Andrographis paniculata (Burm.F.) in-silico analysis compounds that function as an insulin sensitizer therapy for type 2 diabetes via peroxisome proliferator activated gamma receptors (PPAR y) receptor activator

  • Pristiyantoro Pristiyantoro Doctor of Pharmaceutical Sciences Program, Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
  • Siswandono .Siswandono Department of Pharmaceutical Chemistry ​Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia
  • Esti Mumpuni Faculty of Pharmacy, Universitas Pancasila, Jakarta, 12640, Indonesia
DOI: https://doi.org/10.35814/jifi.v23i1.1651

Abstract

This study examines the following compounds found in Andrographis paniculata: 5-Hydroxy-7,8-dimethoxyflavone, Cinnamic Acid, Ferulic Acid, Caffeic Acid, Apigenin 7,4'-dimethyl ether, 5. 4-Dihidroxy-7,8,2',3'-tetramethoxyflavone, 5-Hydroxy-3,7,8,2' tetramethoxyflavone, and 5-Hydroxy-7,2',6'-trimethoxyflavone all have mild anti-diabetic effects. Analyses are conducted to determine which susceptible individuals have the best activity as Insulin Sensitizers for type 2 diabetes when compared to pioglitazon. The research is conducted using CambridgeSoft's ChemDraw Ultra 22.2.0 3300.2023 (Perkin Elmer) and Chem3D Ultra 22. 2.0 3300. 2023 (Perkin Elmer) software. Docking program for activity prediction using Molegro Virtual Docker 2013.6.0.0 and peroxisome proliferator-activated receptor-gamma (PPAR) code PDB: 5Y2O used. When compared to pioglitazone, 5,4'-Dihidroxy-7,8,2', and 3'-tetramethoxyflavone is predicted to have good anti-diabetic properties.

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Published
2025-04-30
How to Cite
PRISTIYANTORO, Pristiyantoro; .SISWANDONO, Siswandono; MUMPUNI, Esti. Andrographis paniculata (Burm.F.) in-silico analysis compounds that function as an insulin sensitizer therapy for type 2 diabetes via peroxisome proliferator activated gamma receptors (PPAR y) receptor activator. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 23, n. 1, p. 29-37, apr. 2025. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1651>. Date accessed: 04 may 2025. doi: https://doi.org/10.35814/jifi.v23i1.1651.
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Vol 23 No 1 (2025): JIFI In press
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