Formulation and test of mosquito repellent lotion from the extract of kecombrang (Etlingera elatior (Jack)) and beluntas (Pluchea indica) leaves extract

  • Shelly Taurhesia Masters of Pharmaceutical Science, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Endah Endah Masters of Pharmaceutical Science, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Witono Basuki Masters of Pharmaceutical Science, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Ratna Djamil Department of Natural Product, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
DOI: https://doi.org/10.35814/jifi.v22i1.1521

Abstract

Dengue fever is an infectious disease which is transmitted by Aedes aegypti mosquitoes and commonly occurs in Indonesia. The use of natural ingredients for mosquito repellent is becoming a trend. Kecombrang (Etlingera elatior (Jack)) is known as a medicinal plant which contains alkaloids, saponins, tannins, phenolics, flavonoids, triterpenoids, steroids, and glycosides. Beluntas (Pluchea indica) contains tannins, alkaloids, flavonoids, phenols, saponins and essential oils. This study aims to develop mosquito repellent lotion using combined leaf extracts of E. elatior and P. indica at different ratios (1:1; 1:2; 2:1). The materials used in this study were E. elatior and P. indica leaves, Aedes aegypti mosquitoes, 96% ethanol, stearic  acid, triethanolamine, white oil, methyl paraben, cetyl alcohol, and distilled water. The repellent activity is tested using a standard method of WHO, comparing control group and treatment group, repeating for four times, then          the protection level was calculated. The three formulas of lotion fulfilled both physical and  chemical requirements and had a repellent activity of above 80%. The formulae of F3, a lotion containing both E. elatior and P. indica leaf extracts of 2:1, gave the highest protection of 88.1%.

References

[1] W. H. Wang et al., “Dengue hemorrhagic fever – A systemic literature review of current perspectives on pathogenesis, prevention and control,” J. Microbiol. Immunol. Infect., vol. 53, no. 6, pp. 963–978, 2020, doi: 10.1016/j.jmii.2020.03.007.

[2] A. Kardinan, “POTENSI SELASIH SEBAGAI REPELLENT TERHADAP NYAMUK Aedes aegypti,” J. Penelit. Tanam. Ind., vol. 13, no. 2, p. 39, 2007, doi: 10.21082/jlittri.v13n2.2007.39-42.

[3] K. RI Kesehatan, “Kasus DBD di Indonesia sampai minggu ke 33 tahun 2023.” 2023.

[4] Rashman, L. Taha, and Juhaerah, “Ability of Papaya Leaf Extract ( Carica papaya ) in Controlling Aedes Aegypti Mosquito ( Experimental Study ),” Int. J. Sci. Basic Appl. Res., vol. 24, no. 3, pp. 164–172, 2015.

[5] D. Champakaew et al., “Repellent effect of local indigenous knowledge-based repellent in Nakhon Si Thammarat, Thailand, against Aedes aegypti mosquito,” Heliyon, vol. 9, no. 11, p. e21589, 2023, doi: 10.1016/j.heliyon.2023.e21589.

[6] A. Y. Fitriana, R. Wahyuningrum, and Sudarso, “Daya Repelan Dan Uji Iritasi Formula Lotion Ekstrak Etanol Daun Sirih (Piper Betle Linn) Dengan Variasi Basis Lanolin Terhadap Nyamuk Aedes aegypti,” Pharmacy, vol. 09, no. 02, pp. 1–9, 2012.

[7] M. E. Koraag, H. Anastasia, R. Isnawati, and O. Octaviani, “Efikasi Ekstrak Daun dan Bunga Kecombrang (Etlingera elatior) terhadap Larva Aedes aegypti,” ASPIRATOR - J. Vector-borne Dis. Stud., vol. 8, no. 2, pp. 63–68, 2016, doi: 10.22435/aspirator.v8i2.4615.63-68.

[8] A. Maimulyanti and A. R. Prihadi, “Chemical composition , phytochemical and antioxidant activity from extract of Etlingera elatior flower from Indonesia,” J. Pharmacogn. Phytochem., vol. 3, no. 6, pp. 233–238, 2015.

[9] K. Nisrina Effendi, N. Fauziah, R. Wicaksono, Erminawati, P. Arsil, and R. Naufalin, “Analysis of bioactive components and phytochemical of powders stem and leaves of kecombrang (etlingera elatior),” IOP Conf. Ser. Earth Environ. Sci., vol. 406, no. 1, 2019, doi: 10.1088/1755-1315/406/1/012003.

[10] A. N. Shobah, F. Noviyanto, and N. M. Kurnia, “Kombinasi Ekstrak Daun Kecombrang (Etlingera elatior) dan Daun Beluntas (Pluchea indica) sebagai Biolarvasida,” J. Kesehat. PERINTIS (Perintis’s Heal. Journal), vol. 8, no. 2, pp. 100–109, 2021, doi: 10.33653/jkp.v8i2.675.

[11] E. Susetyarini, P. Wahyono, R. Latifa, and E. Nurrohman, “The Identification of Morphological and Anatomical Structures of Pluchea indica,” J. Phys. Conf. Ser., vol. 1539, no. 1, pp. 0–13, 2020, doi: 10.1088/1742-6596/1539/1/012001.

[12] E. W. C. Chan, Y. K. Ng, S. K. Wong, and H. T. Chan, “Pluchea indica: An updated review of its botany, uses, bioactive compounds and pharmacological properties,” Pharm. Sci. Asia, vol. 49, no. 1, pp. 77–85, 2022, doi: 10.29090/PSA.2022.01.21.113.

[13] D. Sukandar, N. Radiastuti, I. Jayanegara, and A. Hudaya, “Karakterisasi Senyawa Aktif Antibakteri Ekstrak Air Bunga Kecombrang (Etlingera elatior) Sebagai Bahan Pangan Fungsional,” J. Kim. Val., vol. 2, no. 1, 2010, doi: 10.15408/jkv.v2i1.232.

[14] D. Barnard, U. Bernier, R. Xue, and M. Debboun, “Standard Methods for Testing Mosquito Repellents,” Insect Repellents, no. January, pp. 103–110, 2007, doi: 10.1201/9781420006650.ch5.

[15] BPOM, “Peraturan Badan Pengawas Obat Dan Makanan Nomor 10 Tahun 2022 Tentang Pedoman Uji Toksisitas Praklinik Secara In Vivo,” Badan Pengawas Obat dan Makanan Republik Indones., pp. 1–220, 2022.

[16] Syaiful, A. Zaeni, R. Suryani, and J. Hamsidi, “Formulasi Losio Antinyamuk Dengan Zat Aktif Minyak Atsiri Lantana camara Linn.,” J. Farm. dan Ilmu Kefarmasian Indones., vol. 2, no. 1, pp. 2–5, 2015.
Published
2024-04-30
How to Cite
TAURHESIA, Shelly et al. Formulation and test of mosquito repellent lotion from the extract of kecombrang (Etlingera elatior (Jack)) and beluntas (Pluchea indica) leaves extract. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 22, n. 1, p. 54-60, apr. 2024. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1521>. Date accessed: 18 nov. 2024. doi: https://doi.org/10.35814/jifi.v22i1.1521.
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