The Optimization Ratio of Tartaric Acid-Sodium Bicarbonate on the Green Tea Extract Effervescent Granule by Dry Granulation Method

  • AGATHA BUDI SUSIANA LESTARI UNIVERSITAS SANATA DHARMA
  • BIRGITA NATALIA DESIHAPSARI UNIVERSITAS SANATA DHARMA

Abstract

The aims of this research are to determine the effects of tartaric acid, sodium bicarbonate and their interaction on the physical properties of effervescent granule made by dry granulation and also to determine the optimum composition area of tartaric acid and sodium bicarbonate that produce qualified effervescent granule. The experimental study employed factorial design with two factors, i.e. tartaric acid and sodium bicarbonate, and two levels, i.e. high level and low level. The formulas were optimized on their physical properties, i.e. the granules flow rate, moisture content, disintegration time and pH of the solution. The data were statistically analyzed using Yate’s treatment with 95% level of confidence. The results show that tartaric acid was dominant in determining the disintegration time of the effervescent granules, while sodium bicarbonate was dominant in determining the moisture content of the effervescent granules. Interaction between tartaric acid and sodium bicarbonate significantly determined the flow rate of the effervescent granules and the pH of the solution. The optimum composition area of tartaric acid and sodium bicarbonate was not produced because there was one physical property of the effervescent granule that was not fulfilled, i.e. the granules moisture content.

References

1. Zhou Q, Chiang C, Portocarrero C, Zhu Y, Hill S, Heppert K, Jayaratna. H. Investigating the Stability of EGCG in Aqueous Media. Current Separation. 2003. 83-5.

2. Hartoyo A. Teh dan Khasiatnya Bagi Kesehatan. Sebuah Tinjauan Ilmiah. Yogyakarta: Penerbit Kanisius; 2003. 15, 16, 30, 36.

3. Sahelian R. Green-Tea-Extract supplement tablets, EGCG epigallocatechin gallate, Advance Physician Formulas. 2005. http://www.physicianformulas.com/ store/scripts/prodView.asp?idproduct=67, diakses tanggal 12 Januari 2009.

4. Departemen Kesehatan Republik Indonesia. Farmakope Indonesia edisi IV. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan; 1995. 601.

5. Bolton, S. Pharmaceutical Statistic Practical and Clinical Application. 3rd ed. Marcel Dekker Inc, New York; 1990. 326-53, 591-601.

6. Fausett H, Gayser C, Dash AK. Evaluation Of Quick Disintegrating Calcium Carbonate Tablets. 2000. http:// www.aapspharmscitech.org/articles/pt0103/pt010320 / pt010320.pdf diakses tanggal 22 Oktober 2008.

7. Linberg N, Hansson H. Effervescent Pharmaceutical in Encyclopedia of Pharmaceutical Technology. 3rd edition. Informa Healthcare USA Inc.; 2007. 1454-65.

8. Kellar S, Poshnii F, Hei L, Penzotti S, Bedu-adoo F, Payne K. Preformulation Development Studies To Evaluate the Properties of Epigallocatechin gallate (EGCG), Cardinal Health Pharmaceutical Development. 2005. http://www. aapspharmsci.org/abstracts/Am_2003/AAPS2003- 002679.PDF, diakses tanggal 5 Oktober 2008.

9. Zhu QY, Zhang A, Tsang D, Huang Y, Chen Z. Stability of Green Tea Catechins, Department of Biochemistry and Department of Physiology, The Chinese University of Hong Kong, J Agric Food Chem. 1997. 45(12): 4624−8.
Published
2011-09-30
How to Cite
LESTARI, AGATHA BUDI SUSIANA; DESIHAPSARI, BIRGITA NATALIA. The Optimization Ratio of Tartaric Acid-Sodium Bicarbonate on the Green Tea Extract Effervescent Granule by Dry Granulation Method. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 9, n. 2, p. 136-142, sep. 2011. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/302>. Date accessed: 05 nov. 2024.
Citation Formats
Issue
Vol 9 No 2 (2011): JIFI
Section
Articles
License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.