Antioxidant Activity of Prenylated Flavonoid Compound from Dichloromethane Extract of Artocarpus communis Leaves

PUSPA D.N. LOTULUNG; SOFA FAJRIAH; EUIS FILAILA

PUSPA D.N. LOTULUNG LEMBAGA ILMU PENGETAHUAN INDONESIA
SOFA FAJRIAH LEMBAGA ILMU PENGETAHUAN INDONESIA
EUIS FILAILA LEMBAGA ILMU PENGETAHUAN INDONESIA

Abstract

This research investigated the antioxidant activity of prenylated flavonoid compound from the ichloromethane extract of Artocarpus communis leaves on 1,1-diphenyl-2-picryl hydrazyl free radicals scavenging assay. The dichoromethane extract of Artocarpus communis leaves was fractionated by column chromatography techniques on silica gel, and each fraction was assayed for its activity. The active compound, 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl] 1-propanone, showed moderate antioxidant activity with IC₅₀ 54.6 μg mL^-1.

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