Lelutung Tokak (Tabernaemontana macrocarpa Jack.) as Source of Bioactive Substances, Antioxidant and Anticancer

  • DJIHAN RYN PRATIWI INSTITUT PERTANIAN BOGOR
  • MARIA BINTANG INSTITUT PERTANIAN BOGOR
  • PARTOMUAN SIMANJUNTAK UNIVERSITAS PANCASILA

Abstract

This research was aimed to determine biologic activities of n-hexane, ethylacetate, ethanol and water extracts of lelutung tokak (Tabernaemontana macrocarpa Jack.) stem as antioxidant and anticancer. The result of this research showed that four extracts of T. Macrocarpa Jack. stem have antioxidation and anticancer activity. The antioxidant activity test with brine shrimp lethality test (BSLT) showed the LC50 value of n-hexane, ethylacetate, ethanol and water extracts of lelutung tokak stem were 567.89; 119.34; 120.56 and 156.44 ppm respectively; with DPPH method were 653.54; 48.10; 53.322 and 121.02 ppm, respectively. The anticancer test result showed that the IC50 of ethylacetate and ethanol extracts were 6.04 and 7.14 ppm, respectively. The phytochemical analysis result showed that four extracts of stem of T. macrocarpa Jack. preliminary contained alkaloid, flavonoid, saponin and tanin compounds. It was concluded that ethylacetate and ethanol extracts of stem of T. macrocarpa Jack. possess a powerful anticancer and antioxidation activities.

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Published
2014-09-30
How to Cite
PRATIWI, DJIHAN RYN; BINTANG, MARIA; SIMANJUNTAK, PARTOMUAN. Lelutung Tokak (Tabernaemontana macrocarpa Jack.) as Source of Bioactive Substances, Antioxidant and Anticancer. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 12, n. 2, p. 267-272, sep. 2014. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/164>. Date accessed: 31 may 2025.
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Vol 12 No 2 (2014): JIFI
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