The association between knowledge and implementation of good compounding practice among pharmacy practitioners at community pharmacies in Central Jakarta

  • Adin Hakim Kurniawan The Diploma of Pharmacy Studies Program, Jakarta II Health polytechnic of the Ministry of Health, Jakarta, Indonesia, 10560, Indonesia http://orcid.org/0000-0001-8422-7672
  • Ulya Safrina The Diploma of Pharmacy Studies Program, Jakarta II Health polytechnic of the Ministry of Health, Jakarta, Indonesia, 10560, Indonesia http://orcid.org/0000-0002-8506-5334
  • Yusmaniar Yusmaniar The Diploma of Pharmacy Studies Program, Jakarta II Health polytechnic of the Ministry of Health, Jakarta, Indonesia, 10560, Indonesia http://orcid.org/0000-0002-5073-5182

Abstract

Drug compounding in community pharmacy is an important process in providing drugs according to patient needs. Poor compounding practices can pose serious health and safety risks. To improve the quality of compounds used in medicinal preparations, Pharmacists need to increase their knowledge and Good Compounding Practice (GCP). This study aimed to analyze the application knowledge of pharmacists regarding GCP of non-sterile preparations in Central Jakarta Regional Pharmacies. This type of research is observational research using cross-sectional descriptive methods. Data collection was carried out using a questionnaire distributed to 82 pharmacy practitioners working in the pharmacy community and using a structured questionnaire to evaluate the level of knowledge and implementation of GCP. The data analysis technique used is chi-square. Most of the Pharmacy Practitioners had good knowledge scores (71.95%). Meanwhile, the level of implementation of GCP has a good implementation value (82.92%). Good knowledge and implementation of Good Compounding Practice is very important to maintain the integrity and safety of drugs produced in compounding practices. This must be implemented in the training and education of pharmaceutical practitioners to help maintain the quality of safe and effective drug compounding practices.

References

[1] S. H. Yuliani, D. C. A. Putri, D. M. Virginia, M. R. Gani, and F. D. O. Riswanto, “Prevalence, Risk, and Challenges of Extemporaneous Preparation for Pediatric Patients in Developing Nations: A Review,” Pharmaceutics, vol. 15, no. 3, p. 840, Mar. 2023, doi: 10.3390/pharmaceutics15030840.

[2] A. N. Zaid, R. Al-Ramahi, Q. Shahed, B. Saleh, and J. Elaraj, “Determinants and frequency of pharmaceutical compounding in pharmacy practice in Palestine,” Int. J. Pharm. Pract., vol. 20, no. 1, pp. 9–14, Feb. 2012, doi: d.

[3] A. Siamidi, Ν. Pippa, and C. Demetzos, “Pharmaceutical compounding: Recent advances, lessons learned and future perspectives,” in Global Drugs and Therapeutics, 2017. doi: 10.15761/GDT.1000115.

[4] M. Dooms and M. Carvalho, “Compounded medication for patients with rare diseases,” Orphanet J. Rare Dis., vol. 13, no. 1, p. 1, Jan. 2018, doi: 10.1186/s13023-017-0741-y.

[5] C. J. Watson, J. D. Whitledge, A. M. Siani, and M. M. Burns, “Pharmaceutical Compounding: a History, Regulatory Overview, and Systematic Review of Compounding Errors,” J. Med. Toxicol. Off. J. Am. Coll. Med. Toxicol., vol. 17, no. 2, pp. 197–217, Apr. 2021, doi: 10.1007/s13181-020-00814-3.

[6] D. A. P. S. Dewi and C. Wiedyaningsih, “evaluası struktur pelayanan praktek peracıkan obat dı puskesmas wılayah kabupaten badung, balı,” Maj. Farm., vol. 8, no. 2, Art. no. 2, May 2017, doi: 10.22146/farmaseutik.v8i2.24070.

[7] M. S. Medina et al., “Center for the Advancement of Pharmacy Education 2013 Educational Outcomes,” Am. J. Pharm. Educ., vol. 77, no. 8, p. 162, Oct. 2013, doi: 10.5688/ajpe778162.

[8] D. Assefa et al., “Investigating the knowledge, perception, and practice of healthcare practitioners toward rational use of compounded medications and its contribution to antimicrobial resistance: a cross-sectional study,” BMC Health Serv. Res., vol. 22, no. 1, p. 243, Feb. 2022, doi: 10.1186/s12913-022-07649-4.

[9] H. Z. Toklu and A. Hussain, “The changing face of pharmacy practice and the need for a new model of pharmacy education,” J. Young Pharm. JYP, vol. 5, no. 2, pp. 38–40, Jun. 2013, doi: 10.1016/j.jyp.2012.09.001.

[10] S. W. Landry, B. Singleton, S. Al-Dahir, A. Nguyen, and D. S. Robinson, “Sterile Compounding Knowledge, Skills, and Confidence Among Graduating Doctor of Pharmacy Students,” Am. J. Pharm. Educ., vol. 85, no. 3, p. 8345, Mar. 2021, doi: 10.5688/ajpe8345.

[11] S. Taylor, Y. Fatima, N. Lakshman, and H. Roberts, “Simulated interprofessional learning activities for rural health care services: perceptions of health care students,” J. Multidiscip. Healthc., vol. 10, pp. 235–241, 2017, doi: 10.2147/JMDH.S140989.

[12] Y. T. Choo, M.-L. Tan, C. H. Goh, and W.-P. Yau, “Compounding training in pharmacy education in Singapore: Perceptions of final year undergraduate pharmacy students and compounding pharmacists,” Asia Pac. Sch., vol. 3, no. 1, pp. 15–26, Jan. 2018, doi: 10.29060/TAPS.2018-3-1/OA1048.

[13] K. A. B. Cauthon, B. J. Bowman, and M. K. Gurney, “Compounding practices and beliefs of Arizona pharmacists,” Int. J. Pharm. Compd., vol. 17, no. 2, pp. 154–161, 2013.

[14] R. Shrewsbury et al., “Assessment and Recommendations of Compounding Education in AACP Member Institutions,” Am. J. Pharm. Educ., vol. 76, no. 7, p. S9, Sep. 2012, doi: 10.5688/ajpe767S9.

[15] F. Cokro, S. T. Arrang, M. A. Chiara, and O. S. Hendra, “Prevalence of pharmacist knowledge on beyond-use date (BUD) of various non-sterile compounding drugs in Indonesia,” Pharm. Pract., vol. 20, no. 1, p. 2630, 2022, doi: 10.18549/PharmPract.2022.1.2630.

[16] K. Hollis, F. Payen, and R. Vaillancourt, “Implementation of Beyond-Use Date Guidelines for Single-Use Vials at a Pediatric Hospital,” Can. J. Hosp. Pharm., vol. 74, no. 1, pp. 70–74, 2021.

[17] B. Nurbaety, C. Rahmawati, B. L. P. Anjani, B. L. Nopitasari, and D. M. Ningrum, “Pharmacy student knowledge level regarding the beyond-use date,” Pharm. Educ., vol. 23, no. 2, Art. no. 2, May 2023, doi: 10.46542/pe.2023.232.6064.

[18] H. S. AlKhatib, S. Jalouqa, N. Maraqa, A. Ratka, E. Elayeh, and S. Al Muhaissen, “Prevalence, determinants, and characteristics of extemporaneous compounding in Jordanian pharmacies,” BMC Health Serv. Res., vol. 19, no. 1, p. 816, Nov. 2019, doi: 10.1186/s12913-019-4684-y.

[19] L. V. Allen, “Basics of compounding: implementing United States pharmacopeia chapter <795> pharmaceutical compounding--nonsterile preparations, part 4,” Int. J. Pharm. Compd., vol. 16, no. 1, pp. 64–68, 2012.

[20] A. D. Wollitz, C. Hong, and F. Blanco, “Compounding sterile products during a personal protective equipment shortage,” Am. J. Health-Syst. Pharm. AJHP Off. J. Am. Soc. Health-Syst. Pharm., vol. 78, no. 14, pp. 1330–1335, Jul. 2021, doi: 10.1093/ajhp/zxab112.

[21] S. Kosari et al., “Evaluation of Pharmaceutical Compounding Training in the Australian Undergraduate Pharmacy Curricula,” Pharm. Basel Switz., vol. 8, no. 1, p. 27, Feb. 2020, doi: 10.3390/pharmacy8010027.

[22] “2022 Revisions to USP General Chapters to 795 and 797.” Accessed: Nov. 07, 2023. [Online]. Available: https://go.usp.org/2022_Revisions_795_797?_gl=1*4av71f*_gcl_au*MTAxODAzMTIxOS4xNjk5MzY3Mjcz*_ga*MTI2Mjk0NzE0Mi4xNjk5MzY3Mjc0*_ga_DTGQ04CR27*MTY5OTM2NzI3My4xLjAuMTY5OTM2NzI3My4wLjAuMA.
Published
2024-10-31
How to Cite
KURNIAWAN, Adin Hakim; SAFRINA, Ulya; YUSMANIAR, Yusmaniar. The association between knowledge and implementation of good compounding practice among pharmacy practitioners at community pharmacies in Central Jakarta. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 22, n. 2, p. 214-223, oct. 2024. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1556>. Date accessed: 23 nov. 2024. doi: https://doi.org/10.35814/jifi.v22i2.1556.