Herbal Medicine Used to Increase the Libido of Male Mice (Mus musculus): Tribulus terrestris and Panax ginseng

  • Aguslina Kirtishanti Departement of Clinical-Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, 60293, Indonesia
  • Devyani Diah Wulansari Departement of Clinical-Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, 60293, Indonesia
  • Dini Kesuma Departement of Chemistry Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, 60293, Indonesia
  • I Gusti Ayu Laksmi Dwi Putri Departement of Clinical-Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, 60293, Indonesia
  • Amirah Nabila Rahmadinar Departement of Clinical-Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, East Java, 60293, Indonesia
DOI: https://doi.org/10.35814/jifi.v21i2.1485

Abstract

Tribulus terrestris and Panax ginseng are two therapeutic plants that might increase libido. The aim of the study was to see the effects of herbal medicine containing Tribulus terrestris and Panax ginseng on increasing male mice libido. This study used mice divided into two sets of 7 and 14 days. Each group was divided into four parts: control (solvent), comparator (Vitan), and test 1 (herbal medicine). Parameters measured were mice sexual behaviour (introduction, climbing, coitus), sperm concentration, sperm motility, and testicular weight. Except for coitus behaviour, there were no significant changes between groups in the 7 days of treatment. There were significant differences in introduction and climbing behaviour between the control group and test 2 after 14 days of treatment, but not in other parameters. There were no significant variations in any parameters of the mice’s libido between 7 and 14 days of treatment with 1x dose of herbal medicine; however, with 2x doses, only introduction behaviour showed a significant difference. Based on the research results, it can be concluded that administering two doses of herbal medicine can increase the frequency of treatment for 14 days.

References

1. Schardein JN, Hotaling JM. The Impact of Testosterone on Erectile Function. Androgens: Clinical Research and Therapeutics . 2022;3(1):113-24.

2. Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, et al. Erectile dysfunction. Natura Reviews Disease Primers. 2016;2:1-20.

3. Mobley DF, Khera M, Baum N. Recent advances in the treatment of erectile dysfunction. Postgrad Med J. 2017;93:679–85.

4. McCullough AR. Four-year review of sildenafil citrate. Reviews in urology. 2002;4(Suppl 3):S26.

5. Indrahadi D, Wardana A, Pierewan AC. The prevalence of diabetes mellitus and relationship with socioeconomic status in the Indonesian population. Jurnal Gizi Klinik Indonesia. 2021;17(3):103-12.

6. Singh R, Ali A, Jeyabalan G, et al. An overview of the current methodologies used for evaluation of aphrodisiac agents. J. Acute Dis. 2013;2:85–91.

7. Gauthaman K, Adaikan PG, Prasad RN V. Aphrodisiac properties of Tribulus Terrestris extract (protodioscin) in normal and castrated rats. Life Sciences. 2002; 71:1385–96.

8. Lee HW, Lee MS, Kim TH, Alraek T, Zaslawski C, Kim JW, Moon DG. Ginseng for erectile dysfunction: a cochrane systematic review. The World Journal of Men’s Health. 2022;40(2):264- 9.

9. Abdel-Wahhab MA, Joubert O, El-Nekeety AA, Yoon W, Kim Y, Rihn B. Aphrodisiac effects of Panax ginseng extract standardized with ginsenoside Rg3 in male rats. Gen Health Med Sci. 2014;1(1):3-8.

10. Liu ZW, Jiang N, Tao X, Wang XP, Liu XM, Xiao SY. Assessment of sexual behavior of male mice. JoVE (Journal of Visualized Experiments). 2020; 157:e60154.

11. Sumarmin R, Huda NK, Yuniarti E. In vivo test of bitter (Andrographis paniculata nees.) extract to ejaculated sperm quality. IOP Conference Series: Earth and Environmental Science 2018;130(1):012041.

12. Singh S, Nair V, Gupta YK. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats. J Pharmacol Pharmacother. 2012; 3: 43.

13. Akram M, Asif HM, Akhtar N, et al. Tribulus terrestris Linn.: A review article. Journal of Medicinal Plants Research. 2011;5:3601–5.

14. Leung KW, Wong AS. Ginseng and male reproductive function. Spermatogenesis. 2013;3(3):e26391.

15. Habeeb IA, Sawad AA, Abbas MF. Study the effect of Panax ginseng on testicular morphology, some sperm properties and testicular histology in male Japanese quail. Biochem Cell Arch. 2020;20:6237–42.

16. Montoto LG, Arregui L, Sanchez NM, Gomendio M, Roldan ERS. Postnatal testicular development in mouse species with different levels of sperm competition. Society for Reproduction and Fertility. 2012;143:333-46.

17. Qureshi A, Naughton DP, Petroczi A. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J. Diet Suppl. 2014;11(1):64-79.

18. Ara A, Vishvkarma R, Mehta P, Rajender S. The profertility and aphrodisiac activities of Tribulus terrestris L.: evidence from meta-analyses. Andrologia. 2023; 2023:1-21.
Published
2023-10-19
How to Cite
KIRTISHANTI, Aguslina et al. Herbal Medicine Used to Increase the Libido of Male Mice (Mus musculus): Tribulus terrestris and Panax ginseng. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 21, n. 2, p. 279-285, oct. 2023. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1485>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.35814/jifi.v21i2.1485.
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Vol 21 No 2 (2023): JIFI
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