Gastroprotective Activity of Combination of Neem (Azadirachta indica A. Juss) Bark and Turmeric (Curucuma domestica Linn.) Rhizome Extracts on Rats Induced by Acetosal



Some pre-clinical and clinical studies reported that neem (Azadirachta indica A. Juss) bark and turmeric (Curcuma domestica Linn.) rhizome extracts demonstrated strong gastroprotective activities. In this studies, the effect of combination of neem bark and turmeric rhizome extracts were investigated on acetosal-induced gastric ulcer in rats.The combination is expected to produce synergic effect on the gastric ulcer. The combination of extracts was administered orally in various doses for 7 days prior to the ulcer induction. On the 8th-day rats were given asetosal 400 mg/kg bw to induce gastric ulcer. All rats were sacrificed 8 hours after asetosal induction for the determination of ulcer index, total acidity, mucus thickness and histophatological examination. The combination of neem bark extract (250 mg/kg bw) and turmeric rhizome extract (50 mg/kg bw) was significantly reduced the ulcer index (a = 0.05). This result was substantiated by histophatological examinations. Results of this study showed that combination of neem bark and turmeric rhizome extracts have synergic gastroprotective activities.


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How to Cite
SARI, SANTI PUMA; MUN’IM, ABDUL; KUSUMANINGTYAS, DINI. Gastroprotective Activity of Combination of Neem (Azadirachta indica A. Juss) Bark and Turmeric (Curucuma domestica Linn.) Rhizome Extracts on Rats Induced by Acetosal. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 11, n. 2, p. 97-101, sep. 2013. ISSN 2614-6495. Available at: <>. Date accessed: 22 mar. 2023.