Optimization of Hydroxy Octadecadienoic Acid (HODE) Production by Culvularia lunata BioMCC FE-00283 Using Response Surface Methodology

  • ERWAHYUNI ENDANG PRABANDARI INSTITUT PERTANIAN BOGOR
  • TUN TEDJA IRAWADI INSTITUT PERTANIAN BOGOR
  • WAHONO SUMARYONO BADAN PENGKAJIAN DAN PENERAPAN TEKNOLOGI
  • KHASWAR SYAMSU INSTITUT PERTANIAN BOGOR

Abstract

Hydroxyl octadecadienoic acid (HODE) is an oxidized aliphatic fatty acid from the oxylipins group, which shows bioactivity and can be produced by Curvularia lunata BioMCC FE-00283 by submerged fermentation. Glucose, monosodium glutamate, and corn oil were media components that showed significant effect toward HODE production by C. lunata BioMCC FE-00283. Composition optimization of these three medium components was carried out by Response surface methodology (RSM). A full factorial central composite design (CCD) was used to explain the interaction effect between media components. Maximum HODE production as predicted by the quadratic model have chromatogram area of 4540000, which was verified experimentally to be 1091338 ± 152489. Eventhough experimental veriiication showed lower result compared to the model prediction, however it was higher compared to the HODE production using basal media with unoptimized composition of carbon, nitrogen, and inducer which only have chromatogram area of 295045 ± 71200. The verification also showed that optimization increased HODE production by 3.7 fold compared to that produced by the unoptimized media.

References

1. Cantrell CL, Knian TM, Case BP, Duke SO, Mena BE, Wedge DE. Isolation and Identification of Antifungal Fatty Acids from the Basidiomycete Gomphus floccosus. J Agric Food Chem. 2008. 56:5062-8.

2. Colquhoun A, Miyake JA, Benadiba M. Fatty acid, eicosanoids and cancer. Nutrit Ther Metabol. 2009. 27(3):105-12.

3. Mundt S, Kreitlow S, Jansen R. Fatty acid with antibacterial activity from cyanobacterium Oscillatoria redekei HUB 051. JAppl Pshycol. 2003. 14:263-7.

4. Wadman MW, van Zadelhoff G, Hamberg M, Visser Y, Veldink GA, Vliegenthart JFG. Conversion of linoleic acid into novel oxylipins by the mushroom Agaricus bisporus. Lipids. 2005. 40(11):1163-70.

5. Wadman MW, de Vries RP, Kalkhove SIC, Veldink GA, Vligentharat J FG. Charaterization of oxylipins and dioxygenase genes in the asexual fungus Aspergillus niger. BMC Microbiol. 2009. 9:59 [serial online]. diambil dari http://www.biomedcentral.com. diakses 20 Mei, 2010.

6. Omar MN, Moynihan H, Hamilton R. Scaling-up production of 13 S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique. Bull Korean Chem Soc. 2003. 24:397-9.

7. Rombi M, Bordighera. Method for obtaining oil that is rich in hydoxyoctadecadienoic fatty acids (HODE) or the esters thereof from a mixture containing linoleic acid or esters thereof. US Patent. February 19th, 2002. 6, 348, 609.

8. Mandenius CF, Brundin A. Bioprocess optimization using design of experiment methodology. Biotechnol Prog. 2008. 24:1191-203.

9. Pansuriya RC, Singhal RS. Response surface methodology for optimization of lovastatin by solid state fermentation. Brazilian J Microbiol. 2010. 41:164-72.

10. Zhang X, Zhou J, Fu W, Li Z, Zhong J, Yang J, et al. Response surface methodology used for statistical optimization of jiean peptide production by Bacillus subtilis. Electronic J Biotechnol. 2010. 13(4). [serial online]. diakses tanggal 24 November, 2010.

11. Gao H, Liu M, Liu J, Dai H, Zhou X, Liu X, 61 et al. Medium optimization for the production of avermectin B 1 a by Streptomyces avermitilis 1412A using response surface methodology. Bioresource Technology. 2009. 100:4012-16.

12. Jiang L. Optimization of fermentation condition for pullulan production by Aureobasz'dium pullulan using response surface methodology. Carbohidrat Poly. 2010. 79:414-7.

13. Nelofer R, Syed Q, Nadeem M. Statistical optimization of process variables for L-lysine production by Corynebacterium glutamicum. Turk J Biochem. 2008. 33(2):50-7.

14. Yan L, Le-he M. Optimization of fermentation conditions for P450 BM-3 monooxygenase production by hybrid design methodology. J Zhejiang Univ Sci B. 2006. 8(1):27-32.

15. Bezerraa MA, Santelli RE, Oliveiraa EP, Villar LS, Escaleira LA. Response surface methodology (RSM) as a tool for optimization in analytical chemistry. Talanta. 2008. 76:965-77.

16. Coetzer RLJ, Haines RLJ, Fatti LP. Central composite designs for estimating the optimum conditions for a second-order model. J Statist Plann Inference. 2010. [online]. diambil dari doi: 10.1016/j.jspi.2010.11.026. diakses tanggal 19 Januari, 2011.

17. Tomita F. Endophytes in Southeast Asia and Japan: their taxonomic and potential applications. Fungal Diversity. 2003. 14:187-204.

18. Watanabe, Pictorial Atlas of Soil and Seed Fungi 2 Morphologies of Cultured Fungi and key to Species. 2nd edition. Boca Raton. CRC Press; 2002. 237.

19. Adinarayana K, Ellaiah P . Response surface optimization of the critical medium components for the production of alkaline protease by a newly isolated Bacillus Sp. J Pharm Pharmaceut Sci. 2002. 5(3):281-7.

20. Prabandari EE, Irawadi TT, Sumaryono W, Syamsu K. Selection of Carbon and Nitrogen Source for Hydroxy Octadecadienoic Acid Production using Endophytic Fungi Curvularia lunata BioMCC FE00283. Microbiol. [dalam publikasi]

21. Jenni S, Leibundgut M, Maier T, Ban N. Architecture of fungal fatty acid synthase at 5 A Resolution. Science. 2006. 311:1263-7.

22. Van Maris AJA, Groothuizen MK, Geertman JM, Winkler AA, van Dij ken JP, Vermeulen A, Piper MDW, et al. Directed Evolution of Pyruvate decarboxylase negative Saccharomyces cerevisiae, Yielding a C-Independent, Glucose-Tolerant, and Pyruvate~ Hyperproducing Yeast. Apll. Environ. Microbiol. 2004. 70(1):159-66

23. Arjol M, Galia MB, Bermudo E. Identification of oxylipins antifungal activity by LC-MS/MS from the supernatant of Pseudomonas 42A2. Chem Phys Lip. 2010.163:341-6

24. Heo SH, Hou CT, Kim BS. Production of oxygenated fatty acids from vegetable oils by Flavobacterz'um sp strain DSS. New Biotechnol. 2009. 26 (1/2): 105-8.

25. Prabandari EE. Optimalisasi media kultivasi Aspergillus terreus untuk produksi lovastatin dengan metode central composite design.[tesis]. Bogor: lnstitut Pertanian Bogor; 2003. 48-9.
Published
2011-04-30
How to Cite
PRABANDARI, ERWAHYUNI ENDANG et al. Optimization of Hydroxy Octadecadienoic Acid (HODE) Production by Culvularia lunata BioMCC FE-00283 Using Response Surface Methodology. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 9, n. 1, p. 46-52, apr. 2011. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/325>. Date accessed: 26 apr. 2024.
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