Analysis for quality of senggugu plant and herbal product (Rotheca Serrata (L.) with metabolomics approach

  • Rahmatul Qodriah Pharmacy Department, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
  • Zuhelmi Aziz Pharmacy Department, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
  • Volin Damayanti Pharmacy Department, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
  • Aura Dyah Alya Pharmacy Department, Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta 12640, Indonesia
DOI: https://doi.org/10.35814/jifi.v22i2.1670

Abstract

Senggugu plant (Rotheca serrata (L.) has many benefits and has the potential as a raw material for herbal medicine, so an identify in the form of an FTIR fingerprint profile is needed. The purpose of this study was to ensure the quality of simplisia and herbal product of senggugu roots and leaves by metabolomics approach. Simplisia and herbal products powder of senggugu leaves and roots were extracted with 70% ethanol solvent using ultrasonic method. The dried extracts of simplisia and herbal products were analyzed by FTIR and TLC-Densitometry. Data obtained from FTIR and TLC-Densitometry analyzed with multivariate data analysis techniques, Principal Component Analysis (PCA) to obtain fingerprint profiles. The PCA results obtained a total Principal Component value of 98,7% and showed that leaf simplisia and herbal products of senggugu leaves can cluster well, while root simplisia and herbal products of senggugu roots were at a distance from the plot. The analysis with OPLS-DA showed the same fungtional groups, which are C=H, O-H, C=C. The results of antioxidant activity testing of 70% ethanol extracts of leaves, roots, and herbal products of senggugu obtained strong antioxidant activity ability with IC50 values of 80,08; 92,12; 80,53; and 94,03 ppm.

References

[1] J. J. Patet, S.R. Acharya, and N.S. Acharya. Cleodendrum serratum (L.) Moon. – A review on traditional uses, phytochemistry and pharmacological activities. Journal Ethnopharmacology. Vol 154, no. 2, pp. 268-285, 2014.

[2] D. Seriawan. Atlas tumbuhan obat Indonesia. Jakarta: Trubus Agriwidya, 1999

[3] S. Qamarani dan R. Aryani. Potensi senyawa flavonid sebagai pengobatan luka. Jurnal Riset Farmasi, vol 3, no. 2, pp. 70.

[4] K. J. Handojo and A. Z. E. Syamaroh. Analisis kualitas produk menggunakan metode statistical quality control pada usaha mikro obat tradisional di Banyuwangi. Jurnal Ilmiah Farmasi, vol 6, no. 1, pp. 48-49, 2023

[5] A. Febrianti, E. Hanani, and L. R. Sjahid. Aktivitas antioksidan serta penetapan kadar fenol dan flavonoid total ekstrak diklorometana terpurifikasi daun senggugu (Rotheca serrata (L.) Steane & Mabb.) skripsi. Jakarta: Fakultas Farmasi dan Sains Universitas Muhammadiyah Prof. Dr. Hamka, 2021

[6] Nasrudin, Wahyono, Mustofa, and R. Asmah. Uji aktivitas antioksidan ekstrak etil asetat kuit akar senggugu (Clerodendrum serratum) asal imogiri, Yogyakarta. Universitas Whid Hasyim: Prosiding Seminar Nasional Peluang Herbal sebagai Alternative Medicine, 2015.

[7] N.W. Sari, M.Y. Fajri, and A. Wilapangga. Analisis fitokimia dan gugus fungsi dari ekstrak goroho merah (Musa
acuminate (L)). İndonesian Journal of Biotechnology and Biodiversity, vol 2, no. 1, pp.30-34, 2018.

[8] D. A. Skoog, F. J. Holler, and N. Yantih. Bahan ajar: Analisis instrumental. Jakarta: Fakultas Farmasi Universitas Pancasila, 2009.

[9] A. Rohman. Statistika dan kemometrika dasar dalam analisis farmasi. Yogyakarta: pustaka pelajar, 2014.

[10] B. Mickiewicz, P. Tam, C. N. Jenne, et. al. Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit. Journal of Critical Care, vol 19, no. 11, pp. 3, 2015.

[11] W. Cahyadi, T. Gozali, and A. Fachrina. Pengaruh konsentrasi gula stevia dan penambahan asam askorbat terhadap karakteristik koktil bawang dayak (Eleutherine palmifolia). Pasundan Food and Technology Journal, vol 5, no.2, pp. 154- 163, 2018.

[12] K. Sayuti and R. Yenrina. Antioksidan alami dan sintetik. Padang: Andalas University Press, 2015.

[13] S. Nurhalisa, I. Ibrahim, and I. A. P. Paerah. Formulasi kapsul daun biji jamblang (Syzigium cumini L.) sebagai antioksidan alami dari desa Pallantikang kabupaten Maros. Jurnal Medika Hutama, vol 2, no. 2, pp.22-27, 2021.
Published
2024-10-31
How to Cite
QODRIAH, Rahmatul et al. Analysis for quality of senggugu plant and herbal product (Rotheca Serrata (L.) with metabolomics approach. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 22, n. 2, p. 331-338, oct. 2024. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/1670>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.35814/jifi.v22i2.1670.
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Vol 22 No 2 (2024): JIFI In-Press
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