A Structure-Activity Study of Antioxidant Compounds from the Stem Bark of Kandis Gaj ah (Garcinia griffithii T. Anders)



Four xanthones and two benzophenones from the stem bark of kandis gajah (Garcinia griffithii) by extraction and chromatographic methods have been isolated. The six compounds were determined as: 1,7-dihydroxyxanthone (1), 1,6,7-trihydroxyxanthone (2), 1,6-dihydroxy-3-methoxy-4,7-di-(3-methylbut-2-enyl)xanthone (3), 1,5-dihydroxy-3,6-di-methoxy-2,7-di-(-3-methylbut-2-enyl)xanthone (4), guttipherone I (5), and isoxanthochymol (6). All of the isolated compounds were submitted to antioxidant activity assay using three methods: (i) free radical scavenging method, (ii) xanthine-xanthine oxidase (XO) method, and (iii) nitroblue tetrazolium xanthine oxidase (NBT/ XO). Guttipherone I (5) and isoxanthochymol (6) have strong antioxidant activity (IC50 ≤10.2 µg/mL), 1,6,7-trihydroxyxanthone (2) and 1,6-dihydroxy-3-methoxy-4,7-di-(3-methylbut-2-enyl)xanthone (3) as active compounds (IC50 ≤ 100 µg/mL), while 1,7-dihydroxyxanthone (1) and 1,5-dihydroxy-3,6-dimethoxy-2,7-di-(3-methylbut-2-enyl)xanthone (4) were inactive (IC50 > 100 µg/mL). Base on the data, antioxidant activity of isolated compounds was inhuenced by dihydroxyl groups at ortho position, number of hydroxyl group, and hydroxyl group at para position to C carbonyl at heterocyclic.


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How to Cite
ELFITA, ELFITA et al. A Structure-Activity Study of Antioxidant Compounds from the Stem Bark of Kandis Gaj ah (Garcinia griffithii T. Anders). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 9, n. 1, p. 35-39, apr. 2011. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/323>. Date accessed: 25 feb. 2024.