Hand, foot, and mouth disease in children: forecasting of future research direction using bibliometric analysis
Abstract
Since 1997, hand, foot, and mouth disease (HFMD) has become a common health problem in Southeast Asia. Various types of research have been conducted and published to handle HFMD. However, until now, many children, especially in the Asia-Pacific region, including Indonesia, still have HFMD-causing enterovirus (EV) infection. By conducting a bibliometric analysis of the literature published over the last 27 years (1997–2024), the direction of HFMD research in children can be predicted, thus research areas that have the potential and still need to be developed for future better HFMD treatment can be known. The important HFMD research topics predicted to continue to develop were identified through keyword analysis, which was subsequently mapped using a network approach. Based on this study, it can be concluded that HFMD research is predicted to lead to the development of synbiotic supplements, which can reduce HFMD severity, especially in children, by utilizing a genome-wide association study (GWAS) and machine learning.
References
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[17] W. T. Ismaya, R. R. Tjandrawinata, and H. Rachmawati, “Lectins from the edible mushroom Agaricus bisporus and their therapeutic potentials,” Molecules, vol. 25, no. 2368, pp. 1–16, 2020.
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[22] C. Yang, C. Deng, J. Wan, L. Zhu, and Q. Leng, “Neutralizing antibody response in the patients with hand, foot and mouth disease to enterovirus 71 and its clinical implications,” Virology Journal, vol. 8, no. 306, pp. 1–6, 2011.
[23] R. R. Tjandrawinata, L. W. Susanto, and D. Nofiarny, “The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings,” Asian Pacific Journal of Tropical Disease, vol. 7, no. 3, pp. 132–140, 2017.
[24] R. R. Tjandrawinata, A. W. Amalia, H. Tuna, V. N. Said, and S. Tan, “Molecular mechanisms of network pharmacology-based immunomodulation of huangqi (Astragali Radix),” Jurnal Ilmu Kefarmasian Indonesia, vol. 20, no. 2, pp. 184–195, 2022.
[25] J. Li, J. Yang, X. Fan, Z. Sun, Y. Sun, H. Li, et al., “Genetic analysis of the P1 region of human enterovirus 71 strains and expression of the 55 F strain VP1 protein,” Virologica Sinica, vol. 27, no. 1, pp. 10–18, 2012.
[26] X. Liu, N. Mao, W. Yu, Q. Chai, H. Wang, W. Wang, et al., “Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China,” Archives of Virology, vol. 159, no. 9, pp. 2497–2502, 2014.
[27] L. Deng, H. L. Jia, C. W. Liu, K. H. Hu, G. Q. Yin, J. W. Ye, et al., “Analysis of differentially expressed proteins involved in hand, foot and mouth disease and normal sera,” Clinical Microbiology and Infection, vol. 18, no. 6, pp. E188–E196, 2012.
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Published
2024-10-31
How to Cite
TAN, Santi; TJANDRAWINATA, Raymond Rubianto.
Hand, foot, and mouth disease in children: forecasting of future research direction using bibliometric analysis.
JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 22, n. 2, p. 261-273, oct. 2024.
ISSN 2614-6495.
Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1563>. Date accessed: 03 dec. 2024.
doi: https://doi.org/10.35814/jifi.v22i2.1563.
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