Optimization of Metochlopramide-Orally Disintegrating Tablet Using Solid Tape Extract and Corn Starch



The preparation of brewed white sticky rice extract or brem from white glutinous rice had been researched by using variation concentration of yeast. The yeasts were bought from traditional market without trade mark. Tape extract obtained by squeezed tape mass using a pressurized equipment, water of tape obtained further filtered using a 60 mesh sieve and the waste is disposed. The variation of yeast influences the pH of liquid tape extract. The optimum concentration of yeast was 1,5%. The research of orally disintegrating tablet (ODT) that using direct compress method was designed by using Simplex Lattice Design (SLD) mixture design programme with two components mixture: brewed white sticky rice extract and corn starch (CS), and metochlopramide as model drug. Brewed white sticky rice extract and CS were formulated become nine designs of formula. Brewed white sticky rice extract was dominant increasing flow and compactability of ODT mass, but decreasing wetting time, disintegrating time and dissolution rate. CS was dominant increasing wetting time, disintegrating time, water absorption ratio and dissolution rate. The optimum ODTs formula was brewed white sticky rice extract (20%) and CS (80%) with flow (8,68±1,72 sec), hardness (2,15±0,14 kg), wetting time (40,00±1,67 sec), disintegrating time (36±10,07 sec), disintegrating time in oral cavity (46,17±2,23 sec) and dissolution rate (0,172 mg/sec).


1. Shyamala B, Narmada GY. Rapid dissolving tablets: A novel dosage form. The Indian Pharmacist. 2002. 13(8):09-12.
2. Bansal AK. Improved excipients by solid-state manipulation. The industrial Pharmacist. 2003.31: 9-12.
3. Alanazi FK. Evaluation of spray and freeze dried excipient bases containing disintegration accelerators for the formulation of metoclopramide orally disintegrating tablets. Saudi Pharmaceutical Journal. 2007.15(2):105-19.
4. Meigia H, Nurhidayat M, Hindun P. 2004. Pembuatan STP padat aneka rasa dan analisis finansialnya (Kajian proporsi air tape (ketan hitam dan ketan putih). Malang: Teknologi Industri Pertanian Universitas Brawijawa Malang; 2000.
5. Soekarto, Soewarno T. Penilaian organoleptik untuk industri pangan dan hasil pertanian. Bogor: Pusbangtepa IPB-press; 1981.
6. Ditjen POM. Farmakope Indonesia, Edisi Ketiga. Jakarta: Departemen Kesehatan Republik Indonesia; 1979.
7. Manivannan R. Orally disintegrating tablets: Future compaction. International Journal of Research and Development-on line. 2009:1-10.
8. Bhowmik D, Chiranjib B, Krishnakanth, Pankaj, Margret R. Fast dissolving tablet: An overview. Journal of Chemical and Pahrmaceutical Research. 2009.1(1): 1-5.
9. Lieberman. Pharmaceutical dosage form, Tablets. Vol. 1. 2nd Ed. Marcel Dekker Inc; 1998. 245-348.
10. Siregar CSP. Teknologi farmasi sediaan tablet: Dasar-dasar praktis Ed. I. Jakarta: EGC; 2010. 161, 575-7.
11. Kundu S, Sahoo PK. Recent trends in the developments of orally disintegrating tablet technology. Pharma Times. 2008.40(4):11-21.
12. Popescu C, Zhou L, Joshi A. 2010. Selection of non-synthetic disintegrants for pharmaceutical and nutraceutical orally disintegrating tablets. p.1-6. [6 tayangan]. URK: http://www.tabletcapsules.com. diakses tanggal 27 Juli 2012.
13. Stat Ease. 2011. Design expert trial Versi downloaded program www.statease.com. Diakses tanggal 18 Mei 2011.
14. Hirani JJ, Dhaval AR, Kantilal RV. Orally disintegrating tablets: A review. Tropical Journal of Pharmaceutical Research. 2009.8(2): 161-172.
How to Cite
SAMRAN, SAMRAN et al. Optimization of Metochlopramide-Orally Disintegrating Tablet Using Solid Tape Extract and Corn Starch. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 11, n. 1, p. 21-27, apr. 2013. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/227>. Date accessed: 29 may 2023.