Design, Synthesis and Citotoxicity Assay of UK-3A analogue: Hydroxypicolinil Dioctyl Glutamic Ester

  • YULIA ANITA LEMBAGA ILMU PENGETAHUAN INDONESIA
  • MUHAMMAD HANAFI LEMBAGA ILMU PENGETAHUAN INDONESIA

Abstract

Antibiotic UK 3A had been isolated as a minor component from the mycelium of Streptomyces sp. 517-0. It was elucidated as a nine-member dilactone ring derivative. To produce an analog of UK-3A, i.e. hydroxypicolinil dioctyl glutamic ester, was synthesized from L glutamic acid and octanol, and the product was then reacted with 3-hydroxypicolinic acid and dioctyl glutamic ester. The tinal product was identified by 1H and 13C FT NMR, FT-IR spectrophotometry, and LC-MS. The it was tested for cytotoxic activity against P388 Murine Leukemia cells. The results showed that the 3-hydroxypicolinyl dioctyl glutamic ester has higher inhibition activity against P388 leukemia cells with IC50 value of 9.80 µg/mL than the activity of UK 3A with IC50 value of 38.4 µg/mL.

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Published
2011-04-30
How to Cite
ANITA, YULIA; HANAFI, MUHAMMAD. Design, Synthesis and Citotoxicity Assay of UK-3A analogue: Hydroxypicolinil Dioctyl Glutamic Ester. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 9, n. 1, p. 27-30, apr. 2011. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/318>. Date accessed: 25 feb. 2024.
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Articles