, “Review Artikel : Aktivitas Antihiperglikemia Beberapa Tanaman Di Indonesia,” Farmaka, vol. 18, no. 1, pp. 53–59, 2021.
[25] Y. P. Utami, A. H. Umar, R. Syahruni, and I. Kadullah, “Standardisasi Simplisia dan Ekstrak Etanol Daun Leilem (Clerodendrum minahassae Teisjm. & Binn.),” J. Pharm. Med. Sci., vol. 2, no. 1, pp. 32–39, 2017.
[26] S. U. Hasnaeni, Wisdawati, “Pengaruh Metode Ekstraksi Terhadap Rendemen Dan Kadar Fenolik Ekstrak Tanaman Kayu Beta-Beta (Lunasia amara Blanco),” J. Farm. Galen. (Galenika J. Pharmacy), vol. 5, no. 2, pp. 166–174, 2019, doi: 10.22487/j24428744.2019.v5.i2.13149.
[27] Departemen Kesehatan RI, Farmakope Herbal Indonesia. Jakarta: Departemen Kesehatan Republik Indonesia, 2008.
[28] S. Susanty and F. Bachmid, “Perbandingan Metode Ekstraksi Maserasi Dan Refluks Terhadap Kadar Fenolik Dari Ekstrak Tongkol Jagung (Zea mays L.),” J. Konversi, vol. 5, no. 2, p. 87, 2016, doi: 10.24853/konversi.5.2.87-92.
[29] Mulchandani, Shah, and T. Mehta, “Synthesis of ChitosanPolyvinyl Alcohol Copolymers for Smart Drug Delivery Application,” Polym. Polym. Compos., vol. 25, pp. 241–246, 2017.
[30] D. A. Samsuri, S. Samsuri, and A. A. S. Kendran, “Kadar Glukosa Darah Tikus Putih (Rattus norvegicus) yang Diberikan Ragi Tape,” Indones. Med. Veterinus, vol. 9, no. 4, pp. 531–539, 2020.
[31] A. Dharmayudha and M. Anthara, “Identifikasi Golongan Senyawa Kimia Estrak Etanol Buah Pare (Momordica charantia) dan Pengaruhnya Terhadap Penurunan Kadar Glukosa Darah Tikus Putih Jantan (Rattus novergicus) yang Diinduksi Aloksan,” Bul.Vet. Udayana, vol. 5, no. 2, pp. 87–95, 2013.
[32] Hestiana, “Faktor-Faktor yang Berhubungan Dengan Kepatuhan Dalam Pengelolaan Diet Pada Pasien Rawat Jalan Diabetes Mellitus Tipe 2 Di Kota Semarang,” Jhe, vol. 2, no. 2, 2017.
[33] Abdullah, Mikrajuddin, N. Virgus, Y, Irmin, and Hairurrijal, “Review: Sintesis Nanomaterial.,” J. Nanosains dan Nanoteknologi, vol. 1, no. 2, pp. 33–57, 2008.
[34] A. A. Nugroho, C. Adianto, and Y. Patria, “Inovasi Wound Healing Gel Dari Nanopartikel Daun Binahong dan Kayu Manis Pada Luka Kronis,” Bimfi, vol. 7, no. 1, pp. 26–42, 2020.
[35] S. Kumar Singh, A. Dhyani Assistant Professor, A. Shailesh Kumar Singh, C Dhyani, and D. Juyal, “Hydrogel: Preparation, Characterizationand Applications,” Journal, vol. 6, no. 6, pp. 25–32, 2017.
[36] I. D. K. Irianto, P. Purwanto, and M. T. Mardan, “Aktivitas Antibakteri Dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) sebagai Alternatif Pengobatan Mastitis Sapi,” Maj. Farm., vol. 16, no. 2, p. 202, 2020.
[37] S. Siregar, “Hubungan Kadar Gula Darah Sewaktu Dengan Proses Penyembuhan Luka Pada Pasien Post Sectio Caesarea Di Rsu Ipi Medan,” J. Ilm. Keperawatan Imelda, vol. 6, no. 1, 2020.
Published
2024-10-31
How to Cite
WICITA, Prisca Safriani et al.
The effectiveness of butterfly pea hydrogel film (Clitoria ternatea) with chitosan and poly-vinyl-alcohol based as diabetic wound healing.
JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 22, n. 2, p. 205-213, oct. 2024.
ISSN 2614-6495.
Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1483>. Date accessed: 21 nov. 2024.
doi: https://doi.org/10.35814/jifi.v22i2.1483.
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