Penetrasi Natrium Askorbil Fosfat dalam Sistem Niosom Span 40 secara In Vitro

  • RISE DESNITA UNIVERSITAS TANJUNGPURA
  • VENI LESTIAWATI UNIVERSITAS TANJUNGPURA
  • PRATIWI APRIDAMAYANTI UNIVERSITAS TANJUNGPURA

Abstrak

Sodium ascorbyl phosphate is a hydrophilic compound that is difficult to pass through the stratum corneum. One of the efforts to increase the penetration of the drug through the stratum corneum is to develop in niosome system. This research aims to determine the optimal concentration of span 40 to improve the entrapment efficiency of niosome sodium ascorbyl phosphate formulated in gel and determine the stability and penetration ability of gel formulas. Concentrations of span 40 were varied into three formulas: F1 (100 μmol), F2 (150 μmol) and F3 (200 μmol). Gel formulation was made in two formulas using gel base viscolam MAC 10: G1 (sodium ascorbyl phosphate in niosome system) and G2 (sodium ascorbyl phosphate without niosome system). The stability tests performed for 28 days include organoleptic, pH and determination levels of sodium ascorbyl phosphate in the gel. Penetration test was performed by in-vitro test using shed snake skin membrane. The result showed the optimum entrapment efficiency of F1 formula is 99.13±0.10%. G1 formula is stable for 28 days of storage than G2 formula. The use of span 40 as niosome composer can increase the penetration of sodium ascorbyl phosphate in the gel formulation were 89.04±0.01%.

Diterbitkan
2017-09-04
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DESNITA, RISE; LESTIAWATI, VENI; APRIDAMAYANTI, PRATIWI. Penetrasi Natrium Askorbil Fosfat dalam Sistem Niosom Span 40 secara In Vitro. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 14, n. 2, p. 111-117, sep. 2017. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/19>. Tanggal Akses: 31 mar. 2025
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Vol 14 No 2 (2016): JIFI
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