3,3’-Di(5,7-dibromoindol-3-yl)-indolin-2-one: Synthesis and Cytotoxic Assays against WiDr Colon Cancer Cells

  • KAMILIA MUSTIKASARI UNIVERSITAS LAMBUNGMANGKURAT
  • MARDI SANTOSO INSTITUT TEKNOLOGI SEPULUH NOPEMBER

Abstract

Colon cancer is one of the causes of death in the world of concern, because until now there has not been found specific drug for its treatment. Therefore, the study aimed to synthesize compounds that have the potential as a novel anticancer compound derivative such as 3,3’-di (indol-3-yl) indolin-2-one is required. Synthesis was done by reacting 5,7-dibromoindole and isatin in methanol with an acid catalyst to produce 3,3’-di (5,7-dibromoindol-3-yl)-indolin-2-one compound with a yield of 48%. 3,3 ‘-di (5,7-dibromoindol-3-yl)-indolin-2-one is cytotoxic against colon cancer cell line WiDr with IC50 of 6.64 μM.

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Published
2013-09-30
How to Cite
MUSTIKASARI, KAMILIA; SANTOSO, MARDI. 3,3’-Di(5,7-dibromoindol-3-yl)-indolin-2-one: Synthesis and Cytotoxic Assays against WiDr Colon Cancer Cells. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 11, n. 2, p. 156-159, sep. 2013. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/210>. Date accessed: 27 dec. 2024.
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Vol 11 No 2 (2013): JIFI
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