Immunomodulatory Effect of Polysaccharide from White Turmeric [Curcuma zedoaria(Christm.) Roscoe)] Rhizome

  • MEUTIA FARADILLA INSTITUT TEKNOLOGI BANDUNG
  • MARIA IMMACULATA IWO INSTITUT TEKNOLOGI BANDUNG

Abstract

Polysaccharide from white turmeric [Curcuma zedoaria (Christm.) Roscoe)] rhizome has been found to have anti-tumor activity against sarcoma 180 cells and able to increase macrophage activity in vitro. Since the modulation of immune system also plays a role in eliminating tumor cell, this study was aimed to determine the immunomodulatory effect of C. zedoaria polysaccharide.Immunomodulatory activity of the polysaccharide fraction was studied in Swiss Webster mice through determination of phagocytic index from reticuloendothelial system, total antibody titers, delayed type hypersensitivity (DTH) reaction and splenocyte proliferation assay. Based on the carbon clearance test, polysaccharide fraction at dose 300 mg/kg bw has higher phagocytic index (1.34) which means it has immunostimulatory activity. At the same dose, polysaccharide fraction enhance humoral immune response shown by primary and secondary antibody titers (1:128 and 1:4096) higher than control. This dose also stimulated delayed type hypersensitivity reactions by 19.41% respectively. In splenocyte proliferation assay, polysaccharide fraction of C. zedoaria was significantly stimulated splenocyte proliferation at contentration 10-6 to 1 mg/mL (p < 0.01). Based on those results, polysaccharide fraction of C. zedoaria at dose 300 mg/kg bw has potency to be developed as immunomodulator.

References

1. Heyne K. Tumbuhan berguna Indonesia. Vol. I. Jakarta: Badan Litbang Kehutanan; 1987. 602-3.
2. Hutapea JR. Inventaris tanaman obat Indonesia (II). Jakarta: Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan RI; 1993. 167.
3. Medical economics company. PDR for herbal medicines. 2nd Ed. New Jersey: Montvale; 2000. 846-7.
4. Guan D, Zhang Z, Yang Y, Xing G, Liu J. Immunomodulatory activity of polysaccharide from the roots of Actinidia kolomikta on macrophages.International Journal of Biology. 2011. 3 (2):3-11.
5. Kim KI, Kim HK, Kim JW, Hong BS, Shin DH, Cho HY, et al. Antitumor, genotoxicity and anticlastogenic activities of polysaccharide from Curcuma zedoaria. Mol Cell. 2000.10:392-8.
6. Kim KI, Shin KS, Jun WJ, Hong BS, Shin DH, Cho HY, et al. Effects of polysaccharides from rhizomes of Curcuma zedoaria on macrophage functions. Biosci Biotechnol Biochem. 2001. 65(11): 2369-77.
7. Deng X, Wu F, Liu Z, Luo M, Li L, Ni Q, et al. Thesplenic toxicity of water soluble multi-walled carbon nanotubes in mice. Carbon. 2009. 47: 1421-28.
8. Rinki S, Mishra RN. Immunomodulatory activity of Triphala megaext. International Journal of Research in Pharmaceutical & Biomedical Sciences. 2011. 2(2): 575-9.9. Dashputre NL, Naikwade. Immunomodulatory activity of abutilon indicum linn on albino mice. International Journal of Pharma Sciences & Research. 2010. 1(3):178-84
Published
2014-09-30
How to Cite
FARADILLA, MEUTIA; IWO, MARIA IMMACULATA. Immunomodulatory Effect of Polysaccharide from White Turmeric [Curcuma zedoaria(Christm.) Roscoe)] Rhizome. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 12, n. 2, p. 273-278, sep. 2014. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/165>. Date accessed: 22 dec. 2024.
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Vol 12 No 2 (2014): JIFI
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