The Effect of Rambutan Seed (Nephelium lappaceum L.) Infusion on Blood Glucose and Pancreas Histology of Mice Induced with Alloxan

  • LESTARI RAHAYU UNIVERSITAS PANCASILA
  • LATIF ZAKIR UNIVERSITAS PANCASILA
  • SESILIA ANDRIANI KEBAN UNIVERSITAS PANCASILA

Abstract

Rambutan (Nephelium lappaceum L.) is a plant which can be used to treat various diseases, including diabetes mellitus. This research was conducted to investigate the effect of rambutan seed infusion on the mice blood glucose levels and body weight. In this research, 30 mice (Mus musculus) were divided into 6 groups, each group consists of 5 mice. The 6 groups consists of a normal control group (distilled water), negative control group (alloxan tetrahydrate 250 mg/kg bw + distilled water), three experimental groups (induced with alloxan 250 mg/kg bw) were given rambutan seed infusion of 1.56 gram/kg bw, 2.34 gram/kg bw and 3.12 gram/kg bw and a positive control group (alloxan tetrahydrate 250 mg/kg bw + treated with glibenclamide 0.65 mg/kg bw). After given treatment for 16 days, it was observed that high dose of rambutan seed infusion has significant effects in reducing the blood glucose and body weight of mice. Histology of the pancreas were checked and the ammount of live pancreatic beta cells found in high dose of rambutan seed infusion were almost the same as the positive control group. It can be concluded that the effect of high dose of rambutan seed infusion (3.12 gram/kg bw) was not significantly different from glibenclamide (0,65 mg/kg bw).

References

1. Sunarsih ES, Djatmika, Utomo RS. Pengaruh pemberian infusa umbi gadung (Dioscorea hispida Dennst.) terhadap penurunan kadar glukosa darah tikus putih jantan diabetes yang diinduksi aloksan. Majalah Farmasi Indonesia. 2007.18(1): 30.
2. Kandungan dan manfaat buah rambutan. Diambil dari http://www.malukunews.com/?p=6915. Diakses 10 November 2011, 17:21 WIB.
3. Zulhipri, Kartika IR, Sumaji A. Uji fitokimia dan aktivitas antidiabetes ekstrak biji rambutan (Nephelium Lappaceum L.) dengan berbagai pelarut. Ebers Papyrus. 2007.13(3): 89-91.
4. Kelompok Kerja Ilmiah. Penapisan farmakologi, pengujian fitokimia, dan pengujian klinik. Jakarta: Yayasan Pengembangan Obat Bahan Alam. Phyto Medica; 1993.16-7.
5. Arifandi R. Pengaruh pemberian minyak buah merah (Pandanus conoideus Lam.) terhadap kadar glukosa darah dan gambaran sel β pankreas mencit yang diinduksi dengan aloksan [skripsi]. Jakarta: Fakutas Farmasi Universitas Pancasila; 2006. 21.
6. Usman K. Pengantar statistik. Jakarta: Bumi Aksara;1996. 149-157.
7. Ganong F. Buku ajar fisiologi kedokteran. Edisi 17. Diterjemahkan oleh: M. Djauhardi Widjajakusuma. Jakarta: Penerbit Buku kedokteran EGC; 2003. 332.
8. Deivy AP. Potensi rebusan daun sirih merah (Piperc roatium) terhadap perbaikan sel pankreas tikus putih hiperglikemia [skripsi] Bogor. Fakultas Matematika dan Ilmu Pengetahuan Alam Institut Pertanian Bogor: 2006.1-3.
9. Guyton CA. Fisiologi manusia dan mekanisme penyakit. Edisi II. Alih Bahasa: Petrus Andrianto. Jakarta: EGC; 1987. 707.
10. Mitruka. Clinical biochemical and hematological refference values in normal experimental animals and normal human, 2nd Ed. New York: Year Book Medical Publisher; 1981. 158.
Published
2013-04-30
How to Cite
RAHAYU, LESTARI; ZAKIR, LATIF; KEBAN, SESILIA ANDRIANI. The Effect of Rambutan Seed (Nephelium lappaceum L.) Infusion on Blood Glucose and Pancreas Histology of Mice Induced with Alloxan. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 11, n. 1, p. 28-35, apr. 2013. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/228>. Date accessed: 19 dec. 2024.
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Vol 11 No 1 (2013): JIFI
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