Pengaruh Plasticizer Gliserol dan Sorbitol terhadap Karakteristik Film Penutup Luka Kitosan-Tripolifosfat yang Mengandung Asiatikosida

  • YUNI ANGGRAENI UIN SYARIF HIDAYATULLAH
  • FARIDA SULISTIAWATI UIN SYARIF HIDAYATULLAH
  • DWI NUR ASTRIA UIN SYARIF HIDAYATULLAH

Abstrak

Plasticizers are often added to formula of a film to improve its mechanical properties. Chitosan-tripolyphosphate films dressing containing asiaticoside have been prepared using glycerol and sorbitol as a plasticizer. The purpose of this research was to study the affect of composition and concentration of glycerol and sorbitol as a plasticizer on the characteristics of the films. The films were made in fifteen formulas with variations in composition and concentration of plasticizers. Plasticizers composed of glycerol and sorbitol with ratio 100:0 (formula A), 75:25 (formula B), 50:50 (formula C), 25:75 (formula D) and 0:100 (formula E). The concentrations of plasticizers in formula were 40%, 60% and 80% v/w of chitosan weight. The films were evaluated for physical stability, thickness, water vapor transmission rate, moisture absorption, water retention capacity, folding test, tensile strength and elongation at break. The results showed that the composition and consentration of plasticizer glycerol and sorbitol significantly affect on thickness, tensile strength and elongation at break of the film (p<0.05), and no significantly affect on rate of water vapor transmission and water retention capacity of the film (p>0.05). Formula C with 60% and 80% of plasticizer concentration can be continued for producing chitosan-tripolyphosphate film dressing containing asiaticoside.

Diterbitkan
2017-09-04
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ANGGRAENI, YUNI; SULISTIAWATI, FARIDA; ASTRIA, DWI NUR. Pengaruh Plasticizer Gliserol dan Sorbitol terhadap Karakteristik Film Penutup Luka Kitosan-Tripolifosfat yang Mengandung Asiatikosida. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 14, n. 2, p. 128 - 134, sep. 2017. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/21>. Tanggal Akses: 31 mar. 2025
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Terbitan
Vol 14 No 2 (2016): JIFI
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Articles
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